scholarly journals Increased expression of tight junction protein�occludin is associated with the protective effect of mosapride against aspirin‑induced gastric injury

2017 ◽  
Author(s):  
Chenchen Liu ◽  
Zhaotao Duan ◽  
Yue Guan ◽  
Hailu Wu ◽  
Kewei Hu ◽  
...  
Keyword(s):  
Tight Junction ◽  
Protective Effect ◽  
Gastric Injury

Protective effect of Bojungikki-tang, a traditional herbal formula, against alcohol-induced gastric injury in rats

2012 ◽  
Vol 142 (2) ◽  
pp. 346-353 ◽  
Author(s):  
Mee-Young Lee ◽  
In-Sik Shin ◽  
Woo-Young Jeon ◽  
Chang-Seob Seo ◽  
Hyekyung Ha ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury ◽  
Herbal Formula

scholarly journals Protective effect by anti-spasmodic activity of tiquizium bromide on NSAIDs-induced gastric injury in rats.

1999 ◽  
Vol 79 ◽  
pp. 207
Author(s):  
Hirotaka Tokunaga ◽  
Toshie Yamauchi ◽  
Fujie Mizutani ◽  
Takaharu Saito ◽  
Yuji Iwanaga ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury

scholarly journals Protective Effect of Cimicifuga heracleifolia Ethanol Extract and Its Constituents against Gastric Injury

2011 ◽  
Vol 57 (3) ◽  
pp. 289-292 ◽  
Author(s):  
Mijeong Kim ◽  
In Young Hwang ◽  
Je-Hyuk Lee ◽  
Kun Ho Son ◽  
Choon-Sik Jeong ◽  
...  
Keyword(s):  
Protective Effect ◽  
Ethanol Extract ◽  
Gastric Injury

Diurnal Variation in the Protective Effect of Melatonin Against Gastric Injury Caused by Ischemia-Reperfusion

2002 ◽  
Vol 33 (3) ◽  
pp. 319-332 ◽  
Author(s):  
Juan Cabeza ◽  
Catalina Alarcón de la Lastra ◽  
Maria José Martín ◽  
Juán Manuel Herrerias ◽  
Virginia Motilva
Keyword(s):  
Protective Effect ◽  
Diurnal Variation ◽  
Ischemia Reperfusion ◽  
Gastric Injury

Protective effect of melatonin on indomethacin-induced gastric injury in rats

1999 ◽  
Vol 26 (2) ◽  
pp. 101-107 ◽  
Author(s):  
Catalina Alarcón Lastra ◽  
Virginia Motllva ◽  
Maria José Martin ◽  
Ana Nieto ◽  
María Dolores Barranco ◽  
...  
Keyword(s):  
Protective Effect ◽  
Gastric Injury

scholarly journals Lack of biochemical correlation between the protective effect of prostaglandins and nitric oxide pathway on NSAID-induced gastric injury

1998 ◽  
Vol 114 ◽  
pp. A115
Author(s):  
J. Esteban ◽  
J.M. Herrerías ◽  
M.M. Espinosa ◽  
J.A. Martín ◽  
M.A. Rodríguez ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Protective Effect ◽  
Gastric Injury ◽  
Nitric Oxide Pathway

scholarly journals Protective Effects of SIRT6 Overexpression against DSS-Induced Colitis in Mice

Cells ◽  
2020 ◽  
Vol 9 (6) ◽  
pp. 1513 ◽  
Author(s):  
Kang Xu ◽  
Yannan Guo ◽  
Lu Ping ◽  
Ying Qiu ◽  
Qingfei Liu ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Tight Junction ◽  
Protective Effect ◽  
Therapeutic Target ◽  
Intestinal Epithelial Cells ◽  
Clinical Manifestations ◽  
Protective Effects ◽  
Intestinal Epithelial

Sirtuin 6 (SIRT6), as a NAD + -dependent deacetylase, plays an indispensable role in the regulation of health and physiology. Loss of SIRT6 causes spontaneous colitis in mice and makes intestinal epithelial cells prone to stress. However, whether SIRT6 overexpression increases resistance to colitis remains unknown. Here, in vivo results demonstrated that SIRT6 overexpression attenuates DSS-induced colitis in terms of clinical manifestations, histopathological damage, loss of tight junction function and imbalanced intestinal microenvironment. Additionally, we also found that the activation of NF-κB and c-Jun induced by DSS is diminished by SIRT6 overexpression. Furthermore, SIRT6 may regulate TAK1 to inhibit NF-κB and c-Jun signaling. Thus, our findings highlight the protective effect of SIRT6 on colon, further supporting the perspective that SIRT6 may be a therapeutic target for intestine injury under stress.

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