Role of ASK1/p38 Cascade in a Mouse Model of Alzheimer’s Disease and Brain Aging

2017 ◽  
Vol 61 (1) ◽  
pp. 259-263 ◽  
Author(s):  
Yu Hasegawa ◽  
Kensuke Toyama ◽  
Ken Uekawa ◽  
Hidenori Ichijo ◽  
Shokei Kim-Mitsuyama
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Brain Aging ◽  
Model Of Alzheimer’S Disease

O2-11-02: THE ROLE OF SOLUBLE TNF IN METABOLIC DYSFUNCTION AND BBB ALTERATIONS IN A MOUSE MODEL OF ALZHEIMER'S DISEASE

2006 ◽  
Vol 14 (7S_Part_12) ◽  
pp. P647-P647
Author(s):  
Malu G. Tansey ◽  
Kathryn P. MacPherson ◽  
Lori N. Eidson ◽  
Mary K. Herrick ◽  
Maria Elizabeth de Sousa Rodrigues ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Metabolic Dysfunction ◽  
Model Of Alzheimer’S Disease

Vasoactive effects of Aβin isolated human cerebrovessels and in a transgenic mouse model of Alzheimer's disease: Role of inflammation

2003 ◽  
Vol 25 (6) ◽  
pp. 642-651 ◽  
Author(s):  
Daniel Paris ◽  
James Humphrey ◽  
Amita Quadros ◽  
Nikunj Patel ◽  
Robert Crescentini ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Transgenic Mouse ◽  
Transgenic Mouse Model ◽  
Model Of Alzheimer’S Disease

scholarly journals Role of Lipocalin-2 in Amyloid-Beta Oligomer-Induced Mouse Model of Alzheimer’s Disease

Antioxidants ◽  
2021 ◽  
Vol 10 (11) ◽  
pp. 1657
Author(s):  
Heeyoung Kang ◽  
Hyun Joo Shin ◽  
Hyeong Seok An ◽  
Zhen Jin ◽  
Jong Youl Lee ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Amyloid Beta ◽  
Brain Injuries ◽  
Lipocalin 2 ◽  
Amyloid Toxicity ◽  
Blood Brain Barrier Disruption ◽  
Model Of Alzheimer’S Disease

Lipocalin-2 (LCN2) is an inflammatory protein with diverse functions in the brain. Although many studies have investigated the mechanism of LCN2 in brain injuries, the effect of LCN2 on amyloid-toxicity-related memory deficits in a mouse model of Alzheimer’s disease (AD) has been less studied. We investigated the role of LCN2 in human AD patients using a mouse model of AD. We created an AD mouse model by injecting amyloid-beta oligomer (AβO) into the hippocampus. In this model, animals exhibited impaired learning and memory. We found LCN2 upregulation in the human brain frontal lobe, as well as a positive correlation between white matter ischemic changes and serum LCN2. We also found increased astrocytic LCN2, microglia activation, iron accumulation, and blood–brain barrier disruption in AβO-treated hippocampi. These findings suggest that LCN2 is involved in a variety of amyloid toxicity mechanisms, especially neuroinflammation and oxidative stress.

[P2-090]: ROLE OF SOLUBLE TNF IN DIET-INDUCED PERIPHERAL AND CENTRAL INFLAMMATION IN A MOUSE MODEL OF ALZHEIMER's DISEASE

2017 ◽  
Vol 13 (7S_Part_13) ◽  
pp. P641-P641
Author(s):  
Malu G. Tansey ◽  
Kathryn P. MacPherson ◽  
Lori N. Eidson ◽  
Mary K. Herrick ◽  
Maria Elizabeth de Sousa Rodrigues ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease

Beneficial role of regulatory T cells in a mouse model of Alzheimer's disease

2014 ◽  
Vol 275 (1-2) ◽  
pp. 124 ◽  
Author(s):  
Cira Dansokho ◽  
Dylla Ait Ahmed ◽  
Cécile Toly-ndour ◽  
Saba Aid ◽  
Thomas Chaigneau ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
T Cells ◽  
Regulatory T Cells ◽  
Mouse Model ◽  
Beneficial Role ◽  
Model Of Alzheimer’S Disease

scholarly journals Neuroprotective role of γ‐enolase in microglia in a mouse model of Alzheimer's disease is regulated by cathepsin X

Aging Cell ◽  
2013 ◽  
Vol 12 (4) ◽  
pp. 604-614 ◽  
Author(s):  
Anja Hafner ◽  
Gordana Glavan ◽  
Nataša Obermajer ◽  
Marko Živin ◽  
Reinhard Schliebs ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Mouse Model ◽  
Model Of Alzheimer’S Disease ◽  
Cathepsin X
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