scholarly journals Interkinetic Nuclear Migration Is a Broadly Conserved Feature of Cell Division in Pseudostratified Epithelia

2011 ◽  
Vol 21 (6) ◽  
pp. 485-491 ◽  
Author(s):  
Emily J. Meyer ◽  
Aissam Ikmi ◽  
Matthew C. Gibson
Keyword(s):  
Cell Division ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Interkinetic Nuclear Migration Is Centrosome Independent and Ensures Apical Cell Division to Maintain Tissue Integrity

2015 ◽  
Vol 32 (2) ◽  
pp. 203-219 ◽  
Author(s):  
Paulina J. Strzyz ◽  
Hyun O. Lee ◽  
Jaydeep Sidhaye ◽  
Isabell P. Weber ◽  
Louis C. Leung ◽  
...  
Keyword(s):  
Cell Division ◽  
Apical Cell ◽  
Nuclear Migration ◽  
Tissue Integrity ◽  
Interkinetic Nuclear Migration

Patterns of cell division and interkinetic nuclear migration in the chick embryo hindbrain

1991 ◽  
Vol 22 (7) ◽  
pp. 742-754 ◽  
Author(s):  
Sarah Guthrie ◽  
Matthew Butcher ◽  
Andrew Lumsden
Keyword(s):  
Cell Division ◽  
Chick Embryo ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

Interkinetic nuclear migration in the tracheal and esophageal epithelia of the mouse embryo: Possible implications for tracheo-esophageal anomalies

2017 ◽  
Vol 58 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Ryo Kaneda ◽  
Yuko Saeki ◽  
Dereje Getachew ◽  
Akihiro Matsumoto ◽  
Motohide Furuya ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Cephalopod Retinal Development Shows Vertebrate-like Mechanisms of Neurogenesis

2021 ◽  
Author(s):  
Francesca Napoli ◽  
Christina M Daly ◽  
Stephanie Neal ◽  
Kyle J McCulloch ◽  
Alexandra Zaloga ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Progenitor Cells ◽  
Cellular Proliferation ◽  
Imaging Techniques ◽  
Nuclear Migration ◽  
Live Imaging ◽  
Cellular Mechanisms ◽  
High Resolution Data ◽  
Interkinetic Nuclear Migration

Neurogenesis, the regulation of cellular proliferation and differentiation in the developing nervous system, is the process that underlies the diversity of size and cell type found in animal nervous systems. Our understanding of how this process has evolved is limited because of the lack of high resolution data and live-imaging methods across species. The retina is a classic model for the study of neurogenesis in vertebrates and live-imaging of the retina has shown that during development, progenitor cells are organized in a pseudostratified neuroepithelium and nuclei migrate in coordination with the cell cycle along the apicobasal axis of the cell, a process called interkinetic nuclear migration. Eventually cells delaminate and differentiate within the boundaries of the epithelium. This process has been considered unique to vertebrates and thought to be important in maintaining organization during the development of a complex nervous system. Coleoid cephalopods, including squid, cuttlefish and octopus, have the largest nervous system of any invertebrate and convergently-evolved camera-type eyes, making them a compelling comparative system to vertebrates. Here we have pioneered live-imaging techniques to show that the squid, Doryteuthis pealeii, displays cellular mechanisms during cephalopod retinal neurogenesis that are hallmarks of vertebrate processes. We find that retinal progenitor cells in the squid undergo interkinetic nuclear migration until they exit the cell cycle, we identify retinal organization corresponding to progenitor, post-mitotic and differentiated cells, and we find that Notch signaling regulates this process. With cephalopods and vertebrates having diverged 550 million years ago, these results suggest that mechanisms thought to be unique to vertebrates may be common to highly proliferative neurogenic primordia contributing to a large nervous system.

scholarly journals Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors

2010 ◽  
Vol 30 (12) ◽  
pp. 4197-4209 ◽  
Author(s):  
X. Liu ◽  
K. Hashimoto-Torii ◽  
M. Torii ◽  
C. Ding ◽  
P. Rakic
Keyword(s):  
Gap Junctions ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

Lis1, the Drosophila homolog of a human lissencephaly disease gene, is required for germline cell division and oocyte differentiation

Development ◽  
1999 ◽  
Vol 126 (20) ◽  
pp. 4477-4488 ◽  
Author(s):  
Z. Liu ◽  
T. Xie ◽  
R. Steward
Keyword(s):  
Cell Division ◽  
Neuronal Migration ◽  
Nuclear Migration ◽  
Germline Cell ◽  
Causal Gene ◽  
Membrane Cytoskeleton ◽  
Drosophila Homolog ◽  
Congenital Brain Malformation ◽  
Development Analysis ◽  
Oocyte Differentiation

Lissencephaly is a severe congenital brain malformation resulting from incomplete neuronal migration. One causal gene, LIS1, is homologous to nudF, a gene required for nuclear migration in A. nidulans. We have characterized the Drosophila homolog of LIS1 (Lis1) and show that Lis1 is essential for fly development. Analysis of ovarian Lis1 mutant clones demonstrates that Lis1 is required in the germline for synchronized germline cell division, fusome integrity and oocyte differentiation. Abnormal packaging of the cysts was observed in Lis1 mutant clones. Our results indicate that LIS1 is important for cell division and differentiation and the function of the membrane cytoskeleton. They support the notion that LIS1 functions with the dynein complex to regulate nuclear migration or cell migration.

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