Comparative proteomic analysis using 2DE-LC-MS/MS reveals the mechanism of Fuzhuan brick tea extract against hepatic fat accumulation in rats with nonalcoholic fatty liver disease

2015 ◽  
Vol 36 (17) ◽  
pp. 2002-2016 ◽  
Author(s):  
Zhonghua Liu ◽  
Yong Lin ◽  
Sheng Zhang ◽  
Die Wang ◽  
Qionglin Liang ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Proteomic Analysis ◽  
Fatty Liver Disease ◽  
Fat Accumulation ◽  
Nonalcoholic Fatty Liver ◽  
Comparative Proteomic Analysis ◽  
Hepatic Fat ◽  
Tea Extract

An overview of deregulated lipid metabolism in nonalcoholic fatty liver disease with special focus on lysosomal acid lipase

2020 ◽  
Vol 319 (4) ◽  
pp. G469-G480
Author(s):  
Simone Carotti ◽  
Katia Aquilano ◽  
Francesco Valentini ◽  
Sergio Ruggiero ◽  
Francesca Alletto ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Fat Metabolism ◽  
Special Focus ◽  
Acid Lipase ◽  
Nonalcoholic Fatty Liver ◽  
Lysosomal Acid ◽  
Hepatic Fat

Obesity and type 2 diabetes are frequently complicated by excess fat accumulation in the liver, which is known as nonalcoholic fatty liver disease (NAFLD). In this context, liver steatosis develops as a result of the deregulation of pathways controlling de novo lipogenesis and fat catabolism. Recent evidences suggest the clinical relevance of a reduction in the activity of lysosomal acid lipase (LAL), which is a key enzyme for intracellular fat disposal, in patients with NAFLD. In this review, we provided a comprehensive overview of the critical steps in hepatic fat metabolism and alterations in these pathways in NAFLD, with a special focus on lipophagy and LAL activity. During NAFLD, hepatic fat metabolism is impaired at several levels, which is significantly contributed to by impaired lipophagy, in which reduced LAL activity may play an important role. For further research and intervention in NAFLD, targeting LAL activity may provide interesting perspectives.

scholarly journals Quantification of Hepatic Fat Fraction in Patients With Nonalcoholic Fatty Liver Disease

2020 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Qinhe Zhang ◽  
Ying Zhao ◽  
Jingjun Wu ◽  
Luhan Xie ◽  
Anliang Chen ◽  
...  
Keyword(s):  
Liver Disease ◽  
Fatty Liver ◽  
Nonalcoholic Fatty Liver Disease ◽  
Fatty Liver Disease ◽  
Nonalcoholic Fatty Liver ◽  
Hepatic Fat ◽  
Fat Fraction
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