scholarly journals Effect of Montelukast Monotherapy on Oxidative Stress Parameters and DNA Damage in Children with Asthma

2015 ◽  
Vol 167 (2) ◽  
pp. 119-126 ◽  
Author(s):  
Fatih Dilek ◽  
Emin Ozkaya ◽  
Abdurrahim Kocyigit ◽  
Mebrure Yazici ◽  
Siddika Kesgin ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Stress Parameters ◽  
Children With Asthma ◽  
Stress Parameters

scholarly journals Effects of Smoking during Pregnancy on DNA Damage and ROS Level Consequences in Maternal and Newborns’ Blood

2013 ◽  
Vol 64 (1) ◽  
pp. 35-46 ◽  
Author(s):  
Umit Aydogan ◽  
Emre Durmaz ◽  
Cihangir Mutlu Ercan ◽  
Ayse Eken ◽  
Onur Kenan Ulutas ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Damage ◽  
Cord Blood ◽  
Third Trimester ◽  
Smoking During Pregnancy ◽  
Oxidative Stress Parameters ◽  
Carcinogenic Substances ◽  
Plasma Nitrite ◽  
Stress Parameters

Some of the genotoxic/carcinogenic substances or metabolites in cigarette smoke are capable of passing through the placenta and harming a newborn’s health. Smoking is also known as a factor in the formation of oxidative damage and the main mechanism involved in the carcinogenic process. Predetermining this genotoxic risk can be successfully achieved by measuring certain parameters of oxidative stress. The comet assay is considered an important biomarker for the evaluation of genotoxic substances and is effective for detecting DNA damage caused by smoking. This study examined third trimester bloods and the cord blood of 28 actively smoking and 22 non-smoking mothers in terms of DNA damage and oxidative stress parameters. Cu/Zn superoxide dismutase (CuZn-SOD), malondialdehyde (MDA), catalase (CAT), plasma nitrite/nitrates (NO2 -/NO3 -), selenium-dependent glutathione peroxidase (Se-GPx), Cu, and Zn levels were measured as indicators of oxidative damage. There were no significant increases in DNA damage of the actively smoking pregnant group in comparison with the non-smoking pregnant group, either in the third trimester or cord blood. Oxidative stress parameters of smoker and non-smoker groups were statistically different for MDA (p<0.05), CuZn-SOD (p<0.01), Se-GPx (p<0.05) values while the difference was not significant for NO2 -/NO3 -, CAT, Zn, and Cu values. The same values were also investigated in cord blood, and only NO2/NO3 -(p<0.01), Se-GPx (p<0.01 and CAT (p<0.001) values were found statistically different. Smoking mothers may have been exposed to more oxidative stress than non-smoking mothers.

Protective effects of curcumin against oxidative stress parameters and DNA damage in the livers and kidneys of rats with biliary obstruction

2013 ◽  
Vol 61 ◽  
pp. 28-35 ◽  
Author(s):  
Mehmet Tokaç ◽  
Gökçe Taner ◽  
Sevtap Aydın ◽  
Alper Bilal Özkardeş ◽  
Halit Ziya Dündar ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Biliary Obstruction ◽  
Protective Effects ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

scholarly journals The Oxidative Stress Parameters as Useful Tools in Evaluating the DNA Damage and Changes in the Complete Blood Count in Hospital Workers Exposed to Low Doses of Antineoplastic Drugs and Ionizing Radiation

2021 ◽  
Vol 18 (16) ◽  
pp. 8445
Author(s):  
Jasminka Mrdjanović ◽  
Slavica Šolajić ◽  
Branislava Srđenović-Čonić ◽  
Višnja Bogdanović ◽  
Dea Karaba-Jakovljević ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Ionizing Radiation ◽  
Blood Count ◽  
Complete Blood Count ◽  
Antineoplastic Drugs ◽  
Hospital Workers ◽  
Oxidative Stress Parameters ◽  
Occupationally Exposed ◽  
Stress Parameters

Hospital workers at the Oncology Department are occupationally exposed to antineoplastic drugs (ANTNP) or low doses of ionizing radiation (Irrad). Therefore, the aim of this study was to evaluate the level of DNA damage, the oxidative stress parameters and complete blood count (CBC) of hospital workers in order to analyze the negative health effects of ANTNP and low dose Irrad. The frequency of micronuclei (MN) and proliferation index (PI) were analyzed by cytokinesis-block test. The oxidative stress biomarkers evaluated were the level of lipid peroxidation in plasma and catalase activity (CAT) in erythrocytes. A group of 86 hospital workers (35 exposed to ANTPN and 51 to Irrad) had increased MN frequency, CAT activity and level of lipid peroxidation compared to the control group, which consisted of 24 volunteers. The hemoglobin level was lower in the ANTNP group compared to thecontrol group, while a significant difference in RBC was recorded between thecontrol and Irrad groups, and in platelet count betweentheIrrad and ANTNP group. The results showed increased DNA damage, oxidative stress parameters, as well as impairment on complete blood count in hospital workers occupationally exposed to antineoplastic drugs and low-dose ionizing radiation. As this research has shown the importance of oxidative stress, we suggest that in addition to routine methods in periodic medical evaluation, the possibility of applying oxidative stress parameters is considered. Moreover, hospital workers exposed to ANTNP and Irrad in the workplace should undergo not only a more complete health prevention procedure but also have a more appropriate health promotion.

DNA damage and its relationship with other oxidative stress parameters in Behcet’s disease

2010 ◽  
Vol 32 (1) ◽  
pp. 217-222 ◽  
Author(s):  
E. D. Sezer ◽  
K. Aksu ◽  
O. Caglayan ◽  
G. Keser ◽  
G. Karabulut ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Behçet’S Disease ◽  
Behcet’S Disease ◽  
Behçet's Disease ◽  
Behcet's Disease ◽  
Oxidative Stress Parameters ◽  
Stress Parameters

Occupational exposure assessment in professionals who manipulate and administer antineoplastic drugs in a university hospital in Southern Brazil

2021 ◽  
pp. 107815522110036
Author(s):  
Sandro Luis R Ness ◽  
Marcello Á Mascarenhas ◽  
Marcelo D Arbo ◽  
Bruna D Tonietto ◽  
Larissa V Cestonaro ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Occupational Exposure ◽  
Longitudinal Design ◽  
University Hospital ◽  
Antineoplastic Drugs ◽  
Southern Brazil ◽  
Oxidative Stress Parameters ◽  
Occupationally Exposed ◽  
Stress Parameters

Introduction Our goal was to demonstrate the effects of occupational exposure to antineoplastic drugs on oxidative stress parameters and DNA damage in health professionals who manipulate and administer antineoplastic drugs in a University Hospital in Southern Brazil. Methods The case-control study with a longitudinal design, involved 64 individuals, 29 of them pharmacists, pharmacy technicians and nurses who were occupationally exposed to antineoplastic drugs and 35 professionals who were not exposed. Gene mutations were determined by micronucleus from salivary fluid; DNA damage by comet assay and oxidative stress parameters in whole blood were also evaluated. Results All workers exposed to antineoplastic drugs used personal protective equipment (PPE). It was demonstrated that the total nonprotein thiol and thiobarbituric acid reactive substances levels showed interaction between group and time, with higher levels one week after handling/administration of antineoplastic drugs in the exposed group (GEE, p ≤ 0.0001 and p = 0,013, respectively). Additionally, there was a group effect on the activities of the catalase and glutathione peroxidase antioxidant enzymes (GEE, p = 0.027 and p ≤ 0.0001, respectively), and workers occupationally exposed to antineoplastic drugs had higher enzyme activities compared to those not exposed. No genotoxic damage was demonstrated through the evaluated parameters. Conclusions Despite the correct use of PPE, professionals occupationally exposed to antineoplastic drugs were more susceptible to oxidative stress than those not exposed. The evaluation of the studied parameters is especially important for the definition of conducts and practices in the area, always in search of guaranteeing the establishment of a rational policy to protect workers' health.

scholarly journals Effects of primaquine and chloroquine on oxidative stress parameters in rats

2015 ◽  
Vol 87 (2 suppl) ◽  
pp. 1487-1496 ◽  
Author(s):  
FRANCIANNE GIOVANELLA ◽  
GABRIELA K. FERREIRA ◽  
SAMIRA D.T. DE PRÁ ◽  
MILENA CARVALHO-SILVA ◽  
LARA M. GOMES ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Dna Damage ◽  
Oxidative Damage ◽  
Protein Carbonyls ◽  
Prolonged Treatment ◽  
Oxidative Stress Parameters ◽  
Chloroquine Treatment ◽  
Liver And Kidney ◽  
The Brain ◽  
Stress Parameters

Primaquine and chloroquine are used for the treatment of malaria; evidence from the literature suggests that these drugs may induce oxidative stress. In this study we investigated the effects of primaquine and chloroquine on oxidative damage and DNA damage in brain, liver and kidney of rats after 7, 14 and 21 days of administration. Our results demonstrated that primaquine causes DNA damage in brain after 7, 14 and 21 days, and in liver after 7 and 14 days. Moreover, primaquine increases TBARS levels in the kidney and protein carbonyls in the brain after 14 days, and decreases protein carbonyls in the liver after 7 days. Whereas chloroquine causes DNA damage in the kidney after 7 and 14 days, and in the liver after 14 and 21 days, increases TBARS levels in the kidney after 7 days, and decreases TBARS levels in the brain after 21 days. Moreover, decreases protein carbonyls in the liver after 7 and 14 days, and in the brain after 7 and 21 days. However, chloroquine treatment for 14 days increases protein carbonyls in the brain and kidney. In conclusion, these results showed that prolonged treatment with antimalarial may adversely affect the DNA.

Sign in / Sign up

Export Citation Format

Share Document