Oral administration of type-II collagen peptide 250–270 suppresses specific cellular and humoral immune response in collagen-induced arthritis

2007 ◽  
Vol 122 (1) ◽  
pp. 75-84 ◽  
Author(s):  
Ping Zhu ◽  
Xiao-Yan Li ◽  
Hong-Kun Wang ◽  
Jun-Feng Jia ◽  
Zhao-Hui Zheng ◽  
...  
Keyword(s):  
Immune Response ◽  
Oral Administration ◽  
Humoral Immune Response ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Humoral Immune ◽  
Collagen Peptide

Enhancing effects of tilorone on collagen arthritis and humoral immune response to type II collagen

1987 ◽  
Vol 42 (3) ◽  
pp. 311-318
Author(s):  
Nobuhiro Kaibara ◽  
Kenji Takagishi ◽  
Takao Hotokebuchi ◽  
Masahiro Morinaga ◽  
Chikafumi Arita ◽  
...  
Keyword(s):  
Immune Response ◽  
Humoral Immune Response ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Humoral Immune ◽  
Collagen Arthritis

scholarly journals Humoral immune response to citrullinated collagen type II determinants in early rheumatoid arthritis

2005 ◽  
Vol 35 (5) ◽  
pp. 1643-1652 ◽  
Author(s):  
Harald Burkhardt ◽  
Bettina Sehnert ◽  
Robert Bockermann ◽  
Åke Engström ◽  
Jochen R. Kalden ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Immune Response ◽  
Early Rheumatoid Arthritis ◽  
Humoral Immune Response ◽  
Collagen Type ◽  
Type Ii ◽  
Collagen Type Ii ◽  
Humoral Immune

Long-Term Oral Administration of Ginseng Extract Modulates Humoral Immune Response and Spleen Cell Functions

2005 ◽  
Vol 33 (04) ◽  
pp. 651-661 ◽  
Author(s):  
Chian-Jiun Liou ◽  
Wen-Chung Huang ◽  
Jerming Tseng
Keyword(s):  
Immune Response ◽  
Oral Administration ◽  
Spleen Cell ◽  
Humoral Immune Response ◽  
Ginseng Root ◽  
Spleen Cells ◽  
Ginseng Extract ◽  
Humoral Immune ◽  
Cell Functions

Ginseng radix (Panax ginseng C.A. Meyer) is a popular herbal medicine in Oriental countries. We investigated the effect of long-term oral administration of ginseng extract on the antigen-specific antibody response. Male BALB/c mice were treated orally for 30 consecutive days with 2 g/kg of a 50% ethanol extract of ginseng root. Mice treated with ginseng and immunized with ovalbumin (OVA), resulting in an eight-fold increase in titers of anti-OVA immunoglobulin (Ig)G in the serum compared to the group receiving OVA immunization without ginseng treatment; the level of IgG was also significantly elevated in the mice treated with ginseng and immunized with OVA. Mice treated with ginseng without OVA immunization exhibited significantly reduced IgG and IgA production by spleen cells. However, IgG production was not affected in mice treated with ginseng and OVA immunization in spleen cells. Interleukin (IL)-2, interferon (IFN)-γ and IL-4 secretion by spleen cells from either ginseng-treated mice or OVA-immunized mice were down-regulated compared to that in the control group; while the production of IL-10 was unchanged. The percentage of CD8+ cells was significantly reduced in spleen cells from ginseng-treated, OVA-immunized mice. Thus, long-term oral administration of ginseng extract appears to potentiate humoral immune response but suppress spleen cell functions.

Interleukin-1 potentiates the development of collagen-induced arthritis in mice

1989 ◽  
Vol 76 (5) ◽  
pp. 535-538 ◽  
Author(s):  
L. M. Killar ◽  
C. J. Dunn
Keyword(s):  
Immune Response ◽  
Interleukin 1 ◽  
Subcutaneous Administration ◽  
Type Ii Collagen ◽  
Interleukin 1Β ◽  
Type Ii ◽  
Collagen Induced Arthritis

1. The subcutaneous administration of recombinant human interleukin-1β (rhIL-1β) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1β had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.

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