scholarly journals Herb-drug interaction in the protective effect of Alpinia officinarum against gastric injury induced by indomethacin based on pharmacokinetic, tissue distribution and excretion studies in rats

2020 ◽  
Author(s):  
Xuguang Zhang ◽  
Zhenrui Xie ◽  
Xun Chen ◽  
Junqiang Qiu ◽  
Yinfeng Tan ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Protective Effect ◽  
Tissue Distribution ◽  
Gastric Injury ◽  
Alpinia Officinarum

Sunitinib-ibuprofen drug interaction affects the pharmacokinetics and tissue distribution of sunitinib to brain, liver, and kidney in male and female mice differently

2015 ◽  
Vol 29 (4) ◽  
pp. 404-416 ◽  
Author(s):  
Christine Li Ling Lau ◽  
Sook Tyng Chan ◽  
Manimegahlai Selvaratanam ◽  
Hui Wen Khoo ◽  
Adeline Yi Ling Lim ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Tissue Distribution ◽  
Male And Female ◽  
Female Mice ◽  
Liver And Kidney

Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

2012 ◽  
Vol 142 (2) ◽  
pp. 346-353 ◽  
Author(s):  
Mee-Young Lee ◽  
In-Sik Shin ◽  
Woo-Young Jeon ◽  
Chang-Seob Seo ◽  
Hyekyung Ha ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury ◽  
Herbal Formula

scholarly journals Protective effect by anti-spasmodic activity of tiquizium bromide on NSAIDs-induced gastric injury in rats.

1999 ◽  
Vol 79 ◽  
pp. 207
Author(s):  
Hirotaka Tokunaga ◽  
Toshie Yamauchi ◽  
Fujie Mizutani ◽  
Takaharu Saito ◽  
Yuji Iwanaga ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury

scholarly journals Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury

2011 ◽  
Vol 57 (3) ◽  
pp. 289-292 ◽  
Author(s):  
Mijeong Kim ◽  
In Young Hwang ◽  
Je-Hyuk Lee ◽  
Kun Ho Son ◽  
Choon-Sik Jeong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ethanol Extract ◽  
Gastric Injury

Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice

2017 ◽  
Vol 35 (4) ◽  
pp. 399-411 ◽  
Author(s):  
Chii Chii Chew ◽  
Salby Ng ◽  
Yun Lee Chee ◽  
Teng Wai Koo ◽  
Ming Hui Liew ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Tissue Distribution ◽  
Male And Female ◽  
Female Mice ◽  
Drug Drug Interaction

Diurnal Variation in the Protective Effect of Melatonin Against Gastric Injury Caused by Ischemia-Reperfusion

2002 ◽  
Vol 33 (3) ◽  
pp. 319-332 ◽  
Author(s):  
Juan Cabeza ◽  
Catalina Alarcón de la Lastra ◽  
Maria José Martín ◽  
Juán Manuel Herrerias ◽  
Virginia Motilva
Keyword(s):  
Protective Effect ◽  
Diurnal Variation ◽  
Ischemia Reperfusion ◽  
Gastric Injury

Protective effect of melatonin on indomethacin-induced gastric injury in rats

1999 ◽  
Vol 26 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Catalina Alarcón Lastra ◽  
Virginia Motllva ◽  
Maria José Martin ◽  
Ana Nieto ◽  
María Dolores Barranco ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury

scholarly journals Effect of Water Extract of Mangosteen Pericarp on Donepezil Pharmacokinetics in Mice

Molecules ◽  
2021 ◽  
Vol 26 (17) ◽  
pp. 5246
Author(s):  
Mingoo Bae ◽  
Seung Yon Han ◽  
Eun-Sun Kim ◽  
Byung Hoon You ◽  
Young-Mi Kim ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Tissue Distribution ◽  
Neuroblastoma Cells ◽  
Water Extract ◽  
Systemic Exposure ◽  
Inhibitory Effect ◽  
Target Tissue ◽  
Herbal Products ◽  
The Brain ◽  
Memory Enhancing

The pharmacokinetic (PK) change in a drug by co-administered herbal products can alter the efficacy and toxicity. In the circumstances that herb–drug combinations have been increasingly attempted to alleviate Alzheimer’s disease (AD), the PK evaluation of herb–drug interaction (HDI) is necessary. The change in systemic exposure as well as target tissue distribution of the drug have been issued in HDIs. Recently, the memory-enhancing effects of water extract of mangosteen pericarp (WMP) has been reported, suggesting a potential for the combination of WMP and donepezil (DNP) for AD treatment. Thus, it was evaluated how WMP affects the PK change of donepezil, including systemic exposure and tissue distribution in mice after simultaneous oral administration of DNP with WMP. Firstly, co-treatment of WMP and donepezil showed a stronger inhibitory effect (by 23.0%) on the neurotoxicity induced by Aβ(25–35) in SH-SY5Y neuroblastoma cells than donepezil alone, suggesting that the combination of WMP and donepezil may be more effective in moderating neurotoxicity than donepezil alone. In PK interaction, WMP increased donepezil concentration in the brain at 4 h (by 63.6%) after administration without affecting systemic exposure of donepezil. Taken together, our results suggest that WMP might be used in combination with DNP as a therapy for AD.

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