Overexpression of heme oxygenase-1 (HO-1) in V79 cells results in increased resistance to hyperbaric oxygen (HBO)-induced DNA damage

2002 ◽  
Vol 40 (4) ◽  
pp. 258-265 ◽  
Author(s):  
Andreas Rothfuss ◽  
G�nter Speit
Keyword(s):  
Dna Damage ◽  
Hyperbaric Oxygen ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1 ◽  
V79 Cells

scholarly journals Hyperbaric Oxygen Preconditioning Upregulates Heme OxyGenase-1 and Anti-Apoptotic Bcl-2 Protein Expression in Spontaneously Hypertensive Rats with Induced Postischemic Acute Kidney Injury

2021 ◽  
Vol 22 (3) ◽  
pp. 1382
Author(s):  
Jelena Nesovic Ostojic ◽  
Milan Ivanov ◽  
Nevena Mihailovic-Stanojevic ◽  
Danijela Karanovic ◽  
Sanjin Kovacevic ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Protein Expression ◽  
Hyperbaric Oxygen ◽  
Heme Oxygenase ◽  
Spontaneously Hypertensive Rats ◽  
Wistar Rats ◽  
Kidney Injury ◽  
Heme Oxygenase 1 ◽  
Hypertensive Rats ◽  
Spontaneously Hypertensive

Renal ischemia and reperfusion (I/R) injury is the most common cause of acute kidney injury (AKI). Pathogenesis of postischemic AKI involves hemodynamic changes, oxidative stress, inflammation process, calcium ion overloading, apoptosis and necrosis. Up to date, therapeutic approaches to treat AKI are extremely limited. Thus, the aim of this study was to evaluate the effects of hyperbaric oxygen (HBO) preconditioning on citoprotective enzyme, heme oxygenase-1 (HO-1), pro-apoptotic Bax and anti-apoptotic Bcl-2 proteins expression, in postischemic AKI induced in normotensive Wistar and spontaneously hypertensive rats (SHR). The animals were randomly divided into six experimental groups: SHAM-operated Wistar rats (W-SHAM), Wistar rats with induced postischemic AKI (W-AKI) and Wistar group with HBO preconditioning before AKI induction (W-AKI + HBO). On the other hand, SHR rats were also divided into same three groups: SHR-SHAM, SHR-AKI and SHR-AKI + HBO. We demonstrated that HBO preconditioning upregulated HO-1 and anti-apoptotic Bcl-2 protein expression, in both Wistar and SH rats. In addition, HBO preconditioning improved glomerular filtration rate, supporting by significant increase in creatinine, urea and phosphate clearances in both rat strains. Considering our results, we can also say that even in hypertensive conditions, we can expect protective effects of HBO preconditioning in experimental model of AKI.

scholarly journals Early heme oxygenase 1 induction delays tumour initiation and enhances DNA damage repair in liver macrophages of Mdr2−/− mice

2018 ◽  
Vol 8 (1) ◽  
Author(s):  
Roja Barikbin ◽  
Laura Berkhout ◽  
Julia Bolik ◽  
Dirk Schmidt-Arras ◽  
Thomas Ernst ◽  
...  
Keyword(s):  
Dna Damage ◽  
Heme Oxygenase ◽  
Dna Damage Repair ◽  
Heme Oxygenase 1 ◽  
Liver Macrophages ◽  
Damage Repair ◽  
Tumour Initiation

863 HEME OXYGENASE-1 AND CARBON MONOXIDE MODULATE RESPONSES TO DNA DAMAGE AND ARREST TUMOUR GROWTH

2010 ◽  
Vol 9 (2) ◽  
pp. 273-274
Author(s):  
B. Weaiel ◽  
A. Bjartell ◽  
C. Harris ◽  
J. Belcher ◽  
G. Vercellotti ◽  
...  
Keyword(s):  
Dna Damage ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Tumour Growth ◽  
Heme Oxygenase 1

Abstract C41: Heme oxygenase‐1 and carbon monoxide modulate responses to DNA damage in prostate cancer

2009 ◽  
Author(s):  
Barbara Wegiel ◽  
Anders Bjartell ◽  
Clair Harris ◽  
John Belcher ◽  
Gregory Vercellotti ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Dna Damage ◽  
Carbon Monoxide ◽  
Heme Oxygenase ◽  
Heme Oxygenase 1
Sign in / Sign up

Export Citation Format

Share Document