Synthesis, characterization, DNA binding ability, nuclease efficacy and biological evaluation studies of Co(II), Ni(II) and Cu(II) complexes with benzothiazole Schiff base

2018 ◽  
Vol 17-18 ◽  
pp. 159-168 ◽  
Author(s):  
Sreenu Daravath ◽  
Narendrula Vamsikrishna ◽  
Nirmala Ganji ◽  
Kadtala Venkateswarlu ◽  
Shivaraj
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Evaluation Studies ◽  
Biological Evaluation ◽  
Binding Ability

Effect of structure variations on the quadruplex DNA binding ability of nickel Schiff base complexes

2018 ◽  
Vol 47 (38) ◽  
pp. 13573-13591 ◽  
Author(s):  
Kimberley J. Davis ◽  
Nawal M. O. Assadawi ◽  
Son Q. T. Pham ◽  
Monica L. Birrento ◽  
Christopher Richardson ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Nickel Complexes ◽  
Schiff Base Complexes ◽  
Binding Ability ◽  
Quadruplex Dna ◽  
Dna Structures ◽  
Effect Of Structure

The synthesis of two new series of nickel complexes is described, along with their ability to bind to duplex and quadruplex DNA structures.

scholarly journals Copper(ii) complexes based on quinoline-derived Schiff-base ligands: synthesis, characterization, HSA/DNA binding ability, and anticancer activity

MedChemComm ◽  
2018 ◽  
Vol 9 (10) ◽  
pp. 1663-1672 ◽  
Author(s):  
Kun Hu ◽  
Chensi Liu ◽  
Jingui Li ◽  
Fupei Liang
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Tumor Cell ◽  
Anticancer Activity ◽  
Hela Cells ◽  
Cell Apoptosis ◽  
Schiff Base Ligands ◽  
Binding Ability ◽  
Tumor Cell Apoptosis ◽  
Cell Cycles

Three Cu(ii) complexes (C1–C3) were designed and synthesized.C3, in particular, having a ligand derived from benzocaine, exhibited greater selectivity toward HeLa cells, arrested cell cycles, and promoted tumor cell apoptosis.

scholarly journals In Vitro Antioxidant evaluation and DNA binding ability of Ni(II), Co(II), Cu(II) and Zn(II) metal complexes containing bidentate Schiff base

2017 ◽  
Vol 10 (3) ◽  
pp. 06-14
Author(s):  
Mohammad Ibrahim ◽  
Asif Khan ◽  
Bushra Faiz ◽  
Muhammad Ikram ◽  
HazratUn Nabi ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Metal Complexes ◽  
Binding Ability ◽  
Antioxidant Evaluation

Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(ii) complexes

2015 ◽  
Vol 44 (46) ◽  
pp. 19983-19996 ◽  
Author(s):  
Anup Paul ◽  
Sellamuthu Anbu ◽  
Gunjan Sharma ◽  
Maxim L. Kuznetsov ◽  
Biplob Koch ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Biological Evaluation ◽  
Dna Lesion ◽  
Cellular Dna

The synthesis, characterization and biological evaluation of a series of new benzimidazole-based Schiff base copper(ii) complexes.

scholarly journals Chemical Characterization and Biological Evaluation of New Cobalt(II) Complexes with Bioactive Ligands, 2-Picolinehydroxamic Acid and Reduced Schiff Base N-(2-Hydroxybenzyl)alanine, in Terms of DNA Binding and Antimicrobial Activity

2021 ◽  
Vol 14 (12) ◽  
pp. 1254
Author(s):  
Magdalena Woźniczka ◽  
Marta Lichawska ◽  
Manas Sutradhar ◽  
Magdalena Chmiela ◽  
Weronika Gonciarz ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Dna Binding ◽  
Metal Ion ◽  
Binary Systems ◽  
Biological Evaluation ◽  
Cell Nuclei ◽  
Gram Negative ◽  
Heteroligand Complexes ◽  
Reduced Schiff Base

Five new heteroligand cobalt(II) complexes with 2-picolinehydroxamic acid and reduced Schiff base, N-(2-hydroxybenzyl)alanine, were formed in an aqueous solution over a wide pH range. The coordination properties of ligands towards the metal ion were determined using a pH-metric method, and then the speciation model was confirmed by UV–Vis studies. A stacking interaction between the Schiff base phenol ring and the 2-picolinehydroxamic acid pyridine ring was found to improve the stability of the heteroligand species, indicating more effective coordination in mixed-ligand complexes than in their respective binary systems. The antimicrobial properties of heteroligand complexes were determined against Gram-negative and Gram-positive bacteria, as well as fungal strains. The formulation demonstrated the highest bacteriostatic and bactericidal activity (3.65 mM) against two strains of Gram-negative Helicobacter pylori bacteria and towards Candida albicans and Candida glabrata; this is important due to the potential co-existence of these microorganisms in the gastric milieu and their role in the development of gastritis. The binary complexes in the cobalt(II)—2-picolinehydroxamic acid system and 2-picolinehydroxamic acid were not cytotoxic against L929 mouse fibroblasts, neither freshly prepared solutions or after two weeks’ storage. By comparison, the heteroligand complexes within the range 0.91–3.65 mM diminished the metabolic activity of L929 cells, which was correlated with increased damage to cell nuclei. The concentration of the heteroligand species increased over time; therefore, the complexes stored for two weeks exhibited stronger anticellular toxicity than the freshly prepared samples. The complexes formed in an aqueous solution under physiological pH effectively bound to calf thymus DNA in an intercalative manner. This DNA-binding ability may underpin the antimicrobial/antifungal activity of the heteroligand complexes and their ability to downregulate the growth of eukaryotic cells.

Effect of ligand substitution on DNA binding ability of two new square planar copper(II)–Schiff base complexes

2010 ◽  
Vol 975 (1-3) ◽  
pp. 265-273 ◽  
Author(s):  
Dipali Sadhukhan ◽  
Aurkie Ray ◽  
Saurabh Das ◽  
Corrado Rizzoli ◽  
Georgina M. Rosair ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Ligand Substitution ◽  
Schiff Base Complexes ◽  
Binding Ability ◽  
Square Planar
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