Effects of Mechano-Gated Cation Channel Blockers on Xenopus Oocyte Growth and Development

1998 ◽  
Vol 165 (2) ◽  
pp. 161-174 ◽  
Author(s):  
N.C. Wilkinson ◽  
F. Gao ◽  
O.P. Hamill
Keyword(s):  
Growth And Development ◽  
Xenopus Oocyte ◽  
Cation Channel ◽  
Channel Blockers ◽  
Oocyte Growth

scholarly journals The anti-proliferative effect of cation channel blockers in T lymphocytes depends on the strength of mitogenic stimulation

2016 ◽  
Vol 171 ◽  
pp. 60-69 ◽  
Author(s):  
Zoltan Petho ◽  
Andras Balajthy ◽  
Adam Bartok ◽  
Krisztian Bene ◽  
Sandor Somodi ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cation Channel ◽  
Channel Blockers ◽  
Mitogenic Stimulation ◽  
Proliferative Effect

scholarly journals The Anti-Proliferative Effect of Cation Channel Blockers on T Lymphocytes Stimulated by Anti-CD3 and Anti-CD28

2015 ◽  
Vol 108 (2) ◽  
pp. 586a-587a
Author(s):  
Zoltan Varga ◽  
Zoltan Petho ◽  
Andras Balajthy ◽  
Adam Bartok ◽  
Sandor Somodi ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cation Channel ◽  
Channel Blockers ◽  
Proliferative Effect

Isolation and Total Synthesis of Icumazoles and Noricumazoles-Antifungal Antibiotics and Cation-Channel Blockers from Sorangium cellulosum

2011 ◽  
Vol 51 (5) ◽  
pp. 1256-1260 ◽  
Author(s):  
Jenny Barbier ◽  
Rolf Jansen ◽  
Herbert Irschik ◽  
Stefan Benson ◽  
Klaus Gerth ◽  
...  
Keyword(s):  
Total Synthesis ◽  
Cation Channel ◽  
Channel Blockers ◽  
Sorangium Cellulosum ◽  
Antifungal Antibiotics

Role of phosphoinositide 3-kinase in the nonselective cation channel activation by endothelin-1/endothelinBreceptor

2003 ◽  
Vol 284 (2) ◽  
pp. C506-C510 ◽  
Author(s):  
Yoshifumi Kawanabe ◽  
Nobuo Hashimoto ◽  
Tomoh Masaki
Keyword(s):  
Chinese Hamster ◽  
Pi3k Pathway ◽  
Cation Channel ◽  
Channel Blockers ◽  
Nonselective Cation Channel ◽  
Channel Activation ◽  
Endothelin 1 ◽  
Ovarian Cells ◽  
Phosphoinositide 3 Kinase

We recently demonstrated that endothelin-1 (ET-1) activates two types of Ca2+-permeable nonselective cation channel (designated NSCC-1 and NSCC-2) in Chinese hamster ovarian cells expressing endothelinB receptor (CHO-ETBR). These channels can be discriminated using the Ca2+ channel blockers, LOE 908 and SK&F 96365. LOE 908 is a blocker of NSCC-1 and NSCC-2, whereas SK&F 96365 is a blocker of NSCC-2. In this study, we investigated the possible role of phosphoinositide 3-kinase (PI3K) in the ET-1-induced activation of NSCCs in CHO-ETBR using wortmannin and LY-294002, inhibitors of PI3K. ET-1-induced Ca2+ influx was partially inhibited in CHO-ETBR pretreated with wortmannin or LY-294002. In contrast, addition of wortmannin or LY-294002 after stimulation with ET-1 did not suppress Ca2+ influx. The Ca2+ channels activated by ET-1 in wortmannin- or LY-294002-treated CHO-ETBR were sensitive to LOE 908 and resistant to SK&F 96365. In conclusion, NSCC-2 is stimulated by ET-1 via PI3K-dependent cascade, whereas NSCC-1 is stimulated independently of the PI3K pathway. Moreover, PI3K seems to be required for the initiation of the Ca2+ entry through NSCC-2 but not for its maintenance.

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