scholarly journals Interkinetic nuclear migration, cell polarity, and retinal neurogenesis

2010 ◽  
Vol 7 (15) ◽  
pp. 30-30
Author(s):  
B. Link ◽  
S. Cui ◽  
L. Baye
Keyword(s):  
Cell Polarity ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration ◽  
Retinal Neurogenesis

scholarly journals Neural stem cell interkinetic nuclear migration is controlled by a phosphatidylinositol transfer protein/non-canonical planar cell polarity signaling axis

2020 ◽  
Author(s):  
Zhigang Xie ◽  
Vytas A. Bankaitis
Keyword(s):  
Cell Polarity ◽  
Membrane Trafficking ◽  
Planar Cell Polarity ◽  
Critical Role ◽  
Nuclear Migration ◽  
Transfer Protein ◽  
Interkinetic Nuclear Migration ◽  
Phosphatidylinositol Transfer Protein ◽  
Signaling Axis ◽  
Phosphatidylinositol Transfer

The mammalian neocortex undergoes explosive expansion during embryonic development. From an evolutionary perspective, higher complexity of the neocortex is accompanied by a prominent expansion in its lateral dimension so that the neocortical surface area is increased. Expansion in the radial dimension throughout evolution is limited so that neocortical thickness is strongly restricted1–3. The underlying mechanisms for restricting neocortical thickness remain unclear. Expansion of the developing mouse neocortex is driven by neurogenesis which is itself primarily fueled by neural stem cells (NSCs). NSCs form a pseudostratified epithelium and exhibit a hallmark cell cycle-dependent nuclear movement termed interkinetic nuclear migration (IKNM) 2–4. While IKNM plays a critical role in cell fate determination, it remains a poorly understood process. Herein, we demonstrate IKNM relies on a phosphatidylinositol transfer protein (PITP)-noncanonical planar cell polarity (ncPCP) signaling axis that restricts radial expansion of the developing neocortex. Ablation of PITPα/PITPβ in NSCs compromised IKNM -- resulting in a thickened neocortex and perturbed curvature of its ventricular surface. Those phenotypic derangements in IKNM and neocortical morphogenesis were recapitulated in mouse embryos individually ablated for two ncPCP receptor gene activities and in a mosaic neocortex expressing a dominant-negative variant of a third ncPCP receptor. Finally, PITP signaling links to ncPCP pathway activity by promoting membrane trafficking of a subset of ncPCP receptors from the trans-Golgi network to the NSC cell surface. We conclude IKNM is a driving force for a special form of convergent extension regulated by coupling PITP-mediated phosphoinositide signaling with activity of the evolutionarily conserved ncPCP pathway.

Interkinetic nuclear migration in the tracheal and esophageal epithelia of the mouse embryo: Possible implications for tracheo-esophageal anomalies

2017 ◽  
Vol 58 (2) ◽  
pp. 62-70 ◽  
Author(s):  
Ryo Kaneda ◽  
Yuko Saeki ◽  
Dereje Getachew ◽  
Akihiro Matsumoto ◽  
Motohide Furuya ◽  
...  
Keyword(s):  
Mouse Embryo ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Cephalopod Retinal Development Shows Vertebrate-like Mechanisms of Neurogenesis

2021 ◽  
Author(s):  
Francesca Napoli ◽  
Christina M Daly ◽  
Stephanie Neal ◽  
Kyle J McCulloch ◽  
Alexandra Zaloga ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nervous System ◽  
Progenitor Cells ◽  
Cellular Proliferation ◽  
Imaging Techniques ◽  
Nuclear Migration ◽  
Live Imaging ◽  
Cellular Mechanisms ◽  
High Resolution Data ◽  
Interkinetic Nuclear Migration

Neurogenesis, the regulation of cellular proliferation and differentiation in the developing nervous system, is the process that underlies the diversity of size and cell type found in animal nervous systems. Our understanding of how this process has evolved is limited because of the lack of high resolution data and live-imaging methods across species. The retina is a classic model for the study of neurogenesis in vertebrates and live-imaging of the retina has shown that during development, progenitor cells are organized in a pseudostratified neuroepithelium and nuclei migrate in coordination with the cell cycle along the apicobasal axis of the cell, a process called interkinetic nuclear migration. Eventually cells delaminate and differentiate within the boundaries of the epithelium. This process has been considered unique to vertebrates and thought to be important in maintaining organization during the development of a complex nervous system. Coleoid cephalopods, including squid, cuttlefish and octopus, have the largest nervous system of any invertebrate and convergently-evolved camera-type eyes, making them a compelling comparative system to vertebrates. Here we have pioneered live-imaging techniques to show that the squid, Doryteuthis pealeii, displays cellular mechanisms during cephalopod retinal neurogenesis that are hallmarks of vertebrate processes. We find that retinal progenitor cells in the squid undergo interkinetic nuclear migration until they exit the cell cycle, we identify retinal organization corresponding to progenitor, post-mitotic and differentiated cells, and we find that Notch signaling regulates this process. With cephalopods and vertebrates having diverged 550 million years ago, these results suggest that mechanisms thought to be unique to vertebrates may be common to highly proliferative neurogenic primordia contributing to a large nervous system.

scholarly journals Gap Junctions/Hemichannels Modulate Interkinetic Nuclear Migration in the Forebrain Precursors

2010 ◽  
Vol 30 (12) ◽  
pp. 4197-4209 ◽  
Author(s):  
X. Liu ◽  
K. Hashimoto-Torii ◽  
M. Torii ◽  
C. Ding ◽  
P. Rakic
Keyword(s):  
Gap Junctions ◽  
Nuclear Migration ◽  
Interkinetic Nuclear Migration

scholarly journals Regulation of interkinetic nuclear migration by cell cycle-coupled active and passive mechanisms in the developing brain

2011 ◽  
Vol 30 (9) ◽  
pp. 1690-1704 ◽  
Author(s):  
Yoichi Kosodo ◽  
Taeko Suetsugu ◽  
Masumi Suda ◽  
Yuko Mimori-Kiyosue ◽  
Kazunori Toida ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Nuclear Migration ◽  
Developing Brain ◽  
Interkinetic Nuclear Migration

Comprehensive analysis of the interkinetic nuclear migration in developing mouse brain

2009 ◽  
Vol 65 ◽  
pp. S55
Author(s):  
Yoichi Kosodo ◽  
Akatsuki Kimura ◽  
Taeko Suetsugu ◽  
Shoji Baba ◽  
Fumio Matsuzaki
Keyword(s):  
Mouse Brain ◽  
Nuclear Migration ◽  
Comprehensive Analysis ◽  
Interkinetic Nuclear Migration ◽  
Developing Mouse Brain
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