scholarly journals The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation

2016 ◽  
Vol 171 ◽  
pp. 60-69 ◽  
Author(s):  
Zoltan Petho ◽  
Andras Balajthy ◽  
Adam Bartok ◽  
Krisztian Bene ◽  
Sandor Somodi ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cation Channel ◽  
Channel Blockers ◽  
Mitogenic Stimulation ◽  
Proliferative Effect

scholarly journals The Anti-Proliferative Effect of Cation Channel Blockers on T Lymphocytes Stimulated by Anti-CD3 and Anti-CD28

2015 ◽  
Vol 108 (2) ◽  
pp. 586a-587a
Author(s):  
Zoltan Varga ◽  
Zoltan Petho ◽  
Andras Balajthy ◽  
Adam Bartok ◽  
Sandor Somodi ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cation Channel ◽  
Channel Blockers ◽  
Proliferative Effect

scholarly journals Membrane dielectric responses of human T-lymphocytes following mitogenic stimulation

1999 ◽  
Vol 1417 (1) ◽  
pp. 51-62 ◽  
Author(s):  
Ying Huang ◽  
Xiao-Bo Wang ◽  
Peter R.C. Gascoyne ◽  
Frederick F. Becker
Keyword(s):  
T Lymphocytes ◽  
Mitogenic Stimulation ◽  
Human T Lymphocytes

scholarly journals Proliferative effect of the calcium channel blocker Nifedipine on human embryonic kidney cells

2018 ◽  
Vol 7 (7) ◽  
pp. 1226 ◽  
Author(s):  
Jamil L. Ahmad ◽  
Chukwudi C. Okebaram ◽  
Emmanuel O. Ogbuagu ◽  
Chidozie N. Ogbonnaya ◽  
Geoffrey C. Asobie
Keyword(s):  
Calcium Channel ◽  
Hek293 Cells ◽  
Cell Counting ◽  
Blue Dye ◽  
Channel Blockers ◽  
Human Embryonic Kidney ◽  
Proliferative Effect ◽  
Increased Risk ◽  
Chronic Use

Background: Numerous epidemiological studies have shown a positive as well as negative association between chronic use of calcium channel blockers and the increased risk of developing cancer. However, these associations were enmeshed with controversies in the absence of laboratory based studies to back up those claims. The aim was to determine in mechanistic terms the association between the long-term administrations of nifedipineand increased risk of developing cancer with the aid of human embryonic kidney (HEK293) cell line.Methods: Cell counting using the Trypan blue dye exclusion and 3-[4, 5-Dimethylthiazol-2-yl]-2, 5-diphenyl-tetrazolium bromide (MTT) assays were used to investigate the effect of nifedipine on the growth pattern of HEK293 cells.Results: Nifedipine had a proliferative effect on HEK293 cells growth and this proliferation is more profound at low concentrations of nifedipine than high concentrations and the proliferation was statistically significant (p<0.01).Conclusions: The chronic use of nifedipine is associated with increased proliferation of cells with concomitant elevation of polyamines concentration and elevated polyamine levels have been implicated in many malignant transformations and hence, these provide possible explanation on the link between long term use of nifedipine and development of some human cancers.

Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

2011 ◽  
Vol 51 (5) ◽  
pp. 1256-1260 ◽  
Author(s):  
Jenny Barbier ◽  
Rolf Jansen ◽  
Herbert Irschik ◽  
Stefan Benson ◽  
Klaus Gerth ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cation Channel ◽  
Channel Blockers ◽  
Sorangium Cellulosum ◽  
Antifungal Antibiotics
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