Upregulated nicotinic ACh receptor signaling contributes to intestinal stem cell function through activation of Hippo and Notch signaling pathways

2020 ◽  
Vol 88 ◽  
pp. 106984
Author(s):  
Toshio Takahashi ◽  
Akira Shiraishi ◽  
Masatake Osawa
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Signaling Pathways ◽  
Cell Function ◽  
Intestinal Stem Cell ◽  
Receptor Signaling

L-Arginine Enhances Intestinal Stem Cell Function

2019 ◽  
Author(s):  
Qihang Hou ◽  
Qinghua Yu ◽  
Yuanyang Dong ◽  
Xiaoxi Lu ◽  
Lulu Ye ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell

scholarly journals Injury-associated reacquiring of intestinal stem cell function

2015 ◽  
Vol 21 (7) ◽  
pp. 2005-2010 ◽  
Author(s):  
Ferenc Sipos ◽  
Györgyi Műzes
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell

scholarly journals Notch Signaling Regulates Mammary Stem Cell Function and Luminal Cell-Fate Commitment

2008 ◽  
Vol 3 (4) ◽  
pp. 429-441 ◽  
Author(s):  
Toula Bouras ◽  
Bhupinder Pal ◽  
François Vaillant ◽  
Gwyndolen Harburg ◽  
Marie-Liesse Asselin-Labat ◽  
...  
Keyword(s):  
Stem Cell ◽  
Notch Signaling ◽  
Cell Fate ◽  
Cell Function ◽  
Mammary Stem Cell ◽  
Luminal Cell ◽  
Mammary Stem

scholarly journals mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Nature ◽  
2012 ◽  
Vol 486 (7404) ◽  
pp. 490-495 ◽  
Author(s):  
Ömer H. Yilmaz ◽  
Pekka Katajisto ◽  
Dudley W. Lamming ◽  
Yetis Gültekin ◽  
Khristian E. Bauer-Rowe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Paneth Cell ◽  
Intestinal Stem Cell ◽  
Calorie Intake ◽  
Cell Niche

scholarly journals Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Moritz Middelhoff ◽  
Henrik Nienhüser ◽  
Giovanni Valenti ◽  
H. Carlo Maurer ◽  
Yoku Hayakawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Feedback Inhibition ◽  
Cell Number ◽  
Intestinal Stem Cell ◽  
Compensatory Mechanism ◽  
Intestinal Epithelial ◽  
Immune Functions ◽  
Cholinergic Blockade ◽  
Tuft Cells

AbstractThe enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic Gq-coupled receptors such as M3R. Its role in the regulation of intestinal stem cell function and differentiation, however, has not been clarified. Here, we find that nonselective muscarinic receptor antagonism in mice as well as epithelial-specific ablation of M3R induces a selective expansion of DCLK1-positive tuft cells, suggesting a model of feedback inhibition. Cholinergic blockade reduces Lgr5-positive intestinal stem cell tracing and cell number. In contrast, Prox1-positive endocrine cells appear as primary sensors of cholinergic blockade inducing the expansion of tuft cells, which adopt an enteroendocrine phenotype and contribute to increased mucosal levels of acetylcholine. This compensatory mechanism is lost with acute irradiation injury, resulting in a paucity of tuft cells and acetylcholine production. Thus, enteroendocrine tuft cells appear essential to maintain epithelial homeostasis following modifications of the cholinergic intestinal niche.

scholarly journals Drosophila Myc integrates multiple signaling pathways to regulate intestinal stem cell proliferation during midgut regeneration

Cell Research ◽  
2013 ◽  
Vol 23 (9) ◽  
pp. 1133-1146 ◽  
Author(s):  
Fangfang Ren ◽  
Qing Shi ◽  
Yongbin Chen ◽  
Alice Jiang ◽  
Y Tony Ip ◽  
...  
Keyword(s):  
Cell Proliferation ◽  
Stem Cell ◽  
Signaling Pathways ◽  
Intestinal Stem Cell ◽  
Stem Cell Proliferation ◽  
Multiple Signaling

scholarly journals Thyroid Hormone-Induced Activation of Notch Signaling is Required for Adult Intestinal Stem Cell Development DuringXenopus LaevisMetamorphosis

Stem Cells ◽  
2016 ◽  
Vol 35 (4) ◽  
pp. 1028-1039 ◽  
Author(s):  
Takashi Hasebe ◽  
Kenta Fujimoto ◽  
Mitsuko Kajita ◽  
Liezhen Fu ◽  
Yun-Bo Shi ◽  
...  
Keyword(s):  
Stem Cell ◽  
Thyroid Hormone ◽  
Notch Signaling ◽  
Cell Development ◽  
Intestinal Stem Cell

scholarly journals Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

Cell Reports ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. 740-754 ◽  
Author(s):  
Victoria Llado ◽  
Yuki Nakanishi ◽  
Angeles Duran ◽  
Miguel Reina-Campos ◽  
Phillip M. Shelton ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell
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