Sunitinib-ibuprofen drug interaction affects the pharmacokinetics and tissue distribution of sunitinib to brain, liver, and kidney in male and female mice differently

2015 ◽  
Vol 29 (4) ◽  
pp. 404-416 ◽  
Author(s):  
Christine Li Ling Lau ◽  
Sook Tyng Chan ◽  
Manimegahlai Selvaratanam ◽  
Hui Wen Khoo ◽  
Adeline Yi Ling Lim ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Tissue Distribution ◽  
Male And Female ◽  
Female Mice ◽  
Liver And Kidney

Diclofenac sex-divergent drug-drug interaction with Sunitinib: pharmacokinetics and tissue distribution in male and female mice

2017 ◽  
Vol 35 (4) ◽  
pp. 399-411 ◽  
Author(s):  
Chii Chii Chew ◽  
Salby Ng ◽  
Yun Lee Chee ◽  
Teng Wai Koo ◽  
Ming Hui Liew ◽  
...  
Keyword(s):  
Drug Interaction ◽  
Tissue Distribution ◽  
Male And Female ◽  
Female Mice ◽  
Drug Drug Interaction

scholarly journals SUB-ACUTE ORAL TOXICITY PROFILING OF THE METHANOLIC LEAF EXTRACT OF CLINACANTHUS NUTANS IN MALE AND FEMALE ICR MICE

2018 ◽  
Vol 10 (12) ◽  
pp. 25
Author(s):  
Samiaa Jamil Abdulwahid ◽  
Meng Yong Goh ◽  
Mahdi Ebrahimi ◽  
Norhafizah Mohtarrudin ◽  
Zailina Binti Hashim
Keyword(s):  
Body Weight ◽  
Blood Cell ◽  
Leaf Extract ◽  
Distilled Water ◽  
Acute Oral Toxicity ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Liver And Kidney ◽  
Clinacanthus Nutans

Objective: This study aims to investigate the sub-acute oral toxicity of a methanolic leaf extract of Clinacanthus nutans (MECN) in male and female mice.Methods: The study used three groups of male and female mice, the crude MECN was dissolved in distilled water and administered orally in single doses of 1000 and 2000 mg/kg body weight for 28 d by gavage, at a dosing volume of 10 ml/kg body weight, while the control group received only the distilled water. Mice were weighed weekly for the duration of the study period. After the treatment period, the blood samples were collected and examined for hematology changes, total red blood cell (RBC) and total white blood cell (WBC), packed cell volume (PCV) and plasma protein concentration. The serum was analyzed for liver and kidney function test. The degree of injury of the liver and kidney tissue was histopathologically assessed and scored under the light microscopy. one-way analysis of variance (ANOVA) with Turkey’s test was used to analyze the difference (p<0.05) of means across treatment groups.Results: There were no significant (p>0.05) changes in the body weight, hematological, biochemical and histology signs of toxicity for both male and female mice, except for the sodium level which was decreased in the mice treated with 2000 mg/kg of MECN (137±5.06) as compared to the 1000 (151±1.91) mg/kg as well as the control males (152±3.74) [F=4.87, p=0.03].Conclusion: This study showed that MECN at dosages up to 2000 mg/kg is safe to be used in mice regardless of their sex. Overall, this study suggests the potential utility of MECN in the development of herbal drug formulations in vivo.

scholarly journals BIOCHEMICAL AND PATHOLOGICAL ASSESSMENT OF RICINUS COMMUNIS LEAF EXTRACT ADMINISTRATION ON LIVER AND KIDNEY IN MICE

2019 ◽  
Vol 3 (4) ◽  
Author(s):  
Haile Gebeslassie ◽  
Peter Etim Ekanem ◽  
Mebrahtom Gebrelibanos ◽  
Hafte Assefa ◽  
Tefera Belsty ◽  
...  
Keyword(s):  
Ricinus Communis ◽  
Tween 80 ◽  
Serum Levels ◽  
Acute Administration ◽  
Weight Changes ◽  
Male And Female ◽  
Female Mice ◽  
Methanolic Extracts ◽  
Group I ◽  
Liver And Kidney

Background: Medicinal plants remain the mainstay for primary healthcare. The present study evaluated the effects of sub-acute administration of Ricinus communis fresh leaves’ methanolic extract on the histopathology and biochemistry of the liver and kidney in Swiss albino mice. Methods: 24 male and female mice were randomly assigned into four equal groups. Group I (control) received 5% tween 80 orally, while the treated groups; II, III and IV received oral Ricinus communis extract at 250mg/kg/day, 500mg/kg/day, and 1000 mg/kg/day for 28 consecutive days, respectively. Tissue processing, staining and biochemical analysis were used to assess the changes induced histopathologically and biochemically on the liver and kidney tissues. Results: Female treated mice showed significant weight changes while male treated mice showed no changes. Histopathological alterations in liver and kidney sections were observed both in male and female mice. Serum levels of alanine aminotransferase, alkaline phosphatase and aspartate aminotransferase showed significant changes in both sexes. There were no significant changes in serum creatinine at all doses and in both sexes Conclusion: Methanolic extracts of Ricinus communis fresh leaves had hepatotoxic and nephrotoxic effects. Key words: Histopathology; Ricinus communis; liver; kidney; biochemical

A subchronic oral toxicity study on medical herb extract, KIOM CRC#BP10A, in male and female mice

Planta Medica ◽  
2015 ◽  
Vol 81 (16) ◽  
Author(s):  
ES Cho ◽  
YJ Lee ◽  
JS Park ◽  
J Kim ◽  
NS Kim ◽  
...  
Keyword(s):  
Toxicity Study ◽  
Oral Toxicity ◽  
Male And Female ◽  
Female Mice ◽  
Subchronic Oral Toxicity Study ◽  
Herb Extract

Early Life Exposure to Antibiotic Alters Energy Balance during Chronic High-Fat Feeding in Adult Male and Female Mice

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 1999-P ◽  
Author(s):  
HYE LIM NOH ◽  
SUJIN SUK ◽  
RANDALL H. FRIEDLINE ◽  
KUNIKAZU INASHIMA ◽  
DUY A. TRAN ◽  
...  
Keyword(s):  
Energy Balance ◽  
Adult Male ◽  
Early Life ◽  
High Fat ◽  
Male And Female ◽  
Female Mice ◽  
Early Life Exposure ◽  
Fat Feeding

Comparison of Antinociceptive Effects Induced by Kappa Opioid Agonists in Male and Female Mice

Analgesia ◽  
1999 ◽  
Vol 4 (3) ◽  
pp. 397-404 ◽  
Author(s):  
Corinne A. Patrick ◽  
M. C. Holden Ko ◽  
James H. Woods
Keyword(s):  
Kappa Opioid ◽  
Male And Female ◽  
Female Mice ◽  
Opioid Agonists ◽  
Antinociceptive Effects

Maternal separation affects the electrophysiological properties of Aδ‐fibres and nociceptive behaviours in male and female mice

2020 ◽  
Vol 80 (6) ◽  
pp. 538-546
Author(s):  
Nancy Paniagua ◽  
Rocío Girón ◽  
Carlos Goicoechea ◽  
Mª Isabel Martín‐Fontelles ◽  
Ana Bagues
Keyword(s):  
Maternal Separation ◽  
Male And Female ◽  
Electrophysiological Properties ◽  
Female Mice

scholarly journals Digging behavior discrimination test to probe burrowing and exploratory digging in male and female mice

2021 ◽  
Author(s):  
Heather L. Pond ◽  
Abigail T. Heller ◽  
Brian M. Gural ◽  
Olivia P. McKissick ◽  
Molly K. Wilkinson ◽  
...  
Keyword(s):  
Discrimination Test ◽  
Male And Female ◽  
Female Mice ◽  
Digging Behavior
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