Insula shows abnormal task‐evoked and resting‐state activity in first‐episode drug‐naïve generalized anxiety disorder

2020 ◽  
Vol 37 (7) ◽  
pp. 632-644 ◽  
Author(s):  
Huiru Cui ◽  
Bin Zhang ◽  
Wei Li ◽  
Hui Li ◽  
Jiaoyan Pang ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
First Episode ◽  
Generalized Anxiety ◽  
State Activity ◽  
Drug Naïve

scholarly journals 1122 RESTING STATE FUNCTIONAL CONNECTIVITY IN PRIMARY INSOMNIA, GENERALIZED ANXIETY DISORDER AND CONTROLS

SLEEP ◽  
2017 ◽  
Vol 40 (suppl_1) ◽  
pp. A418-A418
Author(s):  
EF Pace-Schott ◽  
JP Zimmerman ◽  
RM Bottary ◽  
EG Lee ◽  
MR Milad ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Primary Insomnia ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity

Identifying generalized anxiety disorder using resting state habenular circuitry

2019 ◽  
Vol 14 (5) ◽  
pp. 1406-1418 ◽  
Author(s):  
Zijuan Ma ◽  
Yuan Zhong ◽  
Christina S. Hines ◽  
Yun Wu ◽  
Yuting Li ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Generalized Anxiety Disorder ◽  
Resting State ◽  
Generalized Anxiety

scholarly journals Dysfunction of Resting-State Functional Connectivity of Amygdala Subregions in Drug-Naïve Patients With Generalized Anxiety Disorder

2021 ◽  
Vol 12 ◽  
Author(s):  
Mei Wang ◽  
Lingxiao Cao ◽  
Hailong Li ◽  
Hongqi Xiao ◽  
Yao Ma ◽  
...  
Keyword(s):  
Anxiety Disorder ◽  
Functional Connectivity ◽  
Trait Anxiety ◽  
Resting State ◽  
Superior Temporal Gyrus ◽  
Anterior Cingulate ◽  
Generalized Anxiety ◽  
Resting State Functional Connectivity ◽  
Drug Naïve ◽  
State And Trait Anxiety

Objective: Although previous studies have reported on disrupted amygdala subregional functional connectivity in generalized anxiety disorder (GAD), most of these studies were conducted in GAD patients with comorbidities or with drug treatment. Besides, whether/how the amygdala subregional functional networks were associated with state and trait anxiety is still largely unknown.Methods: Resting-state functional connectivity of amygdala subregions, including basolateral amygdala (BLA) and centromedial amygdala (CMA) as seed, were mapped and compared between 37 drug-naïve, non-comorbidity GAD patients and 31 age- and sex-matched healthy controls (HCs). Relationships between amygdala subregional network dysfunctions and state/trait anxiety were examined using partial correlation analyses.Results: Relative to HCs, GAD patients showed weaker functional connectivity of the left BLA with anterior cingulate/medial prefrontal cortices. Significantly increased functional connectivity of right BLA and CMA with superior temporal gyrus and insula were also identified in GAD patients. Furthermore, these functional connectivities showed correlations with state and trait anxiety scores.Conclusions: These findings revealed abnormal functional coupling of amygdala subregions in GAD patients with regions involved in fear processing and emotion regulation, including anterior cingulate/medial prefrontal cortex and superior temporal gyrus, which provide the unique biological markers for GAD and facilitating the future accurate clinical diagnosis and target treatment.

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