scholarly journals Astrocyte-specific heme oxygenase-1 hyperexpression attenuates heme-mediated oxidative injury

2007 ◽  
Vol 26 (3) ◽  
pp. 688-695 ◽  
Author(s):  
Luna Benvenisti-Zarom ◽  
Raymond F. Regan
Keyword(s):  
Heme Oxygenase ◽  
Oxidative Injury ◽  
Heme Oxygenase 1

Heme Oxygenase-1 protects astroglia against manganese-induced oxidative injury by regulating mitochondrial quality control

2018 ◽  
Vol 295 ◽  
pp. 357-368 ◽  
Author(s):  
Roxana Mayra Gorojod ◽  
Agustina Alaimo ◽  
Soledad Porte Alcon ◽  
Jimena Hebe Martinez ◽  
María Eugenia Cortina ◽  
...  
Keyword(s):  
Quality Control ◽  
Heme Oxygenase ◽  
Oxidative Injury ◽  
Heme Oxygenase 1 ◽  
Mitochondrial Quality Control

scholarly journals Antimelanoma activities of chimeric thiazole–androstenone derivatives

2021 ◽  
Vol 8 (8) ◽  
pp. 210395
Author(s):  
Steven A. Chambers ◽  
Mathew Newman ◽  
Melissa M. Frangie ◽  
Alena V. Savenka ◽  
Alexei. G. Basnakian ◽  
...  
Keyword(s):  
Growth Inhibition ◽  
Heme Oxygenase ◽  
Oxidative Injury ◽  
Melanoma Cells ◽  
Tunel Assay ◽  
Heme Oxygenase 1 ◽  
Endonuclease G ◽  
Caspase Activated Dnase ◽  
Potent Growth

The discovery of chimeric anti-melanoma agents is reported. These molecules are potent growth suppressors of melanoma cells in vitro with growth inhibition of 50% (GI 50 ) values as low as 1.32 µM. Compounds were more toxic to melanoma cells in vitro than commonly used anti-melanoma agent dacarbazine as measured by TUNEL assay. They induced both caspase-independent apoptosis evident by colocalization of TUNEL with endonuclease G (EndoG) and caspase-mediated apoptosis measured by colocalization of TUNEL with caspase-activated DNase (CAD). In addition, compounds 3 and 5 strongly induced oxidative injury to melanoma cells as measured by TUNEL colocalization with heme oxygenase-1 (HO1). Dacarbazine induced only caspase-independent apoptosis, which may explain why it is less cytotoxic to melanoma cells than compounds 3 , 4 and 5 .

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