scholarly journals Time-dependent transcriptomic responses of Daphnia magna exposed to metabolic disruptors that enhanced storage lipid accumulation.

2019 ◽  
Vol 249 ◽  
pp. 99-108 ◽  
Author(s):  
Inmaculada Fuertes ◽  
Rita Jordão ◽  
Benjamín Piña ◽  
Carlos Barata
Keyword(s):  
Daphnia Magna ◽  
Lipid Accumulation ◽  
Time Dependent ◽  
Storage Lipid ◽  
Transcriptomic Responses

scholarly journals Mechanisms of Action of Compounds That Enhance Storage Lipid Accumulation in Daphnia magna

2016 ◽  
Vol 50 (24) ◽  
pp. 13565-13573 ◽  
Author(s):  
Rita Jordão ◽  
Bruno Campos ◽  
Benjamín Piña ◽  
Romà Tauler ◽  
Amadeu M. V. M. Soares ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Lipid Accumulation ◽  
Mechanisms Of Action ◽  
Storage Lipid

Storage lipid accumulation and acyltransferase action in developing flaxseed

Lipids ◽  
2005 ◽  
Vol 40 (10) ◽  
pp. 1043-1049 ◽  
Author(s):  
Brent M. Sørensen ◽  
Tara L. Furukawa-Stoffer ◽  
Kris S. Marshall ◽  
Erin K. Page ◽  
Zahir Mir ◽  
...  
Keyword(s):  
Lipid Accumulation ◽  
Storage Lipid

scholarly journals Mono(2-ethylhexyl) Phthalate Modulates the Lipid Accumulation and Reproductive Signaling in Daphnia Magna

2021 ◽  
Author(s):  
Hyunki Cho ◽  
Yohan Seol ◽  
Seungyun Baik ◽  
Baeckkyoung Sung ◽  
Chang Seon Ryu ◽  
...  
Keyword(s):  
Daphnia Magna ◽  
Exposure Time ◽  
Lipid Accumulation ◽  
Aquatic Organisms ◽  
Treated Group ◽  
Ecdysone Receptor ◽  
Female Adult ◽  
Primary Metabolite ◽  
Lipid Metabolites ◽  
Ethylhexyl Phthalate

Abstract Mono(2-ethylhexyl)-phthalate (MEHP) is the primary metabolite of di(2-ethylhexyl)-phthalate (DEHP), which is widely used in industry as a plasticizer. Previous studies showed that both DEHP and MEHP have been found in not only human urine samples but also natural aquatic environments, and well documented as toxicants for reproduction and endocrine disruptors, However, the effects of MEHP exposure on aquatic organisms, including invertebrates such as Daphnia magna (D. magna), are still scarce. In the present study, the lipid alterations caused by MEHP in D. magna have been identified by analyzing lipid accumulation and nontarget metabolomics. Additionally, the expressions of reproduction were investigated. Ecotoxicologically relevant concentrations (1 to 2 mg/L) and exposure time ranges (24 h to 21 days) have been tested. MEHP resulted in no mortality to D. magna with all exposure conditions, but the number of lipid droplets increased after 96 h of exposure and enhanced reproduction of female adult daphnids was observed in the 21-day of exposure. Besides, we observed that MEHP enhanced lipid metabolism with the identification of 283 potential lipid metabolites, including glycerolipids, glycerophospholipids, and sphingolipids, following 48 h of exposure. MEHP treated group exhibited significantly higher expression of ecdysone receptor (EcR) and vitellogenin 2 (Vtg2) at 6 h and 24 h. Meanwhile at 48 h, EcR and Vtg2 were downregulated in 1 and 2 mg/L MEHP exposure. Our data show that the changes in EcR pathway with different exposure time could be associated with the lipid accumulation due to lipids increment subsequently to increased reproduction in MEHP-exposed D. magna.

scholarly journals High-Fat Feeding in Time-Dependent Manner Affects Metabolic Routes Leading to Nervonic Acid Synthesis in NAFLD

2019 ◽  
Vol 20 (15) ◽  
pp. 3829 ◽  
Author(s):  
Konstantynowicz-Nowicka ◽  
Berk ◽  
Chabowski ◽  
Kasacka ◽  
Bielawiec ◽  
...  
Keyword(s):  
Fatty Acid Composition ◽  
Fatty Acid ◽  
Acid Composition ◽  
Lipid Accumulation ◽  
Time Dependent ◽  
Nervonic Acid ◽  
Dependent Manner ◽  
High Fat ◽  
Lipid Fractions ◽  
Fat Feeding

Nonalcoholic fatty liver disease (NAFLD) is characterized by excessive lipid accumulation in the liver. The disturbances in the fatty acid composition of stored lipids are more important than the lipid species itself, which may influence the overall effect caused by these molecules. Thus, uncovering time-dependent changes in the fatty acid composition of accumulated lipid fractions after a high fat diet seems to be a new marker of NAFLD occurrence. The experiments were conducted on high fat fed Wistar rats. The blood and liver samples were collected at the end of each experimental week and used to assess the content of lipid fractions and their fatty acid composition by gas liquid chromatography. The expression of proteins from lipid metabolism pathways and of fatty acid exporting proteins were detected by Western blotting. In the same high fat feeding period, decreased de novo lipogenesis, increased β-oxidation and lipid efflux were demonstrated. The observed effects may be the first liver protective mechanisms against lipotoxicity. Nevertheless, such effects were still not sufficient to prevent the liver from proinflammatory lipid accumulation. Moreover, the changes in liver metabolic pathways caused the plasma nervonic acid concentration in sphingomyelin to decrease simultaneously with NAFLD development, which may be a steatosis occurrence prognostic marker.

scholarly journals Effects of Single and Combined Low Concentrations of Neuroactive Drugs on Daphnia magna Reproduction and Transcriptomic Responses

2019 ◽  
Vol 53 (20) ◽  
pp. 11979-11987 ◽  
Author(s):  
Inmaculada Fuertes ◽  
Bruno Campos ◽  
Claudia Rivetti ◽  
Benjamín Piña ◽  
Carlos Barata
Keyword(s):  
Daphnia Magna ◽  
Low Concentrations ◽  
Neuroactive Drugs ◽  
Transcriptomic Responses

Time-Dependent Toxicity Responses in Daphnia magna Exposed to CuO and ZnO Nanoparticles

2017 ◽  
Vol 98 (4) ◽  
pp. 502-507 ◽  
Author(s):  
Soyoun Kim ◽  
Palas Samanta ◽  
Jisu Yoo ◽  
Woo-Keun Kim ◽  
Jinho Jung
Keyword(s):  
Daphnia Magna ◽  
Zno Nanoparticles ◽  
Time Dependent
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