20q13.2 Amplification in intraductal hyperplasia adjacent to in situ and invasive ductal carcinoma of the breast

1999 ◽  
Vol 435 (5) ◽  
pp. 469-472 ◽  
Author(s):  
M. Werner ◽  
Anita Mattis ◽  
Michaela Aubele ◽  
Margaret Cummings ◽  
Horst Zitzelsberger ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast

Immunohistochemical expression of E-cadherin in sclerosing adenosis, ductal carcinoma in situ and invasive ductal carcinoma of the breast

2009 ◽  
pp. NA-NA
Author(s):  
Gil Facina ◽  
Pedro Vitor Lopes-Costa ◽  
Alesse Ribeiro Dos Santos ◽  
Rodrigo Jose De Vasconcelos-Valença ◽  
André Luis Pinho-Sobral ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma In Situ ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Immunohistochemical Expression ◽  
Carcinoma Of The Breast ◽  
Sclerosing Adenosis ◽  
E Cadherin

scholarly journals Differential copy number aberrations in novel candidate genes associated with progression from in situ to invasive ductal carcinoma of the breast

2012 ◽  
Vol 51 (12) ◽  
pp. 1067-1078 ◽  
Author(s):  
Shaoxi Liao ◽  
Mohamed M. Desouki ◽  
Daniel P. Gaile ◽  
Lori Shepherd ◽  
Norma J. Nowak ◽  
...  
Keyword(s):  
Candidate Genes ◽  
Invasive Ductal Carcinoma ◽  
Copy Number ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
Copy Number Aberrations

scholarly journals Accuracy of Digital Image Analysis (DIA) of Borderline Human Epidermal Growth Factor Receptor (HER2) Immunohistochemistry in Invasive Ductal Carcinoma

2020 ◽  
Vol 13 (9) ◽  
Author(s):  
Nema Mohamadian Roshan ◽  
Sepideh Salehabadi ◽  
Melika Kooshki Forooshani ◽  
Azin Nikoozadeh
Keyword(s):  
Image Analysis ◽  
Epidermal Growth Factor Receptor ◽  
In Situ Hybridization ◽  
Invasive Ductal Carcinoma ◽  
Digital Image Analysis ◽  
Ductal Carcinoma ◽  
Growth Factor Receptor ◽  
Carcinoma Of The Breast ◽  
Epidermal Growth

Background: Digital image analysis (DIA), used to extract information from pathology slides, provides better precision and no limitation regarding different interpretations by observers. Objectives: The present study aimed at evaluating the accuracy of DIA in the interpretation of borderline (2+) human epidermal growth factor receptor 2 (HER2) immunohistochemistry (IHC) slides of invasive ductal carcinoma of the breast. Methods: Sixty pathology samples with invasive ductal carcinoma of the breast were extracted based on HER2 (2+) and their fluorescence in situ hybridization (FISH), and chromogenic in situ hybridization (CISH) responses (as reference standard). The slides were digitized and, then, two pathologists examined the slides and documented diagnosis. DIA was performed by a free web application. Results: Totally, 307 digital images with 298 megabytes volume were extracted. The accuracy, sensitivity, and specificity values of DIA were 86 %, 46.1 %, and 97.8 %, respectively, with 8 false-negative cases. There was moderate agreement between the pathologist 1 (kappa = 0.42) and pathologist 2 (kappa = 0.41) with DIA. Conclusions: DIA had good accuracy and could be used for the interpretation of borderline HER2 IHC method in invasive ductal carcinoma.

scholarly journals p53 Overexpression is a Predictor of Local Recurrence After Treatment for Both in situ and Invasive Ductal Carcinoma of the Breast

2007 ◽  
Vol 140 (1) ◽  
pp. 109-114 ◽  
Author(s):  
Marnix A. de Roos ◽  
Geertruida H. de Bock ◽  
Jaap de Vries ◽  
Bert van der Vegt ◽  
Jelle Wesseling
Keyword(s):  
Local Recurrence ◽  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma ◽  
Carcinoma Of The Breast ◽  
P53 Overexpression

scholarly journals Clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with ductal carcinoma in situ (DCIS): a multi-institutional retrospective cohort study

Breast Cancer ◽  
2021 ◽  
Author(s):  
Kiyo Tanaka ◽  
Norikazu Masuda ◽  
Naoki Hayashi ◽  
Yasuaki Sagara ◽  
Fumikata Hara ◽  
...  
Keyword(s):  
Invasive Ductal Carcinoma ◽  
Ductal Carcinoma In Situ ◽  
Tumor Size ◽  
Medical Records ◽  
Carcinoma In Situ ◽  
Ductal Carcinoma ◽  
Palpable Mass ◽  
Combined Use ◽  
A Prospective Study

Abstract Background We conducted a prospective study with the intention to omit surgery for patients with ductal carcinoma in situ (DCIS) of the breast. We aimed to identify clinicopathological predictors of postoperative upstaging to invasive ductal carcinoma (IDC) in patients preoperatively diagnosed with DCIS. Patients and methods We retrospectively analyzed patients with DCIS diagnosed through biopsy between April 1, 2010 and December 31, 2014, from 16 institutions. Clinical, radiological, and histological variables were collected from medical records. Results We identified 2,293 patients diagnosed with DCIS through biopsy, including 1,663 DCIS (72.5%) cases and 630 IDC (27.5%) cases. In multivariate analysis, the presence of a palpable mass (odds ratio [OR] 1.8; 95% confidence interval [CI] 1.2–2.6), mammography findings (≥ category 4; OR 1.8; 95% CI 1.2–2.6), mass formations on ultrasonography (OR 1.8; 95% CI 1.2–2.5), and tumor size on MRI (> 20 mm; OR 1.7; 95% CI 1.2–2.4) were independent predictors of IDC. Among patients with a tumor size on MRI of ≤ 20 mm, the possibility of postoperative upstaging to IDC was 22.1%. Among the 258 patients with non-palpable mass, nuclear grade 1/2, and positive for estrogen receptor, the possibility was 18.1%, even if the upper limit of the tumor size on MRI was raised to ≤ 40 mm. Conclusion We identified four independent predictive factors of upstaging to IDC after surgery among patients with DCIS diagnosed by biopsy. The combined use of various predictors of IDC reduces the possibility of postoperative upstaging to IDC, even if the tumor size on MRI is larger than 20 mm.

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