scholarly journals Submillimeter Diameter Poly(Vinyl Alcohol) Vascular Graft Patency in Rabbit Model

Author(s):  
Marie F. A. Cutiongco ◽  
Marek Kukumberg ◽  
Jonnathan L. Peneyra ◽  
Matthew S. Yeo ◽  
Jia Y. Yao ◽  
...  
2019 ◽  
Vol 3 (1) ◽  
pp. 693-703 ◽  
Author(s):  
Muhammad Rizwan ◽  
Yuan Yao ◽  
Maud B. Gorbet ◽  
John W. Tse ◽  
Deirdre E. J. Anderson ◽  
...  

2021 ◽  
Vol 7 ◽  
Author(s):  
YeJin Jeong ◽  
Yuan Yao ◽  
Tizazu H. Mekonnen ◽  
Evelyn K. F. Yim

Poly(vinyl alcohol) (PVA) is a water-soluble polymer and forms a hydrogel that has been studied as a potential small-diameter (<6 mm) vascular graft implant. The PVA hydrogel crosslinked using sodium trimetaphosphate (STMP) has been shown to have many beneficial properties such as bioinert, low-thrombogenicity, and easy surface modification. Compared to conventional synthetic vascular graft materials, PVA has also shown to possess better mechanical properties; however, the compliance and other mechanical properties of PVA grafts are yet to be optimized to be comparable with native blood vessels. Mechanical compliance has been an important parameter to be studied for small-diameter vascular grafts, as compliance has been proposed to play an important role in intimal hyperplasia formation. PVA grafts are made using dip-casting a cylindrical mold into crosslinking solution. The number of dipping can be used to control the wall thickness of the resulting PVA grafts. In this study, we hypothesized that the number of dip layers, chemical and physical crosslinking, and interlayer adhesion strength could be important parameters in the fabrication process that would affect compliance. This work provides the relationship between the wall thickness, burst pressure, and compliance of PVA. Furthermore, our data showed that interlayer adhesion as well as chemical and physical crosslinking density can increase the compliance of PVA grafts.


1986 ◽  
Vol 1 (6) ◽  
pp. 861-869 ◽  
Author(s):  
Paul D. Garrett ◽  
David T. Grubb

2019 ◽  
Vol 18 (1) ◽  
pp. 125-136 ◽  
Author(s):  
Luiza Jecu ◽  
Iuliana Raut ◽  
Elena Grosu ◽  
Mariana Calin ◽  
Violeta Purcar ◽  
...  

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