scholarly journals New approaches to identification and characterization of tioconazole in raw material and in pharmaceutical dosage forms

2019 ◽  
Vol 9 (1) ◽  
pp. 40-48 ◽  
Author(s):  
Natalia L. Calvo ◽  
Vera A. Alvarez ◽  
María C. Lamas ◽  
Darío Leonardi
Keyword(s):  
Dosage Forms ◽  
Raw Material ◽  
Pharmaceutical Dosage Forms ◽  
New Approaches ◽  
Identification And Characterization

Identification and characterization of degradation products of dicloxacillin in bulk drug and pharmaceutical dosage forms

2007 ◽  
Vol 43 (4) ◽  
pp. 1470-1475 ◽  
Author(s):  
T. Joseph Sunder Raj ◽  
C.H. Bharati ◽  
K. Ranga Rao ◽  
P. Satyanarayana Rao ◽  
G.K.A.S.S. Narayan ◽  
...  
Keyword(s):  
Degradation Products ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Bulk Drug ◽  
Identification And Characterization

Thermal Characterization of Polymeric Coatings for Pharmaceutical Dosage Forms

2015 ◽  
Vol 352 (1) ◽  
pp. 59-65
Author(s):  
Adriana Fuliaş ◽  
Gabriela Vlase ◽  
Anamaria Todea ◽  
Titus Vlase ◽  
Ionuţ Ledeţi
Keyword(s):  
Thermal Characterization ◽  
Dosage Forms ◽  
Polymeric Coatings ◽  
Pharmaceutical Dosage Forms

A Comparative Chemometric Study for Quantitative Determination of Duloxetine Hydrochloride in the Presence of its Toxic Impurity 1-Naphthol

2020 ◽  
Vol 16 (8) ◽  
pp. 1030-1036 ◽  
Author(s):  
Basma H. Anwar ◽  
Nessreen S. Abdelhamid ◽  
Maimana A. Magdy ◽  
Ibrahim A. Naguib
Keyword(s):  
Least Squares ◽  
Multivariate Calibration ◽  
Dosage Forms ◽  
Hplc Method ◽  
Raw Material ◽  
Support Vector ◽  
Pharmaceutical Dosage Forms ◽  
Advantages And Disadvantages ◽  
Duloxetine Hydrochloride ◽  
Significant Difference

Background: Duloxetine hydrochloride (DUL) is a serotonin-norepinephrine reuptake inhibitor. It is used for treating depression and anxiety. It is available in the market as a capsule called Cymbatex®, which is used for the treatment of depression. 1-naphthol is a potential impurity of DUL. It is hepatotoxic to humans and has potential toxicity to freshwater fish. Objective: Duloxetine hydrochloride was determined in the presence of its toxic impurity 1-naphthol in raw material and in pharmaceutical dosage forms using three multivariate calibration chemometric methods. Methods: Classical Least Squares (CLS), Partial Least-Squares (PLS) and linear support vector regression (SVR) were developed using UV spectral data. The three methods were compared among each other and the advantages and disadvantages were discussed. For good results, a two-factor four-level experimental design was used, resulting in a training set of 16 mixtures containing different ratios of each component. The test set consisting of nine mixtures was necessary to test the ability of the proposed methods to predict DUL in the presence of its impurity, 1-naphthol. Results: The results show the success of the three developed methods to determine DUL in the presence of small levels of its toxic impurity with good accuracy and selectivity. The results of the dosage form were compared statistically to that of the reported HPLC method, with no significant difference in accuracy and precision. Conclusion: The suggested calibration models are suitable for routine analysis of the drug in bulk and pharmaceutical dosage forms. Compared to the CLS and PLS models, the SVR model gives the best results regarding the accuracy with a lower prediction error and better generalization ability. However, the CLS and PLS models are found to be simpler and faster in usage and management.

scholarly journals Identification and Characterization of Key Chemical Constituents in Processed Gastrodia elata Using UHPLC-MS/MS and Chemometric Methods

2019 ◽  
Vol 2019 ◽  
pp. 1-10
Author(s):  
Xide Ye ◽  
Yanhong Wang ◽  
Jianping Zhao ◽  
Mei Wang ◽  
Bharathi Avula ◽  
...  
Keyword(s):  
Chemical Constituents ◽  
Raw Material ◽  
Gastrodia Elata ◽  
Peak Areas ◽  
Marker Compounds ◽  
Fragmentation Patterns ◽  
Traditional Processing ◽  
Identification And Characterization ◽  
Processing Mechanism

Gastrodia elata Blume belongs to the Orchidaceae family. G. elata is often processed when used in traditional Chinese medicine (TCM). In the current study, a traditional processing method, known as “Jianchang Bang,” was applied. Steamed and dried (S&D) G. elata was processed with ginger juice for up to 5 days (GEP5D). An UHPLC-MS/MS combined with a chemometric method was developed for the analysis of processed G. elata along with the raw material as well as steamed and dried G. elata. As a result, the primary marker compounds were identified with the aid of TOF-MS and MS/MS analyses. Compared with the raw material of G. elata with GEP5D, three new parishin-type compounds were identified according to their retention time, accurate mass, and fragmentation patterns. The chromatographic peak areas for marker compounds, including S-(gastrodin)-glutathione, S-(4-hydroxybenzylamine)-glutathione, and parishin-type compounds, changed significantly. This result indicated that by applying the “Jianchang Bang” method, changes in chemical composition in G. elata contents were observed. The study also demonstrated that chemometric analysis is helpful in understanding the processing mechanism and will provide scientific support for the clinical application of G. elata.

scholarly journals DEM based investigation of powder packing in 3D printing of pharmaceutical tablets

2021 ◽  
Vol 249 ◽  
pp. 14012
Author(s):  
Koyel Sen ◽  
Tanu Mehta ◽  
Anson W.K.Ma ◽  
Bodhisattwa Chaudhuri
Keyword(s):  
3D Printing ◽  
Particle Density ◽  
Numerical Models ◽  
Dosage Forms ◽  
Raw Material ◽  
Pharmaceutical Dosage Forms ◽  
Printing Process ◽  
Powder Bed ◽  
Pharmaceutical Tablets ◽  
Powder Packing

3D printing is emerging as one of the most promising methods to manufacture Pharmaceutical dosage forms as it offers multiple advantages such as personalization of dosage forms, polypill, fabrication of complex dosage forms etc. 3D printing came into existence in 1980s but its use was extended recently to pharmaceutical industry along with the approval of first 3D printed tablet Spritam by FDA in 2015. Spritam was manufactured by Aprecia pharmaceuticals using binder jetting technology. Binder jet 3D printing involves a hopper for powder discharge and printheads for ink jetting. The properties of tablets are highly dependent upon the discharge quality of powder mixture from the hopper and jetting of the ink/binder solution from the printhead nozzle. In this study, numerical models were developed using Discrete element method (DEM) to gain better understanding of the binder jet 3D printing process. The DEM modeling of hopper discharge was performed using in-house DEM code to study the effect of raw material attributes such as powder bed packing density (i.e. particle size, particle density etc) on the printing process, especially during powder bed preparation. This DEM model was further validated experimentally, and the model demonstrated good agreement with experimental results.

scholarly journals Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3023
Author(s):  
Rishabha Malviya ◽  
Sonali Sundram ◽  
Shivkanya Fuloria ◽  
Vetriselvan Subramaniyan ◽  
Kathiresan V. Sathasivam ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Dosage Forms ◽  
Exothermic Peak ◽  
Water Soluble ◽  
Angle Of Repose ◽  
Pharmaceutical Dosage Forms ◽  
Hausner Ratio ◽  
Crystalline Nature ◽  
Phytochemical Constituents

Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

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