Dose-dependent effect of 2-deoxy-D-glucose on glycoprotein mannosylation in cancer cells

IUBMB Life ◽  
2015 ◽  
Vol 67 (3) ◽  
pp. 218-226 ◽  
Author(s):  
Aysel Ahadova ◽  
Johannes Gebert ◽  
Magnus von Knebel Doeberitz ◽  
Juergen Kopitz ◽  
Matthias Kloor
Keyword(s):  
Cancer Cells ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Biphasic Dose-Dependent Effect of Lithium Chloride on Survival of Human Hormone-Dependent Breast Cancer Cells (MCF-7)

2012 ◽  
Vol 150 (1-3) ◽  
pp. 477-486 ◽  
Author(s):  
Muralidharan Suganthi ◽  
Gopalakrishnan Sangeetha ◽  
Govindaraj Gayathri ◽  
Bhaskaran Ravi Sankar
Keyword(s):  
Breast Cancer ◽  
Cancer Cells ◽  
Lithium Chloride ◽  
Breast Cancer Cells ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Mcf 7

Dose-dependent effect of Resveratrol on bladder cancer cells: Chemoprevention and oxidative stress

Maturitas ◽  
2012 ◽  
Vol 72 (1) ◽  
pp. 72-78 ◽  
Author(s):  
Bianca Stocco ◽  
Karina Toledo ◽  
Mirian Salvador ◽  
Michele Paulo ◽  
Natália Koyama ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Bladder Cancer ◽  
Cancer Cells ◽  
Dependent Effect ◽  
Bladder Cancer Cells ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
And Oxidative Stress

scholarly journals Silver‐doped sol‐gel borate glasses: Dose‐dependent effect on Pseudomonas aeruginosa biofilms and keratinocyte function

2021 ◽  
Author(s):  
Shiva Naseri ◽  
Gabriele Griffanti ◽  
William C. Lepry ◽  
Vimal B. Maisuria ◽  
Nathalie Tufenkji ◽  
...  
Keyword(s):  
Pseudomonas Aeruginosa ◽  
Sol Gel ◽  
Borate Glasses ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Dose-Dependent Effect of Statins on the Incidence of Acute Kidney Injury After Cardiac Surgery

2011 ◽  
Vol 91 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Salima Mithani ◽  
Michael Kuskowski ◽  
Yelena Slinin ◽  
Areef Ishani ◽  
Edward McFalls ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Cardiac Surgery ◽  
Kidney Injury ◽  
Dependent Effect ◽  
Dose Dependent ◽  
Dose Dependent Effect

Ligand-Regulated Expression of TNF Receptors 1 and 2 Determines Receptor-Mediated Functional Responses

2021 ◽  
pp. 1-12
Author(s):  
Alina Alshevskaya ◽  
Olga Koneva ◽  
Irina Belomestnova ◽  
Julia Lopatnikova ◽  
Irina Evsegneeva ◽  
...  
Keyword(s):  
Biological Effects ◽  
High Expression ◽  
Functional Responses ◽  
Double Positive ◽  
Dependent Effect ◽  
Similar Expression Profile ◽  
Proliferation Response ◽  
Dose Dependent ◽  
Dose Dependent Effect ◽  
Mcf 7

<b><i>Introduction:</i></b> Modulating specific biological effects through the changes in cytokine receptors’ expression level remains poorly understood. This study aimed to investigate the influence of the dose-dependent effect of TNF on the balance between proapoptotic and proliferation response depending on the parameters of TNFR1/2 expression density. <b><i>Methods:</i></b> Tumor cell lines (HEp-2, K-562, MCF-7, ZR-75/1, MOLT-4, IM-9, and Raji) were characterized for TNFR1/2 co-expression using flow cytometry and were studied to reveal the dose-dependent effect of rhTNF on cell cycle and apoptosis parameters. The associations among the studied parameters were estimated by correlation and regression analysis. <b><i>Results:</i></b> It was found for ZR-75/1 cells (the cell line characterized by high expression of both types) that a dose-dependent increase in expression of both types of TNF-α receptors on cells reduces the proliferative activity of cells. For MOLT-4 cells (which are characterized by lower expression), an increase in proliferative response of cells was positively associated with the percentage of both TNFR1<sup>+</sup> and TNFR2<sup>+</sup> cells. However, opposite effects on the cells were shown for the K-562 and MCF-7 lines having a similar expression profile. A similarity (a large percentage of double-positive cells) was revealed for the lines having similar effects (K-562 and ZR-75/1). <b><i>Conclusions:</i></b> High expression of TNF receptor type 1 is not always associated with predominant activation of proapoptotic pathways. However, in the case of simultaneous high expression of both types of receptors, the proportion of double-positive cells is crucial for the activation of either the proapoptotic or proliferation pathways.

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