The role of insulin and neurotrophic factor signaling in brain aging and Alzheimer’s Disease

2007 ◽  
Vol 42 (1-2) ◽  
pp. 10-21 ◽  
Author(s):  
Greg M. Cole ◽  
Sally A. Frautschy
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neurotrophic Factor ◽  
Brain Aging ◽  
Neurotrophic Factor Signaling

Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging

2017 ◽  
Vol 61 (1) ◽  
pp. 259-263 ◽  
Author(s):  
Yu Hasegawa ◽  
Kensuke Toyama ◽  
Ken Uekawa ◽  
Hidenori Ichijo ◽  
Shokei Kim-Mitsuyama
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Brain Aging ◽  
Model Of Alzheimer’S Disease

Mechanisms of neuronal death in brain aging and alzheimer's disease: Role of endocrine-mediated calcium dyshomeostasis

1992 ◽  
Vol 23 (9) ◽  
pp. 1247-1260 ◽  
Author(s):  
Philip W. Landfield ◽  
Olivier Thibault ◽  
Mary L. Mazzanti ◽  
Nada M. Porter ◽  
D. Steven Kerr
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Neuronal Death ◽  
Brain Aging

Role of Nutrition to Promote Healthy Brain Aging and Reduce Risk of Alzheimer’s Disease

2017 ◽  
Vol 6 (2) ◽  
pp. 63-71 ◽  
Author(s):  
Michelle Walters ◽  
Katherine Hackett ◽  
Emily Caesar ◽  
Richard Isaacson ◽  
Lisa Mosconi
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Reduce Risk

Deciphering Alzheimer’s Disease Pathogenic Pathway: Role of Chronic Brain Hypoperfusion on p-Tau and mTOR

2021 ◽  
Vol 79 (4) ◽  
pp. 1381-1396
Author(s):  
Jack C. de la Torre
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Brain Aging ◽  
Memory Function ◽  
Mammalian Target Of Rapamycin ◽  
Tau Phosphorylation ◽  
Clinical Feature ◽  
Fast Axonal Transport ◽  
Current Topic

This review examines new biomolecular findings that lend support to the hemodynamic role played by chronic brain hypoperfusion (CBH) in driving a pathway to Alzheimer’s disease (AD). CBH is a common clinical feature of AD and the current topic of intense investigation in AD models. CBH is also the basis for the vascular hypothesis of AD which we originally proposed in 1993. New biomolecular findings reveal the interplay of CBH in increasing tau phosphorylation (p-Tau) in the hippocampus and cortex of AD mice, damaging fast axonal transport, increasing signaling of mammalian target of rapamycin (mTOR), impairing learning-memory function, and promoting the formation of neurofibrillary tangles, a neuropathologic hallmark of AD. These pathologic elements have been singularly linked with neurodegeneration and AD but their abnormal, collective participation during brain aging have not been fully examined. The format for this review will provide a consolidated analysis of each pathologic phase contributing to cognitive decline and AD onset, summarized in nine chronological steps. These steps galvanize each factor’s active participation and contribution in constructing a biomolecular pathway to AD onset generated by CBH.

scholarly journals Characterizing the Role of Brain Derived Neurotrophic Factor Genetic Variation in Alzheimer’s Disease Neurodegeneration

PLoS ONE ◽  
2013 ◽  
Vol 8 (9) ◽  
pp. e76001 ◽  
Author(s):  
Robyn A. Honea ◽  
Carlos Cruchaga ◽  
Rodrigo D. Perea ◽  
Andrew J. Saykin ◽  
Jeffrey M. Burns ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Genetic Variation ◽  
Neurotrophic Factor ◽  
Brain Derived Neurotrophic Factor
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