scholarly journals Differential alterations of resting-state functional connectivity in generalized anxiety disorder and panic disorder

2016 ◽  
Vol 37 (4) ◽  
pp. 1459-1473 ◽  
Author(s):  
Huiru Cui ◽  
Jie Zhang ◽  
Yicen Liu ◽  
Qingwei Li ◽  
Hui Li ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Panic Disorder ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals 1122 RESTING STATE FUNCTIONAL CONNECTIVITY IN PRIMARY INSOMNIA, GENERALIZED ANXIETY DISORDER AND CONTROLS

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A418-A418
Author(s):  
EF Pace-Schott ◽  
JP Zimmerman ◽  
RM Bottary ◽  
EG Lee ◽  
MR Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals Resting state functional connectivity in primary insomnia, generalized anxiety disorder and controls

2017 ◽  
Vol 265 ◽  
pp. 26-34 ◽  
Author(s):  
Edward F. Pace-Schott ◽  
Jared P. Zimmerman ◽  
Ryan M. Bottary ◽  
Erik G. Lee ◽  
Mohammed R. Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

scholarly journals Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naïve Patients With Generalized Anxiety Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Mei Wang ◽  
Lingxiao Cao ◽  
Hailong Li ◽  
Hongqi Xiao ◽  
Yao Ma ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Trait Anxiety ◽  
Resting State ◽  
Superior Temporal Gyrus ◽  
Anterior Cingulate ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity ◽  
Drug Naïve ◽  
State And Trait Anxiety

Objective: Although previous studies have reported on disrupted amygdala subregional functional connectivity in generalized anxiety disorder (GAD), most of these studies were conducted in GAD patients with comorbidities or with drug treatment. Besides, whether/how the amygdala subregional functional networks were associated with state and trait anxiety is still largely unknown.Methods: Resting-state functional connectivity of amygdala subregions, including basolateral amygdala (BLA) and centromedial amygdala (CMA) as seed, were mapped and compared between 37 drug-naïve, non-comorbidity GAD patients and 31 age- and sex-matched healthy controls (HCs). Relationships between amygdala subregional network dysfunctions and state/trait anxiety were examined using partial correlation analyses.Results: Relative to HCs, GAD patients showed weaker functional connectivity of the left BLA with anterior cingulate/medial prefrontal cortices. Significantly increased functional connectivity of right BLA and CMA with superior temporal gyrus and insula were also identified in GAD patients. Furthermore, these functional connectivities showed correlations with state and trait anxiety scores.Conclusions: These findings revealed abnormal functional coupling of amygdala subregions in GAD patients with regions involved in fear processing and emotion regulation, including anterior cingulate/medial prefrontal cortex and superior temporal gyrus, which provide the unique biological markers for GAD and facilitating the future accurate clinical diagnosis and target treatment.

scholarly journals Intrinsic Network Brain Dysfunction Correlates With Temporal Complexity in Generalized Anxiety Disorder and Panic Disorder

2021 ◽  
Vol 15 ◽  
Author(s):  
Li Xu ◽  
Huazhen Xu ◽  
Huachen Ding ◽  
Jinyang Li ◽  
Chun Wang
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Panic Disorder ◽  
Generalized Anxiety Disorder ◽  
Activity Patterns ◽  
Brain Dysfunction ◽  
Entire Group ◽  
Generalized Anxiety ◽  
Clustering Methods ◽  
Significant Difference

Background: Generalized anxiety disorder (GAD) and panic disorder (PD) are the two severe subtypes of anxiety disorders (ADs), which are similar in clinical manifestation, pathogenesis, and treatment. Earlier studies have taken a whole-brain perspective on GAD and PD in the assumption that intrinsic fluctuations are static throughout the entire scan. However, it has recently been suggested that the dynamic alternations in functional connectivity (FC) may reflect the changes in macroscopic neural activity patterns underlying the critical aspects of cognition and behavior, and thus may act as biomarkers of disease.Methods: In this study, the resting-state functional MRI (fMRI) data were collected from 26 patients with GAD, 22 patients with PD, and 26 healthy controls (HCs). We investigated dynamic functional connectivity (DFC) by using the group spatial independent component analysis, a sliding window approach, and the k-means clustering methods. For group comparisons, the temporal properties of DFC states were analyzed statistically.Results: The dynamic analysis demonstrated two discrete connectivity “States” across the entire group, namely, a more segregated State I and a strongly integrated State II. Compared with HCs, patients with both GAD and PD spent more time in the weakly within-network State I, while performing fewer transitions and dwelling shorter in the integrated State II. Additionally, the analysis of DFC strength showed that connections associated with ADs were identified including the regions that belonged to default mode (DM), executive control (EC), and salience (SA) networks, especially the connections between SA and DM networks. However, no significant difference was found between the GAD and PD groups in temporal features and connection strength.Conclusions: More common but less specific alterations were detected in the GAD and PD groups, which implied that they might have similar state-dependent neurophysiological mechanisms and, in addition, could hopefully help us better understand their abnormal affective and cognitive performances in the clinic.

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