scholarly journals Aligned Nanofibrous Cell-Derived Extracellular Matrix for Anisotropic Vascular Graft Construction

2017 ◽  
Vol 6 (10) ◽  
pp. 1601333 ◽  
Author(s):  
Qi Xing ◽  
Zichen Qian ◽  
Mitchell Tahtinen ◽  
Ai Hui Yap ◽  
Keegan Yates ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft

scholarly journals Comparing the endothelialisation of extracellular matrix bioscaffolds with coated synthetic vascular graft materials

2016 ◽  
Vol 25 ◽  
pp. 31-37 ◽  
Author(s):  
D.N. Coakley ◽  
F.M. Shaikh ◽  
K. O'Sullivan ◽  
E.G. Kavanagh ◽  
P.A. Grace ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft ◽  
Synthetic Vascular Graft

scholarly journals Pilot assessment of a human extracellular matrix-based vascular graft in a rabbit model

2017 ◽  
Vol 65 (3) ◽  
pp. 839-847.e1 ◽  
Author(s):  
Salma Amensag ◽  
Leslie A. Goldberg ◽  
Kerri A. O'Malley ◽  
Demaretta S. Rush ◽  
Scott A. Berceli ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft ◽  
Rabbit Model

Mechanical and Chemical Stimulation of Bone-Marrow Stem Cells in a Three-Dimensional Fibrin Matrix: Preliminary Results

2008 ◽  
Author(s):  
Jessica L. LoSurdo ◽  
Douglas W. Chew ◽  
Alejandro Nieponice ◽  
David A. Vorp
Keyword(s):  
Tissue Engineering ◽  
Stem Cells ◽  
Bone Marrow ◽  
Extracellular Matrix ◽  
Vascular Graft ◽  
Three Dimensional ◽  
Chemical Stimulation ◽  
Alternative Source ◽  
Immunological Rejection ◽  
Stimulation Of

The primary goal of tissue engineering is to develop a biological, mechanically-robust, and anti-thrombogenic vascular graft to replace diseased or damaged tissue and organs [1]. For example, researchers have incorporated smooth muscle cells (SMCs) into extracellular matrix to provide a living, functional conduits with the intended purpose of replacing SMC-containing tubes, such as the blood vessel, urethra, esophagus, intestine, etc. Although the preferred source is autologous cells to avoid immunological rejection, adult SMCs are difficult to obtain and expand. An alternative source of autologous cells could be bone marrow derived stem cells (BMSCs), which differentiate toward mesenchymal and hematopoietic lineages [2].

scholarly journals Biodegradable small-diameter vascular graft: types of modification with bioactive molecules and RGD peptides

2020 ◽  
Vol 22 (1) ◽  
pp. 86-96
Author(s):  
E. A. Senokosova ◽  
E. O. Krivkina ◽  
L. V. Antonova ◽  
L. S. Barbarash
Keyword(s):  
Extracellular Matrix ◽  
Endothelial Cells ◽  
Vascular Graft ◽  
Vascular Tissue ◽  
Polymer Surface ◽  
Small Diameter ◽  
Rgd Peptide ◽  
Bioactive Molecules ◽  
Polymer Composition ◽  
Inner Surface

The need for small-diameter grafts for replacing the damaged area of the blood pool is still very high. These grafts are very popular for coronary artery bypass grafting. Polymeric synthetic grafts are an alternative to autografts. A promising area of tissue engineering is the creation of a biodegradable graft. It can serve as the basis for de novo generation of vascular tissue directly in the patient’s body. Optimization of the polymer composition of products has led to improved physicomechanical and biocompatible properties of the products. However, the improvements are still far from needed. One of the decisive factors in the reliability of a small-diameter vascular graft is the early formation of endothelial lining on its inner surface, which can provide atrombogenic effect and full lumen of the future newly formed vessel. To achieve this goal, grafts are modified by incorporating bioactive molecules or functionally active peptide sequences into the polymer composition or immobilizing on its inner surface. Peptide sequences include cell adhesion site – arginine-glycine-aspartic acid (RGD peptide). This sequence is present in most extracellular matrix proteins and has a tropism for integrin receptors of endothelial cells. Many studies have shown that imitation of the functional activity of the natural extracellular matrix can promote spontaneous endothelization of the inner surface of a vascular graft. Moreover, configuration of the RGD peptide determines the survival and differentiation of endothelial cells. The linker through which the peptide is crosslinked to the polymer surface determines the bioavailability of the RGD peptide for endothelial cells.

scholarly journals Assessment of decellularized pericardial extracellular matrix and poly(propylene fumarate) biohybrid for small-diameter vascular graft applications

2020 ◽  
Vol 110 ◽  
pp. 68-81 ◽  
Author(s):  
Megan Kimicata ◽  
Jules D. Allbritton-King ◽  
Javier Navarro ◽  
Marco Santoro ◽  
Takahiro Inoue ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Vascular Graft ◽  
Small Diameter ◽  
Poly Propylene

Cardiac myocytes cultured on a basement membrane extract of the ehs tumor

1986 ◽  
Vol 44 ◽  
pp. 270-271
Author(s):  
L. Terracio ◽  
A. Dewey ◽  
K. Rubin ◽  
T.K. Borg
Keyword(s):  
Extracellular Matrix ◽  
Basement Membrane ◽  
Cardiac Myocytes ◽  
Normal Tissue ◽  
Cell Spreading ◽  
Collagen Iv ◽  
Basement Membrane Extract ◽  
Membrane Extract ◽  
Growth Development ◽  
Multicellular Organisms

The recognition and interaction of cells with the extracellular matrix (ECM) effects the normal physiology as well as the pathology of all multicellular organisms. These interactions have been shown to influence the growth, development, and maintenance of normal tissue function. In previous studies, we have shown that neonatal cardiac myocytes specifically interacts with a variety of ECM components including fibronectin, laminin, and collagens I, III and IV. Culturing neonatal myocytes on laminin and collagen IV induces an increased rate of both cell spreading and sarcomerogenesis.

Neutrophil migration through in vitro interstitial matrix

1992 ◽  
Vol 50 (1) ◽  
pp. 894-895
Author(s):  
J. Roemer ◽  
S.R. Simon
Keyword(s):  
Extracellular Matrix ◽  
Smooth Muscle ◽  
Cell Migration ◽  
Smooth Muscle Cells ◽  
Inflammatory Cell ◽  
Neutrophil Migration ◽  
Culture Conditions ◽  
Aortic Smooth Muscle ◽  
Specific Culture

We are developing an in vitro interstitial extracellular matrix (ECM) system for study of inflammatory cell migration. Falcon brand Cyclopore membrane inserts of various pore sizes are used as a support substrate for production of ECM by R22 rat aortic smooth muscle cells. Under specific culture conditions these cells produce a highly insoluble matrix consisting of typical interstitial ECM components, i.e.: types I and III collagen, elastin, proteoglycans and fibronectin.

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