scholarly journals The Coordinated Activities of nAChR and Wnt Signaling Regulate Intestinal Stem Cell Function in Mice

2018 ◽  
Vol 19 (3) ◽  
pp. 738 ◽  
Author(s):  
Toshio Takahashi ◽  
Akira Shiraishi ◽  
Jun Murata
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Cell Function ◽  
Intestinal Stem Cell

L-Arginine Enhances Intestinal Stem Cell Function

2019 ◽  
Author(s):  
Qihang Hou ◽  
Qinghua Yu ◽  
Yuanyang Dong ◽  
Xiaoxi Lu ◽  
Lulu Ye ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell

scholarly journals Injury-associated reacquiring of intestinal stem cell function

2015 ◽  
Vol 21 (7) ◽  
pp. 2005-2010 ◽  
Author(s):  
Ferenc Sipos ◽  
Györgyi Műzes
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell

scholarly journals mTORC1 in the Paneth cell niche couples intestinal stem-cell function to calorie intake

Nature ◽  
2012 ◽  
Vol 486 (7404) ◽  
pp. 490-495 ◽  
Author(s):  
Ömer H. Yilmaz ◽  
Pekka Katajisto ◽  
Dudley W. Lamming ◽  
Yetis Gültekin ◽  
Khristian E. Bauer-Rowe ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Paneth Cell ◽  
Intestinal Stem Cell ◽  
Calorie Intake ◽  
Cell Niche

scholarly journals Prox1-positive cells monitor and sustain the murine intestinal epithelial cholinergic niche

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Moritz Middelhoff ◽  
Henrik Nienhüser ◽  
Giovanni Valenti ◽  
H. Carlo Maurer ◽  
Yoku Hayakawa ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Feedback Inhibition ◽  
Cell Number ◽  
Intestinal Stem Cell ◽  
Compensatory Mechanism ◽  
Intestinal Epithelial ◽  
Immune Functions ◽  
Cholinergic Blockade ◽  
Tuft Cells

AbstractThe enteric neurotransmitter acetylcholine governs important intestinal epithelial secretory and immune functions through its actions on epithelial muscarinic Gq-coupled receptors such as M3R. Its role in the regulation of intestinal stem cell function and differentiation, however, has not been clarified. Here, we find that nonselective muscarinic receptor antagonism in mice as well as epithelial-specific ablation of M3R induces a selective expansion of DCLK1-positive tuft cells, suggesting a model of feedback inhibition. Cholinergic blockade reduces Lgr5-positive intestinal stem cell tracing and cell number. In contrast, Prox1-positive endocrine cells appear as primary sensors of cholinergic blockade inducing the expansion of tuft cells, which adopt an enteroendocrine phenotype and contribute to increased mucosal levels of acetylcholine. This compensatory mechanism is lost with acute irradiation injury, resulting in a paucity of tuft cells and acetylcholine production. Thus, enteroendocrine tuft cells appear essential to maintain epithelial homeostasis following modifications of the cholinergic intestinal niche.

Wnt3a nonredundantly controls hematopoietic stem cell function and its deficiency results in complete absence of canonical Wnt signaling

Blood ◽  
2010 ◽  
Vol 116 (3) ◽  
pp. 496-497 ◽  
Author(s):  
Tiago C. Luis ◽  
Brigitta A. E. Naber ◽  
Willem E. Fibbe ◽  
Jacques J. M. van Dongen ◽  
Frank J. T. Staal
Keyword(s):  
Stem Cell ◽  
Wnt Signaling ◽  
Hematopoietic Stem Cell ◽  
Cell Function ◽  
Canonical Wnt Signaling ◽  
Hematopoietic Stem ◽  
Canonical Wnt

scholarly journals Repression of Intestinal Stem Cell Function and Tumorigenesis through Direct Phosphorylation of β-Catenin and Yap by PKCζ

Cell Reports ◽  
2015 ◽  
Vol 10 (5) ◽  
pp. 740-754 ◽  
Author(s):  
Victoria Llado ◽  
Yuki Nakanishi ◽  
Angeles Duran ◽  
Miguel Reina-Campos ◽  
Phillip M. Shelton ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cell Function ◽  
Intestinal Stem Cell
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