Mesenchymal stromal cells isolated from human fetal liver release soluble factors with a potential role in liver tissue repair

2019 ◽  
Vol 105 ◽  
pp. 14-26 ◽  
Author(s):  
Cinzia Maria Chinnici ◽  
Giada Pietrosi ◽  
Gioacchin Iannolo ◽  
Giandomenico Amico ◽  
Nicola Cuscino ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Liver Tissue ◽  
Tissue Repair ◽  
Potential Role ◽  
Fetal Liver ◽  
Soluble Factors ◽  
Human Fetal Liver

Application of autologous multipotent mesenchymal stromal cells for correction of liver function in patients suffering from alcoholic liver cirrhosis

2020 ◽  
Vol 22 (4) ◽  
pp. 33-36
Author(s):  
I. E. Kotkas ◽  
V. I. Masurov ◽  
I. G. Bakulin ◽  
N. I. Enukashvili ◽  
Sh. M. Asadulayev
Keyword(s):  
Liver Cirrhosis ◽  
Liver Function ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Liver Tissue ◽  
Multipotent Mesenchymal Stromal Cells ◽  
Cirrhosis Of The Liver ◽  
Alternative Methods ◽  
Tissue Sampling ◽  
Satisfactory Condition

Clinical experience of application of autologous multipotent mesenchymal stromal cells in treatment of patient suffering from liver cirrhosis of alcoholic etiology is presented. A special feature is that the hepatocyte precursors were isolated directly from the patients liver tissue. The patient underwent laparoscopic surgery to obtain the largest volume of material and to be able to visually control the tissue sampling with minimal fibrotic changes. After liver tissue sampling, the patient was discharged for outpatient treatment in a satisfactory condition. Subsequently, the patient was re-admitted to the hospital. During repeated hospitalization, multipotent mesenchymal stromal cells in the amount of 20 million were injected into the arterial bed of the liver using x-ray endovascular technique. In the control study, 6 months after treatment, according to the 13C-metacetin test, normalization of liver function, regression of portal hypertension, and an increase in platelet levels were noted. There were no complications during this treatment. Treatment of patients suffering from cirrhosis of the liver is quite a serious and complex task. As a rule, the patient learns about his diagnosis already in the presence of complications, when the liver function is already significantly impaired. The propensity of the population to alcoholism leads to the formation of fibrosis, and subsequently cirrhosis of the liver. The absence of anti-fibrotic drugs contributes to the implementation of research to find alternative methods of treatment for this category of patients. In General, the use of autologous multipotent mesenchymal stromal cells is an effective and promising method, and research in this direction should be continued.

scholarly journals A Regulatory miRNA–mRNA Network Is Associated with Tissue Repair Induced by Mesenchymal Stromal Cells in Acute Kidney Injury

2017 ◽  
Vol 7 ◽  
Author(s):  
Danilo Candido de Almeida ◽  
Ênio Jose Bassi ◽  
Hatylas Azevedo ◽  
Letícia Anderson ◽  
Clarice Silvia Taemi Origassa ◽  
...  
Keyword(s):  
Acute Kidney Injury ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Kidney Injury

Mesenchymal stromal cells modulate tissue repair responses within the injured vocal fold

2019 ◽  
Vol 130 (1) ◽  
Author(s):  
Srinivasa Rao Nagubothu ◽  
Rachael V. Sugars ◽  
Nikolce Tudzarovski ◽  
Anton Törnqvist Andrén ◽  
Matteo Bottai ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Vocal Fold

scholarly journals Enhancing the Migration Ability of Mesenchymal Stromal Cells by Targeting the SDF-1/CXCR4 Axis

2013 ◽  
Vol 2013 ◽  
pp. 1-15 ◽  
Author(s):  
Leah A. Marquez-Curtis ◽  
Anna Janowska-Wieczorek
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Tissue Repair ◽  
Inflammatory Responses ◽  
Surface Expression ◽  
Trophic Factors ◽  
Migration Ability ◽  
Therapeutic Benefits

Mesenchymal stromal cells (MSCs) are currently being investigated in numerous clinical trials of tissue repair and various immunological disorders based on their ability to secrete trophic factors and to modulate inflammatory responses. MSCs have been shown to migrate to sites of injury and inflammation in response to soluble mediators including the chemokine stromal cell-derived factor-(SDF-)1, but during in vitro culture expansion MSCs lose surface expression of key homing receptors particularly of the SDF-1 receptor, CXCR4. Here we review studies on enhancement of SDF-1-directed migration of MSCs with the premise that their improved recruitment could translate to therapeutic benefits. We describe our studies on approaches to increase the CXCR4 expression in in vitro-expanded cord blood-derived MSCs, namely, transfection, using the commercial liposomal reagent IBAfect, chemical treatment with the histone deacetylase inhibitor valproic acid, and exposure to recombinant complement component C1q. These methodologies will be presented in the context of other cell targeting and delivery strategies that exploit pathways involved in MSC migration. Taken together, these findings indicate that MSCs can be manipulated in vitro to enhance their in vivo recruitment and efficacy for tissue repair.

scholarly journals Fetal liver-derived mesenchymal stromal cells augment engraftment of transplanted hepatocytes

Cytotherapy ◽  
2012 ◽  
Vol 14 (6) ◽  
pp. 657-669 ◽  
Author(s):  
Meghnad Joshi ◽  
Pradeep B. Patil ◽  
Zhong He ◽  
Jan Holgersson ◽  
Michael Olausson ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Fetal Liver

Mesenchymal stromal cells as multifunctional cellular therapeutics – a potential role for extracellular vesicles

2016 ◽  
Vol 55 (1) ◽  
pp. 62-69 ◽  
Author(s):  
Jillian Stephen ◽  
Elena Lopez Bravo ◽  
David Colligan ◽  
Alasdair R. Fraser ◽  
Juraj Petrik ◽  
...  
Keyword(s):  
Extracellular Vesicles ◽  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Potential Role ◽  
Cellular Therapeutics

Human hepatic stimulator substance: A product of gene expression of human fetal liver tissue

Hepatology ◽  
1993 ◽  
Vol 17 (2) ◽  
pp. 225-229 ◽  
Author(s):  
Fuchu He ◽  
Chutse Wu ◽  
Qiang Tu ◽  
Guichun Xing
Keyword(s):  
Gene Expression ◽  
Liver Tissue ◽  
Fetal Liver ◽  
Human Fetal Liver ◽  
Hepatic Stimulator Substance

DSP30 enhances the immunosuppressive properties of mesenchymal stromal cells and protects their suppressive potential from lipopolysaccharide effects: A potential role of adenosine

Cytotherapy ◽  
2016 ◽  
Vol 18 (7) ◽  
pp. 846-859 ◽  
Author(s):  
Bruno Sangiorgi ◽  
Helder Teixeira De Freitas ◽  
Josiane Lilian Dos Santos Schiavinato ◽  
Vitor Leão ◽  
Rodrigo Haddad ◽  
...  
Keyword(s):  
Mesenchymal Stromal Cells ◽  
Stromal Cells ◽  
Potential Role
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