scholarly journals Development and validation of a simple and robust HPLC method with UV detection for quantification of the hepatitis C virus inhibitor daclatasvir in human plasma

2017 ◽  
Vol 134 ◽  
pp. 275-281 ◽  
Author(s):  
Giulio Nannetti ◽  
Lorenzo Messa ◽  
Marta Celegato ◽  
Silvana Pagni ◽  
Monica Basso ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Plasma ◽  
Hplc Method ◽  
Uv Detection ◽  
Virus Inhibitor ◽  
Development And Validation

scholarly journals Stress stability study of simeprevir, a hepatitis C virus inhibitor, using feasible TLC-spectro-densitometry: application to pharmaceutical dosage form and human plasma

RSC Advances ◽  
2020 ◽  
Vol 10 (36) ◽  
pp. 21100-21107 ◽  
Author(s):  
Bassam Shaaban Mohammed ◽  
Amal E. Hamad ◽  
Sayed M. Derayea
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Plasma ◽  
Dosage Form ◽  
Direct Action ◽  
Stability Study ◽  
Pharmaceutical Dosage Form ◽  
Virus Inhibitor

Simeprevir is one of the newest direct action anti-hepatitis C drugs.

Development and validation of a highly sensitive second derivative synchronous fluorescence spectroscopic method for the simultaneous determination of elbasvir and grazoprevir in pharmaceutical preparation and human plasma

2020 ◽  
Vol 44 (43) ◽  
pp. 18679-18685
Author(s):  
Khalid A. M. Attia ◽  
Ahmed El-Olemy ◽  
Sherif Ramzy ◽  
Ahmed H. Abdelazim ◽  
Mohamed A. Hasan ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Simultaneous Determination ◽  
Human Plasma ◽  
Pharmaceutical Preparation ◽  
Spectroscopic Method ◽  
Second Derivative ◽  
Highly Sensitive ◽  
Development And Validation

Elbasvir and grazoprevir combination has been newly approved for the treatment of patients infected with hepatitis C virus.

scholarly journals Development of a simple HPLC–UV method for the determination of the hepatitis C virus inhibitor simeprevir in human plasma

2016 ◽  
Vol 121 ◽  
pp. 197-203 ◽  
Author(s):  
Giulio Nannetti ◽  
Silvana Pagni ◽  
Saverio G. Parisi ◽  
Alfredo Alberti ◽  
Arianna Loregian ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Plasma ◽  
Virus Inhibitor

scholarly journals Method Development and Validation for Determination of Febuxostat from Spiked Human Plasma Using RP-HPLC with UV Detection

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Monita Gide ◽  
Pankaj Sharma ◽  
Ravindra Saudagar ◽  
Birendra Shrivastava
Keyword(s):  
Human Plasma ◽  
High Performance ◽  
Method Development ◽  
Internal Standard ◽  
Hplc Method ◽  
Uv Detection ◽  
Least Square ◽  
Spiked Human Plasma ◽  
Rp Hplc ◽  
Development And Validation

A rapid, simple, selective, and specific reverse phase high performance liquid chromatography (RP-HPLC) method with UV detection (315 nm) was developed and validated for estimation of febuxostat from spiked human plasma. The analyte and internal standard (diclofenac) were extracted using LLE with diethyl ether. The chromatographic separation was performed on Shodex C-18-4E (5 μm; 250×4.6 mm) with a mobile phase comprised of methanol : acetate buffer pH 4, 20 mM (90 : 10 v/v), at a flow rate of 1 mL/min. Febuxostat was well resolved from plasma constituents and internal standard. The calibration curve was linear in the range of 250–8000 ng/mL. The heteroscedasticity was minimized by using weighted least square regression with weighing factor of 1/x. The intraday and interday %RSD was less than 15. Results of recovery studies prove the extraction efficiency. Stability data indicated that febuxostat was stable in plasma after three freeze thaw cycles and upon storage at −20°C for 30 days.

On-chip purification and detection of hepatitis C virus RNA from human plasma

2016 ◽  
Vol 208 ◽  
pp. 54-61 ◽  
Author(s):  
V. Vaghi ◽  
C. Potrich ◽  
L. Pasquardini ◽  
L. Lunelli ◽  
L. Vanzetti ◽  
...  
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Plasma ◽  
Hepatitis C Virus Rna ◽  
Virus Rna ◽  
On Chip

scholarly journals Antibody against hepatitis C virus(HCV) in hemophiliacs and in human plasma preparation products.

1990 ◽  
Vol 36 (4) ◽  
pp. 524-527
Author(s):  
Susumu Okubo ◽  
Manabu Yamaoka ◽  
Keiko Okayama ◽  
Tomoko Ishida ◽  
Kojiro Yasunaga
Keyword(s):  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Human Plasma
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