scholarly journals Ndfip Proteins Target Robo Receptors for Degradation and Allow Commissural Axons to Cross the Midline in the Developing Spinal Cord

Cell Reports ◽  
2019 ◽  
Vol 26 (12) ◽  
pp. 3298-3312.e4 ◽  
Author(s):  
Madhavi Gorla ◽  
Celine Santiago ◽  
Karina Chaudhari ◽  
Awo Akosua Kesewa Layman ◽  
Paula M. Oliver ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Commissural Axons ◽  
Robo Receptors ◽  
Developing Spinal Cord

scholarly journals Dorsal commissural axon guidance in the developing spinal cord

2020 ◽  
Author(s):  
Sandy Alvarez ◽  
Supraja G. Varadarajan ◽  
Samantha J. Butler
Keyword(s):  
Spinal Cord ◽  
Axon Guidance ◽  
Commissural Axon ◽  
Developing Spinal Cord

scholarly journals Expression and Cellular Distribution of Ubiquitin in Response to Injury in the Developing Spinal Cord of Monodelphis domestica

PLoS ONE ◽  
2013 ◽  
Vol 8 (4) ◽  
pp. e62120 ◽  
Author(s):  
Natassya M. Noor ◽  
Kjeld Møllgård ◽  
Benjamin J. Wheaton ◽  
David L. Steer ◽  
Jessie S. Truettner ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Monodelphis Domestica ◽  
Cellular Distribution ◽  
Developing Spinal Cord

Developmental expression of mouse stromelysin-3 mRNA

Development ◽  
1995 ◽  
Vol 121 (4) ◽  
pp. 947-955 ◽  
Author(s):  
O. Lefebvre ◽  
C. Regnier ◽  
M.P. Chenard ◽  
C. Wendling ◽  
P. Chambon ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Mesenchymal Cells ◽  
Developmental Expression ◽  
Spatiotemporal Pattern ◽  
Commissural Axons ◽  
Embryonic Tissues ◽  
Trophoblastic Cells ◽  
Neuroepithelial Cells ◽  
Stromelysin 3

We have used northern blot analysis and in situ hybridization to study the spatial distribution of stromelysin-3 (ST3) expression during mouse embryogenesis. ST3 mRNA was observed in trophoblastic cells at the site of embryonic implantation (7.5-8.5 days) and in a variety of developing embryonic tissues. In these tissues, the highest ST3 expression levels were observed during the development of the external features of limb, tail and snout, and during bone and spinal cord morphogenesis. In limb, tail and snout, ST3 expression was specifically detected in mesenchymal cells lining the basement membrane at the junction of primitive dermis and epidermis, and adjacent to epithelial cells undergoing proliferation and/or apoptosis. In bone, ST3 was expressed in invasive mesenchymal cells and, in the spinal cord in neuroepithelial cells of the floor plate, at the time that this structure is crossed by commissural axons. Altogether, these observations suggest a role for ST3 during embryonic morphogenesis, in tissue remodeling processes associated with cell proliferation, death and/or invasion. Moreover, when compared to urokinase and tissue plasminogen activators, the spatiotemporal pattern of ST3 expression shows some similarities, but was not completely superimposable, suggesting that these genes may cooperate in some developing tissues and have specific functions in others.

scholarly journals Minocycline attenuates ethanol-induced cell death and microglial activation in the developing spinal cord

Alcohol ◽  
2019 ◽  
Vol 79 ◽  
pp. 25-35 ◽  
Author(s):  
Zhenhua Ren ◽  
Xin Wang ◽  
Mei Xu ◽  
Jacqueline A. Frank ◽  
Jia Luo
Keyword(s):  
Spinal Cord ◽  
Cell Death ◽  
Microglial Activation ◽  
Developing Spinal Cord
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