Long lasting effects of prenatal exposure to deltamethrin on cerebral and hepatic cytochrome P450s and behavioral activity in rat offspring

2006 ◽  
Vol 544 (1-3) ◽  
pp. 58-68 ◽  
Author(s):  
Ashu Johri ◽  
Sanjay Yadav ◽  
Ram L. Singh ◽  
Alok Dhawan ◽  
Mohd. Ali ◽  
...  
Keyword(s):  
Prenatal Exposure ◽  
Cytochrome P450s ◽  
Behavioral Activity ◽  
Rat Offspring ◽  
Hepatic Cytochrome

scholarly journals Long-Lasting Alterations in Gene Expression of Postsynaptic Density 95 and Inotropic Glutamatergic Receptor Subunit in the Mesocorticolimbic System of Rat Offspring Born to Morphine-Addicted Mothers

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Pei-Ling Wu ◽  
Yung-Ning Yang ◽  
Jau-Ling Suen ◽  
Yu-Chen S. H. Yang ◽  
Chun-Hwa Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Glutamate Receptor ◽  
Ampa Receptor ◽  
Prenatal Exposure ◽  
Molecular Mechanisms ◽  
Postsynaptic Density ◽  
Receptor Subunit ◽  
Rat Offspring ◽  
Ampa Receptor Subunit

Prenatal exposure to morphine causes altered glutamatergic neurotransmission, which plays an important pathophysiological role for neurobiological basis of opiate-mediated behaviors in such offspring. However, it is still not clear whether such alteration involves gene expression of ionotropic glutamate receptor subunits. In this study, we further studied whether prenatal morphine exposure resulted in long-term changes in the gene expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, N-methyl-d-aspartate (NMDA) receptor, and postsynaptic density 95 in the mesocorticolimbic area (an essential integration circuitry for drug craving behavior), nucleus accumbens (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC), of rat offspring from morphine-addicted mothers. Experimental results showed that prenatal morphine exposure led to a persistent downregulation of gene expression in the AMPA and NMDA receptor subunit, with a differential manner of decreased magnitudes, at the age of postnatal days 14 (P14) and P30. However, in PFC, the gene expression of the AMPA receptor subunit was not synchronized in observed rat offspring subjected to prenatal morphine exposure. An upregulation of gene expression in the AMPA receptor subunit 3 (GluR3) was persistently observed at P14 and P30. Furthermore, the gene expressions of PSD-95 in NAc, VTA, and PFC were all decreased concurrently. Collectively, the results suggest that prenatal exposure to morphine may initiate molecular mechanisms leading to a long-lasting, differential alteration in gene expression of the inotropic glutamate receptor subunit and PSD-95 in the mesocorticolimbic circuitry in rat offspring. This study raises a possibility in which differential changes in gene expression with a long-lasting manner may play a role for the development of nearly permanent changes in opiate-mediated behaviors, at least in part for the neurobiological pathogenesis in offspring.

Prenatal exposure to MAM forms basis for persistent neural impairment in young and adult rat offspring

2012 ◽  
Vol 34 (2) ◽  
pp. 153-154
Author(s):  
Didima De Groot ◽  
Jan Lammers ◽  
Ine Waalkens ◽  
Donald Fox
Keyword(s):  
Prenatal Exposure ◽  
Adult Rat ◽  
Rat Offspring ◽  
Neural Impairment

scholarly journals The role of hepatic cytochrome P450s in the cytotoxicity of sertraline

2020 ◽  
Vol 94 (7) ◽  
pp. 2401-2411 ◽  
Author(s):  
Si Chen ◽  
Qiangen Wu ◽  
Xilin Li ◽  
Dongying Li ◽  
Michelle Fan ◽  
...  
Keyword(s):  
Cytochrome P450s ◽  
Hepatic Cytochrome

Prenatal exposure to glucocorticoids affects body weight, serum leptin levels, and hypothalamic neuropeptide‐Y expression in pre‐pubertal female rat offspring

2014 ◽  
Vol 36 (1) ◽  
pp. 1-4 ◽  
Author(s):  
Takeshi Iwasa ◽  
Toshiya Matsuzaki ◽  
Munkhsaikhan Munkhzaya ◽  
Altankhuu Tungalagsuvd ◽  
Takako Kawami ◽  
...  
Keyword(s):  
Body Weight ◽  
Neuropeptide Y ◽  
Prenatal Exposure ◽  
Female Rat ◽  
Serum Leptin ◽  
Rat Offspring
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