Preconditioning with hyperbaric oxygen induces tolerance against oxidative injury via increased expression of heme oxygenase-1 in primary cultured spinal cord neurons

Life Sciences ◽  
2007 ◽  
Vol 80 (12) ◽  
pp. 1087-1093 ◽  
Author(s):  
Qingbo Li ◽  
Jinsheng Li ◽  
Lifan Zhang ◽  
Bairen Wang ◽  
Lize Xiong
Keyword(s):  
Spinal Cord ◽  
Hyperbaric Oxygen ◽  
Heme Oxygenase ◽  
Oxidative Injury ◽  
Heme Oxygenase 1 ◽  
Spinal Cord Neurons

Heme oxygenase-1 protects spinal cord neurons from hydrogen peroxide-induced apoptosis via suppression of Cdc42/MLK3/MKK7/JNK3 signaling

APOPTOSIS ◽  
2016 ◽  
Vol 22 (3) ◽  
pp. 449-462 ◽  
Author(s):  
Siyuan Wang ◽  
Tao Zhang ◽  
Zhen Yang ◽  
Jianhua Lin ◽  
Bin Cai ◽  
...  
Keyword(s):  
Hydrogen Peroxide ◽  
Spinal Cord ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Spinal Cord Neurons ◽  
Induced Apoptosis

scholarly journals Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury

2021 ◽  
Vol 22 (3) ◽  
pp. 1382
Author(s):  
Jelena Nesovic Ostojic ◽  
Milan Ivanov ◽  
Nevena Mihailovic-Stanojevic ◽  
Danijela Karanovic ◽  
Sanjin Kovacevic ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Protein Expression ◽  
Hyperbaric Oxygen ◽  
Heme Oxygenase ◽  
Spontaneously Hypertensive Rats ◽  
Wistar Rats ◽  
Kidney Injury ◽  
Heme Oxygenase 1 ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Renal ischemia and reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Pathogenesis of postischemic AKI involves hemodynamic changes, oxidative stress, inflammation process, calcium ion overloading, apoptosis and necrosis. Up to date, therapeutic approaches to treat AKI are extremely limited. Thus, the aim of this study was to evaluate the effects of hyperbaric oxygen (HBO) preconditioning on citoprotective enzyme, heme oxygenase-1 (HO-1), pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins expression, in postischemic AKI induced in normotensive Wistar and spontaneously hypertensive rats (SHR). The animals were randomly divided into six experimental groups: SHAM-operated Wistar rats (W-SHAM), Wistar rats with induced postischemic AKI (W-AKI) and Wistar group with HBO preconditioning before AKI induction (W-AKI + HBO). On the other hand, SHR rats were also divided into same three groups: SHR-SHAM, SHR-AKI and SHR-AKI + HBO. We demonstrated that HBO preconditioning upregulated HO-1 and anti-apoptotic Bcl-2 protein expression, in both Wistar and SH rats. In addition, HBO preconditioning improved glomerular filtration rate, supporting by significant increase in creatinine, urea and phosphate clearances in both rat strains. Considering our results, we can also say that even in hypertensive conditions, we can expect protective effects of HBO preconditioning in experimental model of AKI.

Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control

2018 ◽  
Vol 295 ◽  
pp. 357-368 ◽  
Author(s):  
Roxana Mayra Gorojod ◽  
Agustina Alaimo ◽  
Soledad Porte Alcon ◽  
Jimena Hebe Martinez ◽  
María Eugenia Cortina ◽  
...  
Keyword(s):  
Quality Control ◽  
Heme Oxygenase ◽  
Oxidative Injury ◽  
Heme Oxygenase 1 ◽  
Mitochondrial Quality Control

scholarly journals Effect of canine mesenchymal stromal cells overexpressing heme oxygenase-1 in spinal cord injury

2017 ◽  
Vol 18 (3) ◽  
pp. 377 ◽  
Author(s):  
Seung Hoon Lee ◽  
Yongsun Kim ◽  
Daeun Rhew ◽  
Ahyoung Kim ◽  
Kwang Rae Jo ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heme Oxygenase ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Heme Oxygenase 1 ◽  
Cord Injury

Heme Oxygenase–1 Expression after Spinal Cord Injury: The Induction in Activated Neutrophils

2002 ◽  
Vol 19 (4) ◽  
pp. 479-490 ◽  
Author(s):  
Yi Liu ◽  
Toshiya Tachibana ◽  
Yi Dai ◽  
Eiji Kondo ◽  
Tetsuo Fukuoka ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
Cord Injury ◽  
Activated Neutrophils
Sign in / Sign up

Export Citation Format

Share Document