Current advances in proteomic analysis of (fatty) liver

2012 ◽  
Vol 75 (14) ◽  
pp. 4290-4295 ◽  
Author(s):  
C. Molette ◽  
L. Théron ◽  
N. Marty-Gasset ◽  
X. Fernandez ◽  
H. Rémignon
Keyword(s):  
Fatty Liver ◽  
Proteomic Analysis

scholarly journals Integrative proteomic and lipidomic analysis of Kaili Sour Soup-mediated attenuation of high-fat diet-induced nonalcoholic fatty liver disease in a rat model

2021 ◽  
Vol 18 (1) ◽  
Author(s):  
Shuo Cong ◽  
Zhengchao Li ◽  
Lei Yu ◽  
Yongmei Liu ◽  
Yaxin Hu ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Rat Model ◽  
Proteomic Analysis ◽  
High Fat Diet ◽  
Fatty Liver Disease ◽  
High Fat ◽  
Nonalcoholic Fatty Liver ◽  
Lipidomic Analysis

Abstract Background Nonalcoholic fatty liver disease (NAFLD) is the most prevalent liver disease and is characterized by excessive fat accumulation. Kaili Sour Soup, a food typical of Guizhou Province, is believed to have significant health benefits. Thus, we aimed to identify and assess the impact of Kaili Sour Soup on NAFLD and its underlying mechanism using integrative proteomic and lipidomic analysis. Methods A high-fat diet and male Wistar rats were used to construct a NAFLD rat model. Haematoxylin and eosin (HE) and Oil Red O staining analyses were used to perform the histologic examination. Proteomic analysis was utilized to systematically identify the global protein profile in NAFLD with and without Kaili Sour Soup treatment. Western blot assays were used to verify the expression of proteins screened by proteomic analysis. Lipidomic analysis was performed to screen lipid metabolism in NAFLD with and without Kaili Sour Soup treatment. Results Kaili Sour Soup alleviated high-fat diet (HFD)-induced fatty liver and had a normalizing effect on physiological and biochemical indicators of NAFLD, including body weight, liver weight, liver index, total cholesterol (TC), triglyceride (TG), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and insulin resistance level of homeostasis model assessment (HOMA-IR). Kaili Sour Soup decreased the levels of 13 proteins (Tmem44, Rnaseh2b, Gstm6l, LOC100910877, Rufy4, Slc12a2, Pcif1, P4503A1, Sult1e1, Nop53, AABR07065656.4, AABR07065789.3) that were upregulated by HFD and increased the levels of 3 proteins (Sult1c2, Sult1c2a, Snrnp48) that were downregulated by HFD. Kaili Sour Soup attenuated the HFD-induced increase in acyl carnitine (AcCa) and enhanced the HFD-induced decreases in gangliosides (GM3) and lysophosphatidylserine (LPS) in the NAFLD rat model. Conclusions Altogether, this study revealed that Kaili Sour Soup attenuated HFD-induced fatty liver and systematically identified abnormal proteins and lipids involved in the role of Kaili Sour Soup in a NAFLD rat model.

scholarly journals Proteomic analysis of fructose-induced fatty liver in hamsters

Metabolism ◽  
2008 ◽  
Vol 57 (8) ◽  
pp. 1115-1124 ◽  
Author(s):  
Lihe Zhang ◽  
German Perdomo ◽  
Dae Hyun Kim ◽  
Shen Qu ◽  
Steven Ringquist ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Proteomic Analysis

Proteomic Analysis of Duck Fatty Liver during Post-Mortem Storage Related to the Variability of Fat Loss during Cooking of “Foie Gras”

2013 ◽  
Vol 61 (4) ◽  
pp. 920-930 ◽  
Author(s):  
Laetitia Theron ◽  
Xavier Fernandez ◽  
Nathalie Marty-Gasset ◽  
Christophe Chambon ◽  
Didier Viala ◽  
...  
Keyword(s):  
Fatty Liver ◽  
Proteomic Analysis ◽  
Post Mortem ◽  
Fat Loss ◽  
Foie Gras
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