Prenatal exposure to MAM forms basis for persistent neural impairment in young and adult rat offspring

2012 ◽  
Vol 34 (2) ◽  
pp. 153-154
Author(s):  
Didima De Groot ◽  
Jan Lammers ◽  
Ine Waalkens ◽  
Donald Fox
Keyword(s):  
Prenatal Exposure ◽  
Adult Rat ◽  
Rat Offspring ◽  
Neural Impairment

Prenatal exposure to diazepam alters central and peripheral responses to stress in adult rat offspring

1984 ◽  
Vol 307 (1-2) ◽  
pp. 39-46 ◽  
Author(s):  
R.D. Simmons ◽  
R.K. Miller ◽  
C.K. Kellogg
Keyword(s):  
Prenatal Exposure ◽  
Adult Rat ◽  
Rat Offspring

scholarly journals Prenatal Exposure to IL-1β Results in Disturbed Skeletal Growth in Adult Rat Offspring

2004 ◽  
Vol 55 (4) ◽  
pp. 598-603 ◽  
Author(s):  
Diana Swolin-Eide ◽  
Cecilia Nilsson ◽  
Agneta Holmäng ◽  
Claes Ohlsson
Keyword(s):  
Prenatal Exposure ◽  
Skeletal Growth ◽  
Adult Rat ◽  
Rat Offspring

Breastfeeding undernutrition changes iBAT-involved thermogenesis protein expression and leads to a lean phenotype in adult rat offspring

2021 ◽  
pp. 108857
Author(s):  
Ginislene Dias Souza Miranda ◽  
Thalyne Aparecida Leite de Lima ◽  
Hercules de Oliveira Costermani ◽  
Camila Luiza Rodrigues dos Santos Ricken ◽  
Jocemara Patrícia Silva de Souza Parrela ◽  
...  
Keyword(s):  
Protein Expression ◽  
Adult Rat ◽  
Rat Offspring

The effects of prenatal “psychological” stressor exposure on lung inflammation and hyperresponsiveness in adult rat offspring

2016 ◽  
Vol 58 (8) ◽  
pp. 1076-1086 ◽  
Author(s):  
Maria Beatriz Barreto do Carmo ◽  
Renato Fraga Righetti ◽  
Iolanda de Fátima Lopes Calvo Tibério ◽  
Maria Helena Leite Hunziker
Keyword(s):  
Lung Inflammation ◽  
Adult Rat ◽  
Rat Offspring ◽  
Psychological Stressor

scholarly journals Long-Lasting Alterations in Gene Expression of Postsynaptic Density 95 and Inotropic Glutamatergic Receptor Subunit in the Mesocorticolimbic System of Rat Offspring Born to Morphine-Addicted Mothers

2018 ◽  
Vol 2018 ◽  
pp. 1-9 ◽  
Author(s):  
Pei-Ling Wu ◽  
Yung-Ning Yang ◽  
Jau-Ling Suen ◽  
Yu-Chen S. H. Yang ◽  
Chun-Hwa Yang ◽  
...  
Keyword(s):  
Gene Expression ◽  
Nmda Receptor ◽  
Glutamate Receptor ◽  
Ampa Receptor ◽  
Prenatal Exposure ◽  
Molecular Mechanisms ◽  
Postsynaptic Density ◽  
Receptor Subunit ◽  
Rat Offspring ◽  
Ampa Receptor Subunit

Prenatal exposure to morphine causes altered glutamatergic neurotransmission, which plays an important pathophysiological role for neurobiological basis of opiate-mediated behaviors in such offspring. However, it is still not clear whether such alteration involves gene expression of ionotropic glutamate receptor subunits. In this study, we further studied whether prenatal morphine exposure resulted in long-term changes in the gene expression of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor, N-methyl-d-aspartate (NMDA) receptor, and postsynaptic density 95 in the mesocorticolimbic area (an essential integration circuitry for drug craving behavior), nucleus accumbens (NAc), ventral tegmental area (VTA), and prefrontal cortex (PFC), of rat offspring from morphine-addicted mothers. Experimental results showed that prenatal morphine exposure led to a persistent downregulation of gene expression in the AMPA and NMDA receptor subunit, with a differential manner of decreased magnitudes, at the age of postnatal days 14 (P14) and P30. However, in PFC, the gene expression of the AMPA receptor subunit was not synchronized in observed rat offspring subjected to prenatal morphine exposure. An upregulation of gene expression in the AMPA receptor subunit 3 (GluR3) was persistently observed at P14 and P30. Furthermore, the gene expressions of PSD-95 in NAc, VTA, and PFC were all decreased concurrently. Collectively, the results suggest that prenatal exposure to morphine may initiate molecular mechanisms leading to a long-lasting, differential alteration in gene expression of the inotropic glutamate receptor subunit and PSD-95 in the mesocorticolimbic circuitry in rat offspring. This study raises a possibility in which differential changes in gene expression with a long-lasting manner may play a role for the development of nearly permanent changes in opiate-mediated behaviors, at least in part for the neurobiological pathogenesis in offspring.

Maternal high fat diet programs hypothalamic-pituitary-adrenal function in adult rat offspring

2019 ◽  
Vol 102 ◽  
pp. 128-138 ◽  
Author(s):  
XiaoTing Niu ◽  
XiaoYun Wu ◽  
AnNa Ying ◽  
Bei Shao ◽  
XiaoFeng Li ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Adrenal Function ◽  
High Fat ◽  
Hypothalamic Pituitary Adrenal ◽  
Adult Rat ◽  
Rat Offspring
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