scholarly journals Evaluation and Characterization of Tamarind Gum Polysaccharide: The Biopolymer

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3023
Author(s):  
Rishabha Malviya ◽  
Sonali Sundram ◽  
Shivkanya Fuloria ◽  
Vetriselvan Subramaniyan ◽  
Kathiresan V. Sathasivam ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Dosage Forms ◽  
Exothermic Peak ◽  
Water Soluble ◽  
Angle Of Repose ◽  
Pharmaceutical Dosage Forms ◽  
Hausner Ratio ◽  
Crystalline Nature ◽  
Phytochemical Constituents

Polymers from natural sources are widely used as excipients in the formulation of pharmaceutical dosage forms. The objective of this study was to extract and further characterize the tamarind gum polysaccharide (TGP) obtained from Tamarindus indica as an excipient for biomedical applications. Double distilled water was used as a solvent for the extraction of gum while Ethyl alcohol was used as an antisolvent for the precipitation. The results of the Hausner ratio, Carr’s index and angle of repose were found to be 0.94, 6.25, and 0.14, respectively, which revealed that the powder is free-flowing with good flowability. The gum was investigated for purity by carrying out chemical tests for different phytochemical constituents and only carbohydrates were found to be present. The swelling index was found to be 87 ± 1%, which shows that TGP has good water intake capacity. The pH of the 1% gum solution was found to be neutral, approximately 6.70 ± 0.01. The ash values such as total ash, sulphated ash, acid insoluble ash, and water-soluble ash were found to be 14.00 ± 1.00%, 13.00 ± 0.05%, 14.04 ± 0.57% and 7.29 ± 0.06%, respectively. The IR spectra confirmed the presence of alcohol, amines, ketones, anhydrides groups. The contact angle was <90°, indicating favorable wetting and good spreading of liquid over the surface The scanning electron micrograph (SEM) revealed that the particle is spherical in shape and irregular. DSC analysis shows a sharp exothermic peak at 350 °C that shows its crystalline nature. The results of the evaluated properties showed that TGP has acceptable properties and can be used as a excipient to formulate dosage forms for biomedical applications.

Thermal Characterization of Polymeric Coatings for Pharmaceutical Dosage Forms

2015 ◽  
Vol 352 (1) ◽  
pp. 59-65
Author(s):  
Adriana Fuliaş ◽  
Gabriela Vlase ◽  
Anamaria Todea ◽  
Titus Vlase ◽  
Ionuţ Ledeţi
Keyword(s):  
Thermal Characterization ◽  
Dosage Forms ◽  
Polymeric Coatings ◽  
Pharmaceutical Dosage Forms

Identification and characterization of degradation products of dicloxacillin in bulk drug and pharmaceutical dosage forms

2007 ◽  
Vol 43 (4) ◽  
pp. 1470-1475 ◽  
Author(s):  
T. Joseph Sunder Raj ◽  
C.H. Bharati ◽  
K. Ranga Rao ◽  
P. Satyanarayana Rao ◽  
G.K.A.S.S. Narayan ◽  
...  
Keyword(s):  
Degradation Products ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms ◽  
Bulk Drug ◽  
Identification And Characterization

Characterization of Hazelnut Milk Powders: A Comparison of Spray-Drying and Freeze-Drying

2018 ◽  
Vol 14 (11-12) ◽  
Author(s):  
Ertan Ermis ◽  
Kübra Özkan Güner ◽  
Mustafa Tahsin Yilmaz
Keyword(s):  
Spray Drying ◽  
Freeze Drying ◽  
Milk Powder ◽  
Angle Of Repose ◽  
Drying Process ◽  
Residual Moisture ◽  
Hausner Ratio ◽  
Powder Samples ◽  
Supporting Material

Abstract Production of hazelnut milk powder (HMP) was investigated using maltodextrin (MD) as supporting material. Spray-drying and freeze-drying techniques were used to obtain the powder material. MD was added at concentrations of 5%, 10% and 15% (w/w) prior to drying. The powder properties were evaluated by determining flowing properties (Hausner ratio and angle of repose), thermal behaviour using DSC, molecular properties using FTIR, solubility and zeta potential. Hausner Ratio for both spray dried (SDHMP) and freze-dried (FDHMP) samples varied from 1.30 to 1.64 corresponding to very poor flow. The FDHM powder samples exhibited slightly lower Hausner Ratio values than SDHM powders. FTIR spectras showed that both SDHM and FDHM exhibited similar absorbance characteristics with slight differences. Lower endothermic transition temperatures were recorded from FDHMP when compared to SDHMP. The solubility in water for both powder samples ranged from 20 to 65 % depending on the drying method and MD content. Based on the residual moisture content, water activity, solubility and flowability, spray drying process was found to produce better quality powders compared to freeze drying process.

scholarly journals HOT MELT EXTRUSION IN ENGINEERING OF DRUG COCRYSTALS: A REVIEW

2021 ◽  
pp. 10-19
Author(s):  
ARCHANA RAJADHYAX ◽  
UJWALA SHINDE ◽  
HARITA DESAI ◽  
SHRUSHTI MANE
Keyword(s):  
Crystal Engineering ◽  
Process Analytical Technology ◽  
Hot Melt Extrusion ◽  
Dosage Forms ◽  
Solvent Free ◽  
Water Soluble ◽  
Melt Extrusion ◽  
Pharmaceutical Dosage Forms ◽  
Free Process ◽  
Hot Melt

Crystal engineering technique has been widely explored in recent times to bring about changes in crystallinity which aids to achieve various goals such as solubility enhancement, stability and in vivo bioavailability without altering the chemical properties of the drug. Cocrystallisation is one of the crystal engineering approaches where the drug and an inert coformer are linked together by hydrogen bonding forming supramolecular homosynthon or heterosynthon using solvent-based or solvent-free techniques. Processing of active pharmaceutical ingredients with inert water-soluble coformers yields multicomponent crystalline cocrystals with high-performance characteristics and enhanced flow properties. Due to the emerging need of the industry for greener techniques, hot melt extrusion (HME), a continuous and solvent-free process is emerging as a field of interest in the mechanochemical synthesis of various pharmaceutical dosage forms such as solid dispersions, implants, ointments, and cocrystals. The current review emphasizes the role of HME as a cocrystallization technique for drugs to tailor-make their properties and ease of formulation. The distinct feature of HME is phase control during the process of cocrystallization. Furthermore, the selection of appropriate coformers with desirable water-solubility and stability features makes HME amenable to cocrystallization of versatile actives yielding suitable dosage forms. The application of process analytical technology further adds ease of monitoring during HME in cocrystallization approaches. Due to these salient features of HME, it can act as a prospective technique for cocrystallization of versatile drugs thus yielding dosage forms with desirable solubility and stability features.

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