Opioid mediation of endogenous pain modulation methods in healthy controls and patients with Temporomandibular Disorder

2012 ◽  
Vol 13 (4) ◽  
pp. S31
Author(s):  
C. King ◽  
J. Riley ◽  
R. Caudle ◽  
N. Gravenstein ◽  
R. Fillingim
Keyword(s):  
Temporomandibular Disorder ◽  
Pain Modulation ◽  
Healthy Controls ◽  
Endogenous Pain Modulation ◽  
Modulation Methods

S1814 Aberrant Connectivity of Brain Centers During Somatic Pain and Activation of Endogenous Pain Modulation in IBS Compared to Healthy Controls

2008 ◽  
Vol 134 (4) ◽  
pp. A-275
Author(s):  
Steven Graham ◽  
Clive H. Wilder-Smith ◽  
Guanghui Song ◽  
Khay Guan Yeoh ◽  
Khek Yu Ho
Keyword(s):  
Pain Modulation ◽  
Healthy Controls ◽  
Somatic Pain ◽  
Endogenous Pain Modulation

scholarly journals Serotonergic gene-to-gene interaction is associated with mood and GABA concentrations but not with pain-related cerebral processing in fibromyalgia subjects and healthy controls

2021 ◽  
Vol 14 (1) ◽  
Author(s):  
Isabel Ellerbrock ◽  
Angelica Sandström ◽  
Jeanette Tour ◽  
Silvia Fanton ◽  
Diana Kadetoff ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Gene Interaction ◽  
Pain Modulation ◽  
Anterior Cingulate ◽  
Healthy Controls ◽  
Inhibitory Effects ◽  
Affective Characteristics ◽  
Endogenous Pain Modulation ◽  
Rostral Anterior Cingulate Cortex ◽  
Cerebral Processing

AbstractThe neurotransmitter serotonin, involved in the regulation of pain and emotion, is critically regulated by the 5‐HT1A autoreceptor and the serotonin transporter (5-HTT). Polymorphisms of these genes affect mood and endogenous pain modulation, both demonstrated to be altered in fibromyalgia subjects (FMS). Here, we tested the effects of genetic variants of the 5‐HT1A receptor (CC/G-carriers) and 5-HTT (high/intermediate/low expression) on mood, pain sensitivity, cerebral processing of evoked pain (functional MRI) and concentrations of GABA and glutamate (MR spectroscopy) in rostral anterior cingulate cortex (rACC) and thalamus in FMS and healthy controls (HC). Interactions between serotonin-relevant genes were found in affective characteristics, with genetically inferred high serotonergic signalling (5-HT1A CC/5-HTThigh genotypes) being more favourable across groups. Additionally, 5‐HT1A CC homozygotes displayed higher pain thresholds than G-carriers in HC but not in FMS. Cerebral processing of evoked pressure pain differed between groups in thalamus with HC showing more deactivation than FMS, but was not influenced by serotonin-relevant genotypes. In thalamus, we observed a 5‐HT1A-by-5-HTT and group-by-5-HTT interaction in GABA concentrations, with the 5-HTT high expressing genotype differing between groups and 5‐HT1A genotypes. No significant effects were seen for glutamate or in rACC. To our knowledge, this is the first report of this serotonergic gene-to-gene interaction associated with mood, both among FMS (depression) and across groups (anxiety). Additionally, our findings provide evidence of an association between the serotonergic system and thalamic GABA concentrations, with individuals possessing genetically inferred high serotonergic signalling exhibiting the highest GABA concentrations, possibly enhancing GABAergic inhibitory effects via 5-HT.

scholarly journals Gene-to-gene interactions regulate endogenous pain modulation in fibromyalgia patients and healthy controls—antagonistic effects between opioid and serotonin-related genes

Pain ◽  
2017 ◽  
Vol 158 (7) ◽  
pp. 1194-1203 ◽  
Author(s):  
Jeanette Tour ◽  
Monika Löfgren ◽  
Kaisa Mannerkorpi ◽  
Björn Gerdle ◽  
Anette Larsson ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Gene Interactions ◽  
Healthy Controls ◽  
Antagonistic Effects ◽  
Endogenous Pain Modulation

scholarly journals Training volume is associated with pain sensitivity, but not with endogenous pain modulation, in competitive swimmers

2019 ◽  
Vol 37 ◽  
pp. 150-156 ◽  
Author(s):  
Kevin Kuppens ◽  
Stef Feijen ◽  
Nathalie Roussel ◽  
Jo Nijs ◽  
Patrick Cras ◽  
...  
Keyword(s):  
Pain Sensitivity ◽  
Pain Modulation ◽  
Training Volume ◽  
Endogenous Pain Modulation ◽  
Competitive Swimmers

Association Between Polymorphisms in Serotonin and Dopamine-Related Genes and Endogenous Pain Modulation

2011 ◽  
Vol 12 (8) ◽  
pp. 875-883 ◽  
Author(s):  
Roi Treister ◽  
Dorit Pud ◽  
Richard P. Ebstein ◽  
Efrat Laiba ◽  
Yael Raz ◽  
...  
Keyword(s):  
Pain Modulation ◽  
Endogenous Pain Modulation
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