Rapid iterative negative geotaxis (RING): a new method for assessing age-related locomotor decline in

2005 ◽  
Vol 40 (5) ◽  
pp. 386-395 ◽  
Author(s):  
J GARGANO ◽  
I MARTIN ◽  
P BHANDARI ◽  
M GROTEWIEL
Keyword(s):  
New Method ◽  
Negative Geotaxis ◽  
Age Related

Quality of Vision Index: A New Method to Appraise Visual Function Changes in Age-Related Macular Degeneration

2011 ◽  
Vol 21 (1) ◽  
pp. 55-66 ◽  
Author(s):  
Stefano Piermarocchi ◽  
Monica Varano ◽  
Mahachstina Parravano ◽  
Francesco Oddone ◽  
Mauro Sartore ◽  
...  
Keyword(s):  
Macular Degeneration ◽  
Visual Function ◽  
Age Related Macular Degeneration ◽  
New Method ◽  
Age Related ◽  
Quality Of Vision

New method of salvage retinoblastoma treatment

2021 ◽  
pp. 215-220
Author(s):  
N.F. Bobrova ◽  
◽  
T.A. Sorochinskaya ◽  
S.A. Tronina ◽  
A.Y. Bratishko ◽  
...  
Keyword(s):  
Injection Site ◽  
Salvage Treatment ◽  
New Method ◽  
Simultaneous Action ◽  
Tissue Therapy ◽  
Age Related ◽  
Antibiotic Solution ◽  
One Step ◽  
Key Words Retinoblastoma ◽  
Pars Plana

Purpose. Elaboration of the new method of salvage retinoblastoma (RB) treatment, combining local and systemic chemotherapy. Material and methods. Salvage treatment using the new method was carried out in 71 children aged 2 months – 7 years on 102 eyes with RB in T1–T3 stages. At the Department of Pediatric Ophthalmopathology of SI «The Filatov Institute of Eye Diseases and Tissue Therapy of NAMS of Ukraine» the method of combined polychemotherapy (CPCT) was developed in 2010: primary IViC – injection of 0,01 µg (0,1 µg) Melphalan through pars plana; a course of CEV-protocol (drugs combination: Carboplatin + Etoposide Phosphate + Vincristine Sulfate) chemoreduction the next day after injection; monitoring the state of the tumor with repeated courses of SPHT every 3 weeks; addition of CPCT by focal destruction methods according to indications. In order to increase the ablasticity of IVi injections, we have developed the antireflux method of their implementation: to reduce IOP the diuretic injection is preliminarily performed in age-related dosage; puncture of the conjunctiva at the distance of 1–1,5 mm from the intended sclera puncture and its displacement above the IVi injection site; puncture of the sclera with obliquely perpendicular injection channel formation; IViC by cytostatic Melphalan in a volume of 0,1 ml in various dilutions depending on the indications; in repeated IViC – in different meridians; removing the needle with one-step tamponade of the injection site by cotton swab, antibiotic solution injecting under the conjunctiva with roller formation. Results. Ten-year experience of using the developed algorithm of salvage RB treatment by combined polychemotherapy, based on primary intravitreal melphalan chemotherapy (using the proposed antireflux injection method) with simultaneous systemic chemoreduction, proves its safety and effectivity – 77.5% regression of the tumors. Conclusion. Simultaneous action on the tumor of various cytostatics – one (melphalan) intraocular directly on the tumor and its vitreal clones, others – (carboplatin, etoposide, vincristine) – from the peripheral blood – creates the effect of «double blow» on RB cells. Key words: retinoblastoma, salvage treatment, combined polychemotherapy.

A New Method of Stair Markings for Visually Impaired People

1988 ◽  
Vol 82 (1) ◽  
pp. 24-27
Author(s):  
L. Sakamoto ◽  
E.B. Mehr
Keyword(s):  
Visually Impaired ◽  
The Other ◽  
New Method ◽  
Elderly Persons ◽  
Visually Impaired People ◽  
Age Related ◽  
Impaired People ◽  
Cataract Development ◽  
Group 2 ◽  
Group 1

Falls on stairs are a major hazard for elderly persons who are visually impaired. Stair marking is critical in making travel on stairs safe. Two groups of subjects with distinctly different visual impairments—group 1 having cataracts with healthy maculas; group 2 having age-related maculopathy with very little or no cataract development—were assessed to determine preference between two methods of marking stairways. Subjects were exposed to two identical stairways, one marked with traditional horizontal contrasting stripes, the other with a new method of three vertical stripes. Findings show that the newer method was preferred, with group 2 having a higher preference rate than group 1.

scholarly journals TECHNIQUE FOR DETERMINATION OF THE BIOLOGICAL AGE WITHIN THE FRAMEWORK OF THE FUNDAMENTAL CHARACTERISTICS OF AGING

2019 ◽  
Vol 63 (1) ◽  
pp. 22-28
Author(s):  
Anna V. Skrebneva ◽  
V. I. Popov ◽  
A. S. Buslova
Keyword(s):  
National Sample ◽  
The Body ◽  
Biological Age ◽  
New Method ◽  
Linear Regression Method ◽  
Medical Monitoring ◽  
Data Set ◽  
Age Related ◽  
Diagnostic Center ◽  
Improved Accuracy

The article describes a new method for determining the biological age (BV) of a person, developed by a team of authors: A. Skrebneva, V. Popov, A. Buslova. The goal and objectives are to develop a new method for assessing BV with determining its validity and usefulness for predicting the rate of aging in the framework of a large national sample of people. Material and methods. For the work, anonymous results of blood tests of patients from 2014 to 2016 were taken from the laboratory of the Voronezh Regional Clinical Consultative and Diagnostic Center, Russia. At the first stage, data was divided into two sets: the first included the parameters of healthypatients, the second set was consisted from patients who had abnormal results.Afterwards significant for prediction biomarkers were determined by methods of statistical analysis on the initial data set of healthy patients. At the second stage, a statistical model was built. When calendar age (CA) were considered unknown, it was calculated by Klemera and Doubal method. Results. The proposed method provides improved accuracy of determining BV compared to traditional methods based on the linear regression method, since it takes into account the complexity of the relationship between biomarkers and the change in the degree of influence of various biomarkers in the process of age-related changes in the body. This made it possible, with a known CV, to reduce the confidence interval in determining BV ± 10 years to ± 4 years, and with an unknown CV of the patient - from ± 25 years to ± 10.9 years. Discussion. The proposed method allows to increase the accuracy of determining BV is not less than 2.29 times. Conclusion. The proposed method allows to assess the degree of influence of adverse environmental factors, chronic diseases on life expectancy and the effectiveness of recreational physical culture for dynamic medical monitoring in various medical institutions.

Selective Sampling and Orientation of Non-Homogeneous Tissues

1968 ◽  
Vol 26 ◽  
pp. 98-99
Author(s):  
C. C. Clawson ◽  
L. W. Anderson ◽  
R. A. Good
Keyword(s):  
Electron Microscopy ◽  
Electron Microscope ◽  
Light Microscopy ◽  
Random Sampling ◽  
New Method ◽  
Microscope Examination ◽  
Small Areas ◽  
Selective Sampling ◽  
Large Numbers ◽  
Specific Orientation

Investigations which require electron microscope examination of a few specific areas of non-homogeneous tissues make random sampling of small blocks an inefficient and unrewarding procedure. Therefore, several investigators have devised methods which allow obtaining sample blocks for electron microscopy from region of tissue previously identified by light microscopy of present here techniques which make possible: 1) sampling tissue for electron microscopy from selected areas previously identified by light microscopy of relatively large pieces of tissue; 2) dehydration and embedding large numbers of individually identified blocks while keeping each one separate; 3) a new method of maintaining specific orientation of blocks during embedding; 4) special light microscopic staining or fluorescent procedures and electron microscopy on immediately adjacent small areas of tissue.

Spindle shaped bodies in foveolar cones of the baboon retina

1989 ◽  
Vol 47 ◽  
pp. 960-961
Author(s):  
W. Krebs ◽  
I. Krebs
Keyword(s):  
Cross Sections ◽  
Inclusion Bodies ◽  
Photoreceptor Cells ◽  
Papio Anubis ◽  
Retinal Photoreceptor ◽  
Age Related ◽  
Cone Cells ◽  
Membrane Bound ◽  
Oriented Parallel ◽  
Shaped Inclusion

Various inclusion bodies occur in vertebrate retinal photoreceptor cells. Most of them are membrane bound and associated with phagocytosis or they are age related residual bodies. We found an additional inclusion body in foveal cone cells of the baboon (Papio anubis) retina.The eyes of a 15 year old baboon were fixed by immersion in cacodylate buffered glutaraldehyde (2%)/formaldehyde (2%) as described in detail elsewhere . Pieces of retina from various locations, including the fovea, were embedded in epoxy resin such that radial or tangential sections could be cut.Spindle shaped inclusion bodies were found in the cytoplasm of only foveal cones. They were abundant in the inner segments, close to the external limiting membrane (Fig. 1). But they also occurred in the outer fibers, the perikarya, and the inner fibers (Henle’s fibers) of the cone cells. The bodies were between 0.5 and 2 μm long. Their central diameter was 0.2 to 0. 3 μm. They always were oriented parallel to the long axis of the cone cells. In longitudinal sections (Figs. 2,3) they seemed to have a fibrous skeleton that, in cross sections, turned out to consist of plate-like (Fig.4) and tubular profiles (Fig. 5).

Sign in / Sign up

Export Citation Format

Share Document