scholarly journals Native type II collagen-induced arthritis in the rat. III. Relationship between the cellular immune response to native type II collagen and arthritis.

1983 ◽  
Vol 42 (3) ◽  
pp. 331-337 ◽  
Author(s):  
W A Ofosu-Appiah ◽  
K Morgan ◽  
P J Lennox Holt
Keyword(s):  
Immune Response ◽  
Cellular Immune Response ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
Cellular Immune

Interleukin-1 potentiates the development of collagen-induced arthritis in mice

1989 ◽  
Vol 76 (5) ◽  
pp. 535-538 ◽  
Author(s):  
L. M. Killar ◽  
C. J. Dunn
Keyword(s):  
Immune Response ◽  
Interleukin 1 ◽  
Subcutaneous Administration ◽  
Type Ii Collagen ◽  
Interleukin 1Β ◽  
Type Ii ◽  
Collagen Induced Arthritis

1. The subcutaneous administration of recombinant human interleukin-1β (rhIL-1β) was found to induce an increased incidence and earlier onset of collagen-induced arthritis in mice. 2. The rhIL-1β had different effects, depending on when it was administered after collagen-immunization. 3. The effect of rhIL-1β may be due, in part, to augmentation of the immune response to type II collagen. 4. Interleukin-1-accelerated, collagen-induced arthritis will provide a useful model for investigating the role of interleukin-1 in the regulation of arthritic diseases, and the development of anti-arthritic therapeutics.

scholarly journals The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

2020 ◽  
Author(s):  
xiangyang li ◽  
Ying Yang ◽  
Su-Ping Qin ◽  
Fan-Yun Kong ◽  
Chao Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Respiratory Exchange Ratio ◽  
Clonorchis Sinensis ◽  
Joint Inflammation ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Oral Gavage ◽  
Collagen Induced Arthritis ◽  
The Impact

Abstract Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4 + T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

scholarly journals The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

2019 ◽  
Author(s):  
xiangyang li ◽  
Ying Yang ◽  
Su-Ping Qin ◽  
Fan-Yun Kong ◽  
Chao Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Respiratory Exchange Ratio ◽  
Clonorchis Sinensis ◽  
Joint Inflammation ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Oral Gavage ◽  
Collagen Induced Arthritis ◽  
The Impact

Abstract Background Clonorchis sinensis infection could trigger strong immune responses in mice and human. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice.Results The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, the arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws were observed in type II collagen-induced arthritis (CIA) mice. In addition, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6C hi monocytes, decreased B cells and CD4+T cells were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significant higher levels of serum IL-4 and IL-17 than those in CIA mice. Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of immune response in mice with CIA.

scholarly journals The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

2020 ◽  
Author(s):  
xiangyang li ◽  
Ying Yang ◽  
Su-Ping Qin ◽  
Fan-Yun Kong ◽  
Chao Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Immune Responses ◽  
Respiratory Exchange Ratio ◽  
Clonorchis Sinensis ◽  
Joint Inflammation ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Oral Gavage ◽  
Collagen Induced Arthritis ◽  
The Impact

Abstract Background: Clonorchis sinensis infection could trigger strong immune responses in mice and humans. However, whether the C.sinensis infection has an impact on arthritis is unknown. Here we investigated the effect of C.sinensis infection on type II collagen-induced arthritis in BALB/c mice. Results: The mice were firstly infected with 45 C.sinensis metacercariae by oral gavage. Four weeks later, arthritis in mice was induced by type II collagen. Joint inflammation with severe redness and swelling in hind paws was observed in type II collagen-induced arthritis (CIA) mice. Besides, the physical activity was significantly reduced, but the respiratory exchange ratio was increased in CIA mice. Compared with CIA mice, C.sinensis infection could increase the severity of arthritis in CIA mice, based on the results of disease score and pathological changes. Compared to CIA mice, increased neutrophils and Ly6Chi monocytes, decreased B cells and CD4+T cells, were found in C.sinensis infected CIA mice. Besides these, C.sinensis infected mice also displayed significantly higher levels of serum IL-4 and IL-17 than those in CIA mice. Conclusions: Taken together, our data suggest that C.sinensis infection have a bad effect on arthritis, and could induce the abnormality of the immune response in mice with CIA.

scholarly journals The impact of Clonorchis sinensis infection on immune response in mice with type II collagen-induced arthritis

2020 ◽  
Vol 21 (1) ◽  
Author(s):  
Xiangyang Li ◽  
Ying Yang ◽  
Suping Qin ◽  
Fanyun Kong ◽  
Chao Yan ◽  
...  
Keyword(s):  
Immune Response ◽  
Clonorchis Sinensis ◽  
Type Ii Collagen ◽  
Type Ii ◽  
Collagen Induced Arthritis ◽  
The Impact
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