scholarly journals TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

Cell Reports ◽  
2017 ◽  
Vol 20 (4) ◽  
pp. 973-983 ◽  
Author(s):  
Maryline Abrial ◽  
Noëlle Paffett-Lugassy ◽  
Spencer Jeffrey ◽  
Daniel Jordan ◽  
Evan O’Loughlin ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery ◽  
Necessary And Sufficient

scholarly journals Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis

Development ◽  
2019 ◽  
Vol 146 (18) ◽  
pp. dev177618 ◽  
Author(s):  
Helen M. Phillips ◽  
Catherine A. Stothard ◽  
Wasay M. Shaikh Qureshi ◽  
Anastasia I. Kousa ◽  
J. Alberto Briones-Leon ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Cardiovascular Development ◽  
Pharyngeal Endoderm ◽  
Pharyngeal Arch Artery

scholarly journals Clarification of the identity of the mammalian fifth pharyngeal arch artery

2012 ◽  
Vol 26 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Simon D. Bamforth ◽  
Bill Chaudhry ◽  
Michael Bennett ◽  
Robert Wilson ◽  
Timothy J. Mohun ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery

scholarly journals Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor

2016 ◽  
Vol 139 ◽  
pp. 65-73 ◽  
Author(s):  
Masahide Fujita ◽  
Masahide Sakabe ◽  
Tomoko Ioka ◽  
Yusuke Watanabe ◽  
Yumi Kinugasa-Katayama ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Aortic Arch ◽  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery

scholarly journals Transitory expression of Dlx5 and Dlx6 in maxillary arch precursors is essential for upper jaw morphogenesis

F1000Research ◽  
2013 ◽  
Vol 2 ◽  
pp. 261 ◽  
Author(s):  
Yorick Gitton ◽  
Nicolas Narboux-Nême ◽  
Giovanni Levi
Keyword(s):  
Distal Part ◽  
Pharyngeal Arch ◽  
Genetic Approach ◽  
Cranial Neural Crest Cells ◽  
Necessary And Sufficient ◽  
Maxillary Defects ◽  
Olfactory Pit ◽  
Combinatorial Expression ◽  
Maxillary Arch

Asymmetric, articulated jaws support active predation in vertebrates; they derive from the first pharyngeal arch (PA1) which generates both maxillary and mandibular components. PA1 is colonized by cranial neural crest cells (CNCCs) which give rise to most bones and tendons of the jaws. The elements formed by different CNCCs contingents are specified by the combinatorial expression of Dlx genes. Dlx5 and Dlx6 are predominantly expressed by mandibular CNCCs. Analysis of the phenotype of Dlx5 and Dlx6 double mutant mice has suggested that they are necessary and sufficient to specify mandibular identity. Here, using 3D reconstruction, we show that inactivation of Dlx5 and Dlx6 does not only affect the mandibular arch, but results in the simultaneous transformation of mandibular and maxillary skeletal elements which assume a similar morphology with gain of symmetry. As Dlx5- and Dlx6-expressing cells are not found in the maxillary bud, we have examined the lineage of Dlx5-expressing progenitors using an in vivo genetic approach. We find that a contingent of cells deriving from precursors transiently expressing Dlx5 participate in the formation of the maxillary arch. These cells are mostly located in the distal part of the maxillary arch and might derive from its lambdoidal junction with the olfactory pit. Our findings extend current models of jaw morphogenesis and provide an explanation for the maxillary defects of Dlx5 and Dlx6 mutants. Our results imply that Dlx5 and Dlx6 model the upper and the lower PA1 components through different morphogenetic mechanisms which are, however, coordinated as they give rise to functional, articulated jaws.

scholarly journals Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfβ2 knock-out mice

2002 ◽  
Vol 56 (2) ◽  
pp. 312-322 ◽  
Author(s):  
D MOLIN ◽  
M DERUITER ◽  
L WISSE ◽  
M AZHAR ◽  
T DOETSCHMAN ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Pharyngeal Arch ◽  
Knock Out ◽  
Pharyngeal Arch Artery ◽  
Knock Out Mice
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