scholarly journals Protective Effects of Propolis and Probiotic Lactobacillus acidophilus against Carbon Tetrachloride-Induced Hepatotoxicity in Rats

2019 ◽  
Vol 25 (3) ◽  
pp. 190-197 ◽  
Author(s):  
Abdelkader Oumeddour ◽  
Djahida Zaroure ◽  
Raziqua Haroune ◽  
Rima Zaimeche ◽  
Karima Riane ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Carbon Tetrachloride ◽  
Total Protein ◽  
Serum Biochemistry ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Therapeutic Benefits ◽  
Sugar Levels ◽  
Stress Parameters

Background: Propolis (PRS) and probiotic bacteria Lactobacillus are natural products used as dietary supplement for their therapeutic benefits. This study was performed to examine the possible hepatoprotective effect of PRS and probiotics (PRCs) against carbon tetrachloride-induced liver injury. Methods: Experimentally, intoxicated rats received 0.5 ml/kg CCl4 (i.p.) daily for six days, pretreated rats received per os PRS 100 mg/kg or PRCs 109 CFU for six days followed by a single dose of 0.5 ml/kg CCl4. Control groups received either PRS, PRCs or olive oil for six days. Then, serum biochemistry (total protein, cholesterol, triglycerides and albumin) and oxidative stress parameters were measured. Results: We showed that CCl4 treatment was associated with an increase of the serum aspartate amino transferase (AST), alanine aminotransferase (ALT), cholesterol and triglycerides levels. In parallel, serum total protein, albumin and blood sugar levels were significantly decreased. Regarding the oxidative stress parameters, catalase and glutathione S-transferase (GST) levels were lower, conversely to the lipid peroxidation (MDA). Conclusion: Our results strongly support that administration of PRS and PRCs may significantly protect liver against CCl4-induced toxicity by enhancing antioxidative stress pathway and preventing lipid peroxidation.

scholarly journals Effects of High Dietary Fluoride on Serum Biochemistry and Oxidative Stress Parameters in Broiler Chickens

Health ◽  
2014 ◽  
Vol 06 (14) ◽  
pp. 1840-1848 ◽  
Author(s):  
Yubing Deng ◽  
Hengmin Cui ◽  
Xi Peng ◽  
Jing Fang ◽  
Zhicai Zuo ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Broiler Chickens ◽  
Serum Biochemistry ◽  
Oxidative Stress Parameters ◽  
And Oxidative Stress ◽  
Stress Parameters

scholarly journals Hepatoprotective effect of desi and kabuli cultivars of Cicer arietinum L (chick peas) against carbon tetrachloride-induced toxicity in rats

2020 ◽  
Vol 19 (3) ◽  
pp. 609-615
Author(s):  
Mudasir Majeed ◽  
Abdullah Ijaz Hussain ◽  
Haseeb Anwar ◽  
Shahzad Irfan ◽  
Shahzad Ali Shahid Chatha ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Carbon Tetrachloride ◽  
Cicer Arietinum ◽  
Control Group ◽  
Serum Samples ◽  
Cicer Arietinum L ◽  
Oxidative Stress Parameters ◽  
High Doses ◽  
Ethanol Extracts ◽  
Stress Parameters

Purpose: To determine the hepatoprotective potential of ethanol extracts of desi and kabuli cultivars of Cicer arietinum L. (chick peas). Methods: Hepatotoxicity was induced in rats using oral administration of carbon tetrachloride (CCl4). The rats were then orally administered different doses of the ethanol extracts of desi and kabuli cultivars of Cicer arietinum L. for 21 days. Oxidative stress parameters and hepatoprotective profiles were determined in serum samples using standard procedures. The effect of the treatments on liver histology was also determined. Results: Administration of extracts of desi and kabuli cultivars of Cicer arietinum L. to CCl4 treated rats at a dose of 300 mg/kg resulted in a significant (p ≤ 0.05) decrease in oxidative stress parameters, whereas catalase activity significantly increased (p ≤ 0.05); on the other hand, ALT and AST levels were decreased significantly (p ≤ 0.05), when compared to the control group. Conclusion: High doses of Cicer arietinum L (desi and kabuli cultivars) seem to have hepatoprotective and antioxidant effects on CCl4-induced toxicity in rats. This finding underscores the therapeutic importance of Cicer arietinum L. as a plant with hepatoprotective properties. Keywords: Cicer arietinum, Phenolics, Hepatotoxicity, Chick peas, Catalase

Effect of toluene on erythrocyte membrane stability under in vivo and in vitro conditions with assessment of oxidant/antioxidant status

2009 ◽  
Vol 25 (8) ◽  
pp. 545-550 ◽  
Author(s):  
Ismail Karabulut ◽  
Z. Dicle Balkanci ◽  
Bilge Pehlivanoglu ◽  
Aysen Erdem ◽  
Ersin Fadillioglu
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Unsaturated Fatty Acids ◽  
Osmotic Fragility ◽  
Human Erythrocytes ◽  
Antioxidant Enzyme Activities ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Toluene, an organic solvent used widely in the industry, is highly lipophilic and accumulates in the cell membrane impeding transport through it. Its metabolites cause oxygen radical formation that react with unsaturated fatty acids and proteins in erythrocytes leading to lipid peroxidation and protein breakdown. In this study, we aimed to investigate the membrane stabilizing and the oxidative stress—inducing effects of toluene in human erythrocytes. Measurements of osmotic fragility, mean corpuscular volume (MCV), oxidative stress parameters and antioxidant enzyme activities were performed simultaneously both in individuals exposed to toluene professionally (in vivo) and human erythrocytes treated with toluene (in vitro). To measure osmotic fragility, erythrocytes were placed in NaCl solutions at various concentrations (0.1% [blank], 0.38%, 0.40%, 0.42%, 0.44%, 0.46%, 0.48% and 1% [stock]). Percentage of haemolysis in each solution was calculated with respect to the 100% haemolysis in the blank solution. The erythrocyte packs prepared at the day of the above-mentioned measurements were kept at —80°C until the time for determination of malonyldialdehyde and protein carbonyl levels, and catalase (CAT) and glutathione peroxidase activities as indicators of oxidative stress. Toluene increased oxidative stress parameters significantly both in vivo and in vitro; it also caused a significant decrease in the activities of antioxidant enzymes. Osmotic fragility was altered only in the case of in vitro exposure. In conclusion, toluene exposure resulted in increased lipid peroxidation and protein damage both in vivo and in vitro. Although, it is natural to expect increased osmotic fragility due to oxidative properties of toluene, its membrane-stabilizing effect overcame the oxidative properties leading to decreased osmotic fragility or preventing its deterioration in vitro and in vivo toluene exposures, respectively, in the present study.

scholarly journals EFFECT OF TOCOTRIENOL PRETREATMENT ON EX VIVO SUPEROXIDE AND PEROXIDE HANDLING CAPACITIES (SPHC) OF RAT SERUM AND BRAIN

2017 ◽  
Vol 9 (3) ◽  
pp. 116
Author(s):  
Pitchaiah Dasari ◽  
Anandamurali R. ◽  
Prasunpriya Nayak
Keyword(s):  
Oxidative Stress ◽  
Lipid Peroxidation ◽  
Ex Vivo ◽  
Reduced Glutathione ◽  
Temporal Cortex ◽  
Antioxidant Property ◽  
Brain Regions ◽  
Rat Serum ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Objective: Tocotrienol (TT), a constituent of vitamin E, present only in selected seed oil. Because of the isoprenoid side chain, antioxidant property of tocotrienol is recently highlighted. Application of tocotrienol is also proven to be neuroprotective. The current study was aimed to evaluate the effect of tocotrienol pretreatment on the serum and brain oxidative stress parameters and oxidant handling capacities.Methods: Male albino Wistar rats were treated with tocotrienol (10 mg/day) for two weeks and maintained for the next four weeks. Levels of reduced glutathione and lipid peroxidation and activities of superoxide dismutase, catalase, glutathione peroxidase and glutathione reductase were estimated fortnightly in serum. After sacrifice, oxidative stress parameters were measured in the frontal cortex, temporal cortex, thalamic area, hippocampus and cerebellum. Glutathione-dependent and glutathione-independent superoxide and peroxide handling capacities (SPHC) were calculated for serum and brain regions. Data collected from both the groups are statistically processed with Kruskal-Wallis test and Mann-Whitney pairwise comparisons.Results: Significant impacts of TT treatment have been observed in terms of growth and water intake. Serum SPHC (Glutathione-independent) has been found to be reduced significantly immediately after the TT treatment. Region-specific alterations in oxidative stress parameters have also been observed after 4 w of supplementation. Global reductions in reduced glutathione and lipid peroxidation have been observed in the brain without any alteration in the SPHC.Conclusion: From the results, it can be suggested that the tocotrienol pretreatment possibly be used as neuroprotective measure particularly against oxidative stress. In addition, the antioxidant impacts of TT were found to be maintained for a longer period in brain regions, even though it was not so in the case of serum.

scholarly journals Levels of oxidative stress parameters and the protective effects of melatonin in psychosis model rat testis

2008 ◽  
Vol 10 (2) ◽  
pp. 259-265 ◽  
Author(s):  
Bekir S. Parlaktas ◽  
Birsen Ozyurt ◽  
Huseyin Ozyurt ◽  
Ayten T. Tunc ◽  
Ali Akbas
Keyword(s):  
Oxidative Stress ◽  
Protective Effects ◽  
Rat Testis ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

2013 ◽  
Vol 61 ◽  
pp. 28-35 ◽  
Author(s):  
Mehmet Tokaç ◽  
Gökçe Taner ◽  
Sevtap Aydın ◽  
Alper Bilal Özkardeş ◽  
Halit Ziya Dündar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Biliary Obstruction ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Stress Parameters
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