Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

2013 ◽  
Vol 61 ◽  
pp. 28-35 ◽  
Author(s):  
Mehmet Tokaç ◽  
Gökçe Taner ◽  
Sevtap Aydın ◽  
Alper Bilal Özkardeş ◽  
Halit Ziya Dündar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Biliary Obstruction ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

2015 ◽  
Vol 167 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Fatih Dilek ◽  
Emin Ozkaya ◽  
Abdurrahim Kocyigit ◽  
Mebrure Yazici ◽  
Siddika Kesgin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Stress Parameters ◽  
Children With Asthma ◽  
Stress Parameters

scholarly journals Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

2019 ◽  
Vol 25 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Abdelkader Oumeddour ◽  
Djahida Zaroure ◽  
Raziqua Haroune ◽  
Rima Zaimeche ◽  
Karima Riane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Total Protein ◽  
Serum Biochemistry ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Therapeutic Benefits ◽  
Sugar Levels ◽  
Stress Parameters

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

scholarly journals Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

2008 ◽  
Vol 10 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Bekir S. Parlaktas ◽  
Birsen Ozyurt ◽  
Huseyin Ozyurt ◽  
Ayten T. Tunc ◽  
Ali Akbas
Keyword(s):  
Oxidative Stress ◽  
Protective Effects ◽  
Rat Testis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

2013 ◽  
Vol 64 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Umit Aydogan ◽  
Emre Durmaz ◽  
Cihangir Mutlu Ercan ◽  
Ayse Eken ◽  
Onur Kenan Ulutas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Damage ◽  
Cord Blood ◽  
Third Trimester ◽  
Smoking During Pregnancy ◽  
Oxidative Stress Parameters ◽  
Carcinogenic Substances ◽  
Plasma Nitrite ◽  
Stress Parameters

Some of the genotoxic/carcinogenic substances or metabolites in cigarette smoke are capable of passing through the placenta and harming a newborn’s health. Smoking is also known as a factor in the formation of oxidative damage and the main mechanism involved in the carcinogenic process. Predetermining this genotoxic risk can be successfully achieved by measuring certain parameters of oxidative stress. The comet assay is considered an important biomarker for the evaluation of genotoxic substances and is effective for detecting DNA damage caused by smoking. This study examined third trimester bloods and the cord blood of 28 actively smoking and 22 non-smoking mothers in terms of DNA damage and oxidative stress parameters. Cu/Zn superoxide dismutase (CuZn-SOD), malondialdehyde (MDA), catalase (CAT), plasma nitrite/nitrates (NO2 -/NO3 -), selenium-dependent glutathione peroxidase (Se-GPx), Cu, and Zn levels were measured as indicators of oxidative damage. There were no significant increases in DNA damage of the actively smoking pregnant group in comparison with the non-smoking pregnant group, either in the third trimester or cord blood. Oxidative stress parameters of smoker and non-smoker groups were statistically different for MDA (p<0.05), CuZn-SOD (p<0.01), Se-GPx (p<0.05) values while the difference was not significant for NO2 -/NO3 -, CAT, Zn, and Cu values. The same values were also investigated in cord blood, and only NO2/NO3 -(p<0.01), Se-GPx (p<0.01 and CAT (p<0.001) values were found statistically different. Smoking mothers may have been exposed to more oxidative stress than non-smoking mothers.

scholarly journals Chemoprotective Potential of Helianthemum confertum Against the Loss of Molecular and Functional Integrity of the Liver Cell in Doxorubicin-Treated Rats

2018 ◽  
Vol 9 (07) ◽  
Author(s):  
Radja Djebbari ◽  
Yasmine Chemam ◽  
Nassima Boubekri ◽  
Zohra Lakroun ◽  
Mohammed Kebieche ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Liver Function ◽  
Histological Study ◽  
Antioxidant Properties ◽  
Liver Cells ◽  
Male Rats ◽  
Protective Effects ◽  
Butanol Extract ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

The objective of the current study was led to reveal the possible protective effects of n-butanol extract of Helianthemum confertum (H. confertum) against doxorubicin (DOX) induced liver damage and its implication on the integrity of liver cells. Adult male rats were randomly divided into groups treated with plant extract (50 mg/kg, 100 mg/kg) for 10 days and/or injected with a single dose of DOX (10 mg/kg). Liver function as well as oxidative stress parameters and histological study were estimated. DOX treated rat’s induced hepatic dysfunction revealed by a significant increase in biochemical parameters (serum transaminases, cholesterol and triglycerides) and disturbance in oxidative stress parameters described by an increase in malondialdehyde (MDA) levels, providing information on the loss of cellular integrity. This later elicited histopathological changes in the liver which was confirmed on histological section chowing necrotic cells. Altghout the DOX-treatment reduced significantly the reduced glutathione (GSH) level and the glutathione peroxidase (GPx) activity. The pretreatment of the animals with n-butanol extract of H. confertumat 50 mg/kg and 100 mg/kg counteracted almost all adverse effects induced by DOX. The results showed a considerable decrease in serum markers of liver function and lipid peroxides. There was significant increase in the GSH level and the activity of antioxidant enzyme (GPx), which allowed the normalization of redox status in liver cells. Data suggest that DOX-induced an oxidative stress in rat’s liver and nbutanol extract of H. confertum exerted antioxidant properties.

Sign in / Sign up

Export Citation Format

Share Document