scholarly journals Rational design of a new cytarabine-based prodrug for highly efficient oral delivery of cytarabine

RSC Advances ◽  
2018 ◽  
Vol 8 (24) ◽  
pp. 13103-13111 ◽  
Author(s):  
Jing Zhang ◽  
Di Zhang ◽  
Xu Hu ◽  
Ruiling Liu ◽  
Zhonghao Li ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Oral Delivery ◽  
Rational Design ◽  
Highly Efficient

To overcome the drawbacks of cytarabine such as bad liposolubility and low bioavailability, we rationally designed a new cytarabine-based prodrug for oral cytarabine delivery, realizing significantly enhanced bioavailability for cancer therapy.

Rational Design of Reversible Redox Shuttle for Highly Efficient Light-Driven Microswimmer

ACS Nano ◽  
2020 ◽  
Vol 14 (3) ◽  
pp. 3272-3280 ◽  
Author(s):  
Jizhuang Wang ◽  
Ze Xiong ◽  
Ming Liu ◽  
Xiao-meng Li ◽  
Jing Zheng ◽  
...  
Keyword(s):  
Rational Design ◽  
Highly Efficient ◽  
Reversible Redox ◽  
Redox Shuttle

Rational design of ionic V-MOF with confined Mo species for highly efficient oxidative desulfurization

2021 ◽  
pp. 120594
Author(s):  
Shuo Wang ◽  
Xu Zhang ◽  
Xue Chang ◽  
Meng-Ya Zong ◽  
Cun-Zheng Fan ◽  
...  
Keyword(s):  
Rational Design ◽  
Oxidative Desulfurization ◽  
Highly Efficient

scholarly journals In situ delivery of biobutyrate by probiotic Escherichia coli for cancer therapy

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Chung-Jen Chiang ◽  
Yan-Hong Hong
Keyword(s):  
Escherichia Coli ◽  
Cancer Therapy ◽  
Rational Design ◽  
Hypoxic Condition ◽  
Human Colorectal Cancer ◽  
Apoptosis Pathway ◽  
Mitochondrial Apoptosis Pathway ◽  
Cycle Arrest ◽  
Human Colorectal Cancer Cell

AbstractButyrate has a bioactive function to reduce carcinogenesis. To achieve targeted cancer therapy, this study developed bacterial cancer therapy (BCT) with butyrate as a payload. By metabolic engineering, Escherichia coli Nissle 1917 (EcN) was reprogrammed to synthesize butyrate (referred to as biobutyrate) and designated EcN-BUT. The adopted strategy includes construction of a synthetic pathway for biobutyrate and the rational design of central metabolism to increase the production of biobutyrate at the expense of acetate. With glucose, EcN-BUT produced primarily biobutyrate under the hypoxic condition. Furthermore, human colorectal cancer cell was administrated with the produced biobutyrate. It caused the cell cycle arrest at the G1 phase and induced the mitochondrial apoptosis pathway independent of p53. In the tumor-bearing mice, the injected EcN-BUT exhibited tumor-specific colonization and significantly reduced the tumor volume by 70%. Overall, this study opens a new avenue for BCT based on biobutyrate.

scholarly journals Self-assembled porphyrin polymer nanoparticles with NIR-II emission and highly efficient photothermal performance in cancer therapy

2022 ◽  
Vol 13 ◽  
pp. 100198
Author(s):  
Cheng Li ◽  
Zijin Luo ◽  
Lixia Yang ◽  
Jun Chen ◽  
Kai Cheng ◽  
...  
Keyword(s):  
Cancer Therapy ◽  
Polymer Nanoparticles ◽  
Highly Efficient ◽  
Self Assembled

Rational Design of Chelated Aluminum Complexes toward Highly Efficient and Thermally Stable Electron-Transporting Materials

2014 ◽  
Vol 26 (12) ◽  
pp. 3693-3700 ◽  
Author(s):  
Na Lin ◽  
Juan Qiao ◽  
Lian Duan ◽  
Jie Xue ◽  
Liduo Wang
Keyword(s):  
Rational Design ◽  
Thermally Stable ◽  
Highly Efficient ◽  
Aluminum Complexes
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