Calcium-induced calcium release and gap junctions mediate large-scale calcium waves in olfactory ensheathing cells in situ

Cell Calcium ◽  
2015 ◽  
Vol 58 (2) ◽  
pp. 215-225 ◽  
Author(s):  
Maren Stavermann ◽  
Patrick Meuth ◽  
Michael Doengi ◽  
Anne Thyssen ◽  
Joachim W. Deitmer ◽  
...  
Keyword(s):  
Gap Junctions ◽  
Large Scale ◽  
Calcium Release ◽  
Olfactory Ensheathing Cells ◽  
Calcium Waves ◽  
Ensheathing Cells ◽  
Calcium Induced Calcium Release

Panglial gap junctions between astrocytes and olfactory ensheathing cells mediate transmission of Ca 2+ transients and neurovascular coupling

Glia ◽  
2019 ◽  
Vol 67 (7) ◽  
pp. 1385-1400 ◽  
Author(s):  
Antonia Beiersdorfer ◽  
Anja Scheller ◽  
Frank Kirchhoff ◽  
Christian Lohr
Keyword(s):  
Gap Junctions ◽  
Neurovascular Coupling ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

Endothelin uncouples gap junctions in sustentacular cells and olfactory ensheathing cells of the olfactory mucosa

2014 ◽  
Vol 40 (6) ◽  
pp. 2878-2887 ◽  
Author(s):  
Mikaël Le Bourhis ◽  
Stéphanie Rimbaud ◽  
Denise Grebert ◽  
Patrice Congar ◽  
Nicolas Meunier
Keyword(s):  
Gap Junctions ◽  
Olfactory Mucosa ◽  
Olfactory Ensheathing Cells ◽  
Sustentacular Cells ◽  
Ensheathing Cells

Cell surface expression of 27C7 by neonatal rat olfactory ensheathing cells in situ and in vitro is independent of axonal contact

2011 ◽  
Vol 135 (4) ◽  
pp. 397-408 ◽  
Author(s):  
Gudrun Brandes ◽  
Massoud Khayami ◽  
Claas-Tido Peck ◽  
Wolfgang Baumgärtner ◽  
Hatice Bugday ◽  
...  
Keyword(s):  
Cell Surface ◽  
Surface Expression ◽  
Neonatal Rat ◽  
Olfactory Ensheathing Cells ◽  
Cell Surface Expression ◽  
Ensheathing Cells

Differential expression of HNK-1 and p75NTR in adult canine Schwann cells and olfactory ensheathing cells in situ but not in vitro

2007 ◽  
Vol 505 (5) ◽  
pp. 572-585 ◽  
Author(s):  
Patricia Bock ◽  
Andreas Beineke ◽  
Somporn Techangamsuwan ◽  
Wolfgang Baumgärtner ◽  
Konstantin Wewetzer
Keyword(s):  
Differential Expression ◽  
Schwann Cells ◽  
Olfactory Ensheathing Cells ◽  
Ensheathing Cells

scholarly journals Redundant mechanisms of calcium-induced calcium release underlying calcium waves during fertilization of sea urchin eggs

Science ◽  
1993 ◽  
Vol 261 (5119) ◽  
pp. 348-352 ◽  
Author(s):  
A Galione ◽  
A McDougall ◽  
W. Busa ◽  
N Willmott ◽  
I Gillot ◽  
...  
Keyword(s):  
Sea Urchin ◽  
Calcium Release ◽  
Calcium Waves ◽  
Sea Urchin Eggs ◽  
Calcium Induced Calcium Release

scholarly journals IMPROVING SYSTEM READINESS, STAFF PREPAREDNESS AND PATIENT SAFETY IN A NEW SINGLE FAMILY ROOM NICU THROUGH IN SITU SIMULATION

2018 ◽  
Vol 23 (suppl_1) ◽  
pp. e16-e16
Author(s):  
Ahmed Moussa ◽  
Audrey Larone-Juneau ◽  
Laura Fazilleau ◽  
Marie-Eve Rochon ◽  
Justine Giroux ◽  
...  
Keyword(s):  
Patient Safety ◽  
Repeated Measures ◽  
Large Scale ◽  
Multidisciplinary Teams ◽  
Single Family ◽  
In Situ Simulation ◽  
Ensure Patient Safety ◽  
System Readiness ◽  
Dependent Samples

Abstract BACKGROUND Transitions to new healthcare environments can negatively impact patient care and threaten patient safety. Immersive in situ simulation conducted in newly constructed single family room (SFR) Neonatal Intensive Care Units (NICUs) prior to occupancy, has been shown to be effective in testing new environments and identifying latent safety threats (LSTs). These simulations overlay human factors to identify LSTs as new and existing process and systems are implemented in the new environment OBJECTIVES We aimed to demonstrate that large-scale, immersive, in situ simulation prior to the transition to a new SFR NICU improves: 1) systems readiness, 2) staff preparedness, 3) patient safety, 4) staff comfort with simulation, and 5) staff attitude towards culture change. DESIGN/METHODS Multidisciplinary teams of neonatal healthcare providers (HCP) and parents of former NICU patients participated in large-scale, immersive in-situ simulations conducted in the new NICU prior to occupancy. One eighth of the NICU was outfitted with equipment and mannequins and staff performed in their native roles. Multidisciplinary debriefings, which included parents, were conducted immediately after simulations to identify LSTs. Through an iterative process issues were resolved and additional simulations conducted. Debriefings were documented and debriefing transcripts transcribed and LSTs classified using qualitative methods. To assess systems readiness and staff preparedness for transition into the new NICU, HCPs completed surveys prior to transition, post-simulation and post-transition. Systems readiness and staff preparedness were rated on a 5-point Likert scale. Average survey responses were analyzed using dependent samples t-tests and repeated measures ANOVAs. RESULTS One hundred eight HCPs and 24 parents participated in six half-day simulation sessions. A total of 75 LSTs were identified and were categorized into eight themes: 1) work organization, 2) orientation and parent wayfinding, 3) communication devices/systems, 4) nursing and resuscitation equipment, 5) ergonomics, 6) parent comfort; 7) work processes, and 8) interdepartmental interactions. Prior to the transition to the new NICU, 76% of the LSTs were resolved. Survey response rate was 31%, 16%, 7% for baseline, post-simulation and post-move surveys, respectively. System readiness at baseline was 1.3/5,. Post-simulation systems readiness was 3.5/5 (p = 0.0001) and post-transition was 3.9/5 (p = 0.02). Staff preparedness at baseline was 1.4/5. Staff preparedness post-simulation was 3.3/5 (p = 0.006) and post-transition was 3.9/5 (p = 0.03). CONCLUSION Large-scale, immersive in situ simulation is a feasible and effective methodology for identifying LSTs, improving systems readiness and staff preparedness in a new SFR NICU prior to occupancy. However, to optimize patient safety, identified LSTs must be mitigated prior to occupancy. Coordinating large-scale simulations is worth the time and cost investment necessary to optimize systems and ensure patient safety prior to transition to a new SFR NICU.

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