scholarly journals p53 Overexpression is a Predictor of Local Recurrence After Treatment for Both in situ and Invasive Ductal Carcinoma of the Breast

2007 ◽  
Vol 140 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Marnix A. de Roos ◽  
Geertruida H. de Bock ◽  
Jaap de Vries ◽  
Bert van der Vegt ◽  
Jelle Wesseling
Keyword(s):  
Local Recurrence ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
P53 Overexpression

Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast

2009 ◽  
pp. NA-NA
Author(s):  
Gil Facina ◽  
Pedro Vitor Lopes-Costa ◽  
Alesse Ribeiro Dos Santos ◽  
Rodrigo Jose De Vasconcelos-Valença ◽  
André Luis Pinho-Sobral ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Immunohistochemical Expression ◽  
Carcinoma Of The Breast ◽  
Sclerosing Adenosis ◽  
E Cadherin

scholarly journals Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast

2012 ◽  
Vol 51 (12) ◽  
pp. 1067-1078 ◽  
Author(s):  
Shaoxi Liao ◽  
Mohamed M. Desouki ◽  
Daniel P. Gaile ◽  
Lori Shepherd ◽  
Norma J. Nowak ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Invasive Ductal Carcinoma ◽  
Copy Number ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Copy Number Aberrations

Initial Margin Status for Invasive Ductal Carcinoma of the Breast and Subsequent Identification of Carcinoma in Reexcision Specimens

2010 ◽  
Vol 134 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Silvia Skripenova ◽  
Lester J. Layfield
Keyword(s):  
Local Recurrence ◽  
Invasive Ductal Carcinoma ◽  
Invasive Carcinoma ◽  
Ductal Carcinoma ◽  
Excisional Biopsy ◽  
Margin Status ◽  
Carcinoma Of The Breast ◽  
Residual Carcinoma ◽  
Invasive Carcinomas ◽  
Subsequent Identification

Abstract Context. Margin status of lumpectomy specimens is related to frequency of local recurrence. Optimal surgical technique requires microscopic margins free of carcinoma by at least 2 mm. Recurrence following lumpectomy is associated with residual carcinoma secondary to inadequate resection. Objective. To review our series of breast excisions to determine the frequency of residual carcinoma for positive, close, and negative margins. Design. We reviewed lumpectomies and excisional biopsies for invasive ductal carcinoma that had subsequent reexcisions. Margin status of specimens was recorded as positive, less than 1 mm, 1 to 2 mm, or greater than 2 mm. Results. A total of 123 lumpectomies and excisional biopsies of invasive ductal carcinoma with reexcision were reviewed. Residual invasive carcinoma was found in 44% (17), 25% (6), 28% (8), and 16% (5) of cases with positive, less than 1 mm, 1 to 2 mm, and greater than 2 mm margins, respectively. Residual invasive carcinomas were found in 57% (8), 100% (5), 67% (2), and 100% (2) of mastectomies with positive, less than 1 mm, 1 to 2 mm, and greater than 2 mm margins, respectively, in the initial lumpectomy or excisional biopsy. Conclusions. Frequency of residual invasive carcinoma was related to margin status of the original lumpectomy/biopsy. Even when margins were positive, most reexcisions were free of carcinoma. Residual invasive carcinoma was found in greater than 25% of patients with margins less than 2 mm, supporting reexcision for patients with margins of less than 2 mm. Sixteen percent of cases with margins greater than 2 mm harbored residual invasive carcinoma. Evaluation of margin status was complicated by tissue distortion and fragmentation.

scholarly journals Accuracy of Digital Image Analysis (DIA) of Borderline Human Epidermal Growth Factor Receptor (HER2) Immunohistochemistry in Invasive Ductal Carcinoma

2020 ◽  
Vol 13 (9) ◽  
Author(s):  
Nema Mohamadian Roshan ◽  
Sepideh Salehabadi ◽  
Melika Kooshki Forooshani ◽  
Azin Nikoozadeh
Keyword(s):  
Image Analysis ◽  
Epidermal Growth Factor Receptor ◽  
In Situ Hybridization ◽  
Invasive Ductal Carcinoma ◽  
Digital Image Analysis ◽  
Ductal Carcinoma ◽  
Growth Factor Receptor ◽  
Carcinoma Of The Breast ◽  
Epidermal Growth

Background: Digital image analysis (DIA), used to extract information from pathology slides, provides better precision and no limitation regarding different interpretations by observers. Objectives: The present study aimed at evaluating the accuracy of DIA in the interpretation of borderline (2+) human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) slides of invasive ductal carcinoma of the breast. Methods: Sixty pathology samples with invasive ductal carcinoma of the breast were extracted based on HER2 (2+) and their fluorescence in situ hybridization (FISH), and chromogenic in situ hybridization (CISH) responses (as reference standard). The slides were digitized and, then, two pathologists examined the slides and documented diagnosis. DIA was performed by a free web application. Results: Totally, 307 digital images with 298 megabytes volume were extracted. The accuracy, sensitivity, and specificity values of DIA were 86 %, 46.1 %, and 97.8 %, respectively, with 8 false-negative cases. There was moderate agreement between the pathologist 1 (kappa = 0.42) and pathologist 2 (kappa = 0.41) with DIA. Conclusions: DIA had good accuracy and could be used for the interpretation of borderline HER2 IHC method in invasive ductal carcinoma.

20q13.2 Amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast

1999 ◽  
Vol 435 (5) ◽  
pp. 469-472 ◽  
Author(s):  
M. Werner ◽  
Anita Mattis ◽  
Michaela Aubele ◽  
Margaret Cummings ◽  
Horst Zitzelsberger ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast
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