scholarly journals Pilot assessment of a human extracellular matrix-based vascular graft in a rabbit model

2017 ◽  
Vol 65 (3) ◽  
pp. 839-847.e1 ◽  
Author(s):  
Salma Amensag ◽  
Leslie A. Goldberg ◽  
Kerri A. O'Malley ◽  
Demaretta S. Rush ◽  
Scott A. Berceli ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft ◽  
Rabbit Model

scholarly journals Cartilage Extracellular Matrix Scaffold With Kartogenin-Encapsulated PLGA Microspheres for Cartilage Regeneration

2020 ◽  
Vol 8 ◽  
Author(s):  
Yanhong Zhao ◽  
Xige Zhao ◽  
Rui Zhang ◽  
Ying Huang ◽  
Yunjie Li ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Composite Scaffold ◽  
Rabbit Model ◽  
Cartilage Tissue ◽  
Cartilage Defects ◽  
Specific Marker ◽  
Molecular Compound ◽  
Plga Microspheres

Repair of articular cartilage defects is a challenging aspect of clinical treatment. Kartogenin (KGN), a small molecular compound, can induce the differentiation of bone marrow-derived mesenchymal stem cells (BMSCs) into chondrocytes. Here, we constructed a scaffold based on chondrocyte extracellular matrix (CECM) and poly(lactic-co-glycolic acid) (PLGA) microspheres (MP), which can slowly release KGN, thus enhancing its efficiency. Cell adhesion, live/dead staining, and CCK-8 results indicated that the PLGA(KGN)/CECM scaffold exhibited good biocompatibility. Histological staining and quantitative analysis demonstrated the ability of the PLGA(KGN)/CECM composite scaffold to promote the differentiation of BMSCs. Macroscopic observations, histological tests, and specific marker analysis showed that the regenerated tissues possessed characteristics similar to those of normal hyaline cartilage in a rabbit model. Use of the PLGA(KGN)/CECM scaffold may mimic the regenerative microenvironment, thereby promoting chondrogenic differentiation of BMSCs in vitro and in vivo. Therefore, this innovative composite scaffold may represent a promising approach for acellular cartilage tissue engineering.

scholarly journals Extracellular matrix remodeling after balloon angioplasty injury in a rabbit model of restenosis.

1994 ◽  
Vol 75 (4) ◽  
pp. 650-658 ◽  
Author(s):  
B H Strauss ◽  
R J Chisholm ◽  
F W Keeley ◽  
A I Gotlieb ◽  
R A Logan ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Balloon Angioplasty ◽  
Rabbit Model ◽  
Extracellular Matrix Remodeling ◽  
Matrix Remodeling

scholarly journals Submillimeter Diameter Poly(Vinyl Alcohol) Vascular Graft Patency in Rabbit Model

2016 ◽  
Vol 4 ◽  
Author(s):  
Marie F. A. Cutiongco ◽  
Marek Kukumberg ◽  
Jonnathan L. Peneyra ◽  
Matthew S. Yeo ◽  
Jia Y. Yao ◽  
...  
Keyword(s):  
Vinyl Alcohol ◽  
Vascular Graft ◽  
Rabbit Model ◽  
Graft Patency ◽  
Poly Vinyl Alcohol

scholarly journals Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials

2016 ◽  
Vol 25 ◽  
pp. 31-37 ◽  
Author(s):  
D.N. Coakley ◽  
F.M. Shaikh ◽  
K. O'Sullivan ◽  
E.G. Kavanagh ◽  
P.A. Grace ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft ◽  
Synthetic Vascular Graft

scholarly journals Extracellular Matrix Gene Expression after Vocal Fold Injury in a Rabbit Model

2008 ◽  
Vol 117 (8) ◽  
pp. 598-603 ◽  
Author(s):  
Bernard Rousseau ◽  
Ping Jiang Ge ◽  
Tsunehisa Ohno ◽  
Lesley C. French ◽  
Susan L. Thibeault
Keyword(s):  
Gene Expression ◽  
Extracellular Matrix ◽  
Vocal Fold ◽  
Rabbit Model ◽  
Matrix Gene

scholarly journals Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction

2017 ◽  
Vol 6 (10) ◽  
pp. 1601333 ◽  
Author(s):  
Qi Xing ◽  
Zichen Qian ◽  
Mitchell Tahtinen ◽  
Ai Hui Yap ◽  
Keegan Yates ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft

scholarly journals A Novel Treponema pallidum Antigen, TP0136, Is an Outer Membrane Protein That Binds Human Fibronectin

2008 ◽  
Vol 76 (5) ◽  
pp. 1848-1857 ◽  
Author(s):  
Mary Beth Brinkman ◽  
Melanie A. McGill ◽  
Jonas Pettersson ◽  
Arthur Rogers ◽  
Petra Matějková ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Outer Membrane ◽  
Protective Antigen ◽  
Rabbit Model ◽  
Treponema Pallidum ◽  
Reading Frame ◽  
Extracellular Matrix Components ◽  
Human Fibronectin ◽  
Bacterial Outer Membrane ◽  
And Function

ABSTRACT The antigenicity, structural location, and function of the predicted lipoprotein TP0136 of Treponema pallidum subsp. pallidum were investigated based on previous screening studies indicating that anti-TP0136 antibodies are present in the sera of syphilis patients and experimentally infected rabbits. Recombinant TP0136 (rTP0136) protein was purified and shown to be strongly antigenic during human and experimental rabbit infection. The TP0136 protein was exposed on the surface of the bacterial outer membrane and bound to the host extracellular matrix glycoproteins fibronectin and laminin. In addition, the TP0136 open reading frame was shown to be highly polymorphic among T. pallidum subspecies and strains at the nucleotide and amino acid levels. Finally, the ability of rTP0136 protein to act as a protective antigen to subsequent challenge with infectious T. pallidum in the rabbit model of infection was assessed. Immunization with rTP0136 delayed ulceration but did not prevent infection or the formation of lesions. These results demonstrate that TP0136 is expressed on the outer membrane of the treponeme during infection and may be involved in attachment to host extracellular matrix components.

Mechanical and Chemical Stimulation of Bone-Marrow Stem Cells in a Three-Dimensional Fibrin Matrix: Preliminary Results

2008 ◽  
Author(s):  
Jessica L. LoSurdo ◽  
Douglas W. Chew ◽  
Alejandro Nieponice ◽  
David A. Vorp
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Marrow ◽  
Extracellular Matrix ◽  
Vascular Graft ◽  
Three Dimensional ◽  
Chemical Stimulation ◽  
Alternative Source ◽  
Immunological Rejection ◽  
Stimulation Of

The primary goal of tissue engineering is to develop a biological, mechanically-robust, and anti-thrombogenic vascular graft to replace diseased or damaged tissue and organs [1]. For example, researchers have incorporated smooth muscle cells (SMCs) into extracellular matrix to provide a living, functional conduits with the intended purpose of replacing SMC-containing tubes, such as the blood vessel, urethra, esophagus, intestine, etc. Although the preferred source is autologous cells to avoid immunological rejection, adult SMCs are difficult to obtain and expand. An alternative source of autologous cells could be bone marrow derived stem cells (BMSCs), which differentiate toward mesenchymal and hematopoietic lineages [2].

Abstract 132: Application of a Cryogel-Coated Prosthetic Vascular Graft Material for Delivery of Targeted Gene Therapies in a Rabbit Model

2018 ◽  
Vol 38 (Suppl_1) ◽  
Author(s):  
Cindy Huynh ◽  
Ting Shih ◽  
Mauricio Contreras ◽  
David Mooney ◽  
Leena Pradhan-Nabzdyk ◽  
...  
Keyword(s):  
Vascular Graft ◽  
Rabbit Model ◽  
Graft Material ◽  
Gene Therapies
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