Disrupted interhemispheric resting-state functional connectivity and structural connectivity in first-episode, treatment-naïve generalized anxiety disorder

2019 ◽  
Vol 251 ◽  
pp. 280-286 ◽  
Author(s):  
Wei Wang ◽  
Zhaohui Peng ◽  
Xiang Wang ◽  
Peng Wang ◽  
Qingchu Li ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Structural Connectivity ◽  
First Episode ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity ◽  
Treatment Naïve

scholarly journals 1122 RESTING STATE FUNCTIONAL CONNECTIVITY IN PRIMARY INSOMNIA, GENERALIZED ANXIETY DISORDER AND CONTROLS

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A418-A418
Author(s):  
EF Pace-Schott ◽  
JP Zimmerman ◽  
RM Bottary ◽  
EG Lee ◽  
MR Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals Resting state functional connectivity in primary insomnia, generalized anxiety disorder and controls

2017 ◽  
Vol 265 ◽  
pp. 26-34 ◽  
Author(s):  
Edward F. Pace-Schott ◽  
Jared P. Zimmerman ◽  
Ryan M. Bottary ◽  
Erik G. Lee ◽  
Mohammed R. Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naïve Patients With Generalized Anxiety Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Mei Wang ◽  
Lingxiao Cao ◽  
Hailong Li ◽  
Hongqi Xiao ◽  
Yao Ma ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Trait Anxiety ◽  
Resting State ◽  
Superior Temporal Gyrus ◽  
Anterior Cingulate ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity ◽  
Drug Naïve ◽  
State And Trait Anxiety

Objective: Although previous studies have reported on disrupted amygdala subregional functional connectivity in generalized anxiety disorder (GAD), most of these studies were conducted in GAD patients with comorbidities or with drug treatment. Besides, whether/how the amygdala subregional functional networks were associated with state and trait anxiety is still largely unknown.Methods: Resting-state functional connectivity of amygdala subregions, including basolateral amygdala (BLA) and centromedial amygdala (CMA) as seed, were mapped and compared between 37 drug-naïve, non-comorbidity GAD patients and 31 age- and sex-matched healthy controls (HCs). Relationships between amygdala subregional network dysfunctions and state/trait anxiety were examined using partial correlation analyses.Results: Relative to HCs, GAD patients showed weaker functional connectivity of the left BLA with anterior cingulate/medial prefrontal cortices. Significantly increased functional connectivity of right BLA and CMA with superior temporal gyrus and insula were also identified in GAD patients. Furthermore, these functional connectivities showed correlations with state and trait anxiety scores.Conclusions: These findings revealed abnormal functional coupling of amygdala subregions in GAD patients with regions involved in fear processing and emotion regulation, including anterior cingulate/medial prefrontal cortex and superior temporal gyrus, which provide the unique biological markers for GAD and facilitating the future accurate clinical diagnosis and target treatment.

scholarly journals Disorder- and emotional context-specific neurofunctional alterations during inhibitory control in generalized anxiety disorder and major depressive disorder

2020 ◽  
Author(s):  
Congcong Liu ◽  
Jing Dai ◽  
Yuanshu Chen ◽  
Ziyu Qi ◽  
Fei Xin ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Inhibitory Control ◽  
First Episode ◽  
Generalized Anxiety ◽  
Major Depressive ◽  
Emotional Context ◽  
Dorsolateral Prefrontal ◽  
Treatment Naïve ◽  
Context Specific

AbstractBackgroundMajor Depressive (MDD) and Generalized Anxiety Disorder (GAD) are highly debilitating and often co-morbid disorders. The disorders exhibit partly overlapping dysregulations on the behavioral and neurofunctional level, and the determination of disorder-specific alterations may promote neuro-mechanistic and diagnostic specificity.MethodsIn order to determine disorder-specific alterations in the domain of emotion-cognition interactions the present study examined emotional context-specific inhibitory control in treatment-naïve, first-episode MDD (n = 37) and GAD (n = 35) patients and healthy controls (n = 35) by employing a validated affective go/no-go fMRI paradigm.FindingsOn the behavioral level MDD but not GAD patients exhibited impaired inhibitory control irrespective of emotional context. On the neural level, no alterations were observed during the positive context, yet specifically MDD patients demonstrated attenuated recruitment of a broad bilateral network encompassing inferior/medial parietal, posterior frontal, and mid-cingulate regions during inhibitory control in the negative context. GAD patients exhibited a stronger engagement of the left dorsolateral prefrontal cortex relative to MDD patients and within the GAD group better inhibitory control in negative contexts was associated with higher recruitment of this region.InterpretationFindings from the present study suggest disorder- and emotional context-specific behavioral and neurofunctional deficits in inhibitory control in MDD in negative emotional contexts and may point to a depression-specific neuropathological and diagnostic marker. In contrast, GAD patients may maintain intact inhibitory performance via compensatory recruitment of prefrontal regulatory regions.

White matter integrity alterations in first episode, treatment-naive generalized anxiety disorder

2013 ◽  
Vol 148 (2-3) ◽  
pp. 196-201 ◽  
Author(s):  
Yan Zhang ◽  
Lingjiang Li ◽  
Rongjun Yu ◽  
Jun Liu ◽  
Jinsong Tang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
White Matter ◽  
Generalized Anxiety Disorder ◽  
White Matter Integrity ◽  
First Episode ◽  
Generalized Anxiety ◽  
Treatment Naïve
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