scholarly journals Clarification of the identity of the mammalian fifth pharyngeal arch artery

2012 ◽  
Vol 26 (2) ◽  
pp. 173-182 ◽  
Author(s):  
Simon D. Bamforth ◽  
Bill Chaudhry ◽  
Michael Bennett ◽  
Robert Wilson ◽  
Timothy J. Mohun ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery

scholarly journals TGF-β Signaling Is Necessary and Sufficient for Pharyngeal Arch Artery Angioblast Formation

Cell Reports ◽  
2017 ◽  
Vol 20 (4) ◽  
pp. 973-983 ◽  
Author(s):  
Maryline Abrial ◽  
Noëlle Paffett-Lugassy ◽  
Spencer Jeffrey ◽  
Daniel Jordan ◽  
Evan O’Loughlin ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery ◽  
Necessary And Sufficient

scholarly journals Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis

Development ◽  
2019 ◽  
Vol 146 (18) ◽  
pp. dev177618 ◽  
Author(s):  
Helen M. Phillips ◽  
Catherine A. Stothard ◽  
Wasay M. Shaikh Qureshi ◽  
Anastasia I. Kousa ◽  
J. Alberto Briones-Leon ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Cardiovascular Development ◽  
Pharyngeal Endoderm ◽  
Pharyngeal Arch Artery

scholarly journals Pharyngeal arch artery defects and lethal malformations of the aortic arch and its branches in mice deficient for the Hrt1/Hey1 transcription factor

2016 ◽  
Vol 139 ◽  
pp. 65-73 ◽  
Author(s):  
Masahide Fujita ◽  
Masahide Sakabe ◽  
Tomoko Ioka ◽  
Yusuke Watanabe ◽  
Yumi Kinugasa-Katayama ◽  
...  
Keyword(s):  
Transcription Factor ◽  
Aortic Arch ◽  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery

scholarly journals Altered apoptosis pattern during pharyngeal arch artery remodelling is associated with aortic arch malformations in Tgfβ2 knock-out mice

2002 ◽  
Vol 56 (2) ◽  
pp. 312-322 ◽  
Author(s):  
D MOLIN ◽  
M DERUITER ◽  
L WISSE ◽  
M AZHAR ◽  
T DOETSCHMAN ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Pharyngeal Arch ◽  
Knock Out ◽  
Pharyngeal Arch Artery ◽  
Knock Out Mice

scholarly journals Pax9 is required for cardiovascular development and interacts with Tbx1 in the pharyngeal endoderm to control 4th pharyngeal arch artery morphogenesis

2019 ◽  
Author(s):  
Helen M. Phillips ◽  
Catherine A. Stothard ◽  
Wasay Mohiuddin Shaikh Qureshi ◽  
Anastasia I. Kousa ◽  
J. Alberto Briones-Leon ◽  
...  
Keyword(s):  
Aortic Arch ◽  
Genetic Interaction ◽  
Interrupted Aortic Arch ◽  
Outflow Tract ◽  
Pharyngeal Arch ◽  
Cardiovascular Development ◽  
Developmental Defects ◽  
Pharyngeal Endoderm ◽  
Pharyngeal Arch Artery ◽  
Aortic Arch Arteries

AbstractDevelopmental defects affecting the heart and aortic arch arteries are a key phenotype observed in DiGeorge syndrome patients and are caused by a microdeletion on chromosome 22q11. Heterozygosity of TBX1, one of the deleted genes, is expressed throughout the pharyngeal arches and is considered a key component for the arch artery defects. Pax9 is expressed in the pharyngeal endoderm and is downregulated in Tbx1 mutant mice. We show here that Pax9 deficient mice are born with complex cardiovascular malformations affecting the outflow tract and aortic arch arteries with failure of the 3rd and 4th pharyngeal arch arteries to form correctly. Transcriptome analysis indicated that Pax9 and Tbx1 may function together, and mice double heterozygous for Tbx1/Pax9 presented with a significantly increased incidence of interrupted aortic arch when compared to Tbx1 heterozygous mice. Using a novel Pax9Cre allele we demonstrated that the site of this Tbx1-Pax9 genetic interaction is in the pharyngeal endoderm, therefore revealing that a Tbx1/Pax9-controlled signalling mechanism emanating from the pharyngeal endoderm is required for critical tissue interactions during normal morphogenesis of the pharyngeal arch artery system.Summary statementPax9 is required for outflow tract and aortic arch development, and functions together with Tbx1 in the pharyngeal endoderm for 4th arch artery formation.

scholarly journals Hoxa1 and Hoxb1 are required for pharyngeal arch artery development

2017 ◽  
Vol 143 ◽  
pp. 1-8 ◽  
Author(s):  
Marine Roux ◽  
Brigitte Laforest ◽  
Nathalie Eudes ◽  
Nicolas Bertrand ◽  
Sonia Stefanovic ◽  
...  
Keyword(s):  
Pharyngeal Arch ◽  
Pharyngeal Arch Artery
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