scholarly journals Metabolic plasticity drives development during mammalian embryogenesis

2021 ◽  
Vol 56 (16) ◽  
pp. 2329-2347.e6 ◽  
Author(s):  
Mark S. Sharpley ◽  
Fangtao Chi ◽  
Johanna ten Hoeve ◽  
Utpal Banerjee
Keyword(s):  
Metabolic Plasticity ◽  
Mammalian Embryogenesis

Metabolic Plasticity of IDH1- Mutant Glioma Cell Lines Is Responsible for Low Sensitivity to Glutaminase Inhibition

2019 ◽  
Author(s):  
Victor Ruiz-Rodado ◽  
Adrian Lita ◽  
Tyrone Dowdy ◽  
Orieta Celiku ◽  
Alejandra Cavazos-Saldana ◽  
...  
Keyword(s):  
Cell Lines ◽  
Glioma Cell ◽  
Metabolic Plasticity ◽  
Glioma Cell Lines ◽  
Low Sensitivity

scholarly journals The metabolic profile of Bifidobacterium dentium reflects its status as a human gut commensal

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Melinda A. Engevik ◽  
Heather A. Danhof ◽  
Anne Hall ◽  
Kristen A. Engevik ◽  
Thomas D. Horvath ◽  
...  
Keyword(s):  
Gastrointestinal Tract ◽  
Metabolic Pathways ◽  
Glycosyl Hydrolase ◽  
Acid Resistance ◽  
Human Gut ◽  
Nutrient Sources ◽  
Metabolic Plasticity ◽  
Defined Media ◽  
High Viability ◽  
Ph Range

Abstract Background Bifidobacteria are commensal microbes of the mammalian gastrointestinal tract. In this study, we aimed to identify the intestinal colonization mechanisms and key metabolic pathways implemented by Bifidobacterium dentium. Results B. dentium displayed acid resistance, with high viability over a pH range from 4 to 7; findings that correlated to the expression of Na+/H+ antiporters within the B. dentium genome. B. dentium was found to adhere to human MUC2+ mucus and harbor mucin-binding proteins. Using microbial phenotyping microarrays and fully-defined media, we demonstrated that in the absence of glucose, B. dentium could metabolize a variety of nutrient sources. Many of these nutrient sources were plant-based, suggesting that B. dentium can consume dietary substances. In contrast to other bifidobacteria, B. dentium was largely unable to grow on compounds found in human mucus; a finding that was supported by its glycosyl hydrolase (GH) profile. Of the proteins identified in B. dentium by proteomic analysis, a large cohort of proteins were associated with diverse metabolic pathways, indicating metabolic plasticity which supports colonization of the dynamic gastrointestinal environment. Conclusions Taken together, we conclude that B. dentium is well adapted for commensalism in the gastrointestinal tract.

scholarly journals Plant Biostimulants from Cyanobacteria: An Emerging Strategy to Improve Yields and Sustainability in Agriculture

Plants ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 643
Author(s):  
Gaia Santini ◽  
Natascia Biondi ◽  
Liliana Rodolfi ◽  
Mario R. Tredici
Keyword(s):  
Nutrient Use Efficiency ◽  
Biologically Active ◽  
Future Research ◽  
Plant Tolerance ◽  
Metabolic Plasticity ◽  
Nutrient Use ◽  
Cyanobacterial Species ◽  
Use Efficiency ◽  
Promising Source ◽  
Plant Treatment

Cyanobacteria can be considered a promising source for the development of new biostimulants as they are known to produce a variety of biologically active molecules that can positively affect plant growth, nutrient use efficiency, qualitative traits of the final product, and increase plant tolerance to abiotic stresses. Moreover, the cultivation of cyanobacteria in controlled and confined systems, along with their metabolic plasticity, provides the possibility to improve and standardize composition and effects on plants of derived biostimulant extracts or hydrolysates, which is one of the most critical aspects in the production of commercial biostimulants. Faced with these opportunities, research on biostimulant properties of cyanobacteria has undergone a significant growth in recent years. However, research in this field is still scarce, especially as regards the number of investigated cyanobacterial species. Future research should focus on reducing the costs of cyanobacterial biomass production and plant treatment and on identifying the molecules that mediate the biostimulant effects in order to optimize their content and stability in the final product. Furthermore, the extension of agronomic trials to a wider number of plant species, different application doses, and environmental conditions would allow the development of tailored microbial biostimulants, thus facilitating the diffusion of these products among farmers.

scholarly journals Metabolic plasticity in the hygrophyte Moringa oleifera exposed to water stress

2018 ◽  
Author(s):  
Cecilia Brunetti ◽  
Francesco Loreto ◽  
Francesco Ferrini ◽  
Antonella Gori ◽  
Lucia Guidi ◽  
...  
Keyword(s):  
Water Stress ◽  
Moringa Oleifera ◽  
Metabolic Plasticity

scholarly journals Metabolic plasticity for subcutaneous fat accumulation in a long-distance migratory bird traced by2H2O

2017 ◽  
Vol 220 (6) ◽  
pp. 1072-1078 ◽  
Author(s):  
Ivan Viegas ◽  
Pedro M. Araújo ◽  
Afonso D. Rocha ◽  
Auxiliadora Villegas ◽  
John G. Jones ◽  
...  
Keyword(s):  
Subcutaneous Fat ◽  
Migratory Bird ◽  
Long Distance ◽  
Fat Accumulation ◽  
Metabolic Plasticity
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