Synthesis, DNA binding, cellular DNA lesion and cytotoxicity of a series of new benzimidazole-based Schiff base copper(ii) complexes

2015 ◽  
Vol 44 (46) ◽  
pp. 19983-19996 ◽  
Author(s):  
Anup Paul ◽  
Sellamuthu Anbu ◽  
Gunjan Sharma ◽  
Maxim L. Kuznetsov ◽  
Biplob Koch ◽  
...  
Keyword(s):  
Schiff Base ◽  
Dna Binding ◽  
Biological Evaluation ◽  
Dna Lesion ◽  
Cellular Dna

The synthesis, characterization and biological evaluation of a series of new benzimidazole-based Schiff base copper(ii) complexes.

scholarly journals Chemical Characterization and Biological Evaluation of New Cobalt(II) Complexes with Bioactive Ligands, 2-Picolinehydroxamic Acid and Reduced Schiff Base N-(2-Hydroxybenzyl)alanine, in Terms of DNA Binding and Antimicrobial Activity

2021 ◽  
Vol 14 (12) ◽  
pp. 1254
Author(s):  
Magdalena Woźniczka ◽  
Marta Lichawska ◽  
Manas Sutradhar ◽  
Magdalena Chmiela ◽  
Weronika Gonciarz ◽  
...  
Keyword(s):  
Aqueous Solution ◽  
Schiff Base ◽  
Dna Binding ◽  
Metal Ion ◽  
Binary Systems ◽  
Biological Evaluation ◽  
Cell Nuclei ◽  
Gram Negative ◽  
Heteroligand Complexes ◽  
Reduced Schiff Base

Five new heteroligand cobalt(II) complexes with 2-picolinehydroxamic acid and reduced Schiff base, N-(2-hydroxybenzyl)alanine, were formed in an aqueous solution over a wide pH range. The coordination properties of ligands towards the metal ion were determined using a pH-metric method, and then the speciation model was confirmed by UV–Vis studies. A stacking interaction between the Schiff base phenol ring and the 2-picolinehydroxamic acid pyridine ring was found to improve the stability of the heteroligand species, indicating more effective coordination in mixed-ligand complexes than in their respective binary systems. The antimicrobial properties of heteroligand complexes were determined against Gram-negative and Gram-positive bacteria, as well as fungal strains. The formulation demonstrated the highest bacteriostatic and bactericidal activity (3.65 mM) against two strains of Gram-negative Helicobacter pylori bacteria and towards Candida albicans and Candida glabrata; this is important due to the potential co-existence of these microorganisms in the gastric milieu and their role in the development of gastritis. The binary complexes in the cobalt(II)—2-picolinehydroxamic acid system and 2-picolinehydroxamic acid were not cytotoxic against L929 mouse fibroblasts, neither freshly prepared solutions or after two weeks’ storage. By comparison, the heteroligand complexes within the range 0.91–3.65 mM diminished the metabolic activity of L929 cells, which was correlated with increased damage to cell nuclei. The concentration of the heteroligand species increased over time; therefore, the complexes stored for two weeks exhibited stronger anticellular toxicity than the freshly prepared samples. The complexes formed in an aqueous solution under physiological pH effectively bound to calf thymus DNA in an intercalative manner. This DNA-binding ability may underpin the antimicrobial/antifungal activity of the heteroligand complexes and their ability to downregulate the growth of eukaryotic cells.

Synthesis, Characterization and in vitro Biological Evaluation of a New Schiff Base Derived from Drug and its Complexes with Transition Metal Ions

2018 ◽  
Vol 69 (7) ◽  
pp. 1678-1681
Author(s):  
Amina Mumtaz ◽  
Tariq Mahmud ◽  
M. R. J. Elsegood ◽  
G. W. Weaver
Keyword(s):  
Schiff Base ◽  
Transition Metal ◽  
Metal Ions ◽  
Metal Complexes ◽  
Transition Metal Complexes ◽  
Free Ligand ◽  
Transition Metal Ions ◽  
Biological Evaluation ◽  
Pyridoxal Hydrochloride

New series of copper (II), cobalt (II), zinc (II), nickel (II), manganese (II), iron (II) complexes of a novel Schiff base were prepared by the condensation of sulphadizine and pyridoxal hydrochloride. The ligand and metal complexes were characterized by utilizing different instrumental procedures like microanalysis, thermogravimetric examination and spectroscopy. The integrated ligand and transition metal complexes were screened against various bacteria and fungus. The studies demonstrated the enhanced activity of metal complexes against reported microbes when compared with free ligand.

Synthesis, biological evaluation and DNA binding properties of novel bleomycin analogues

2003 ◽  
Vol 13 (15) ◽  
pp. 2595-2599 ◽  
Author(s):  
Zhi-Dong Xu ◽  
Min Wang ◽  
Su-Long Xiao ◽  
Chun-Li Liu ◽  
Ming Yang
Keyword(s):  
Dna Binding ◽  
Biological Evaluation ◽  
Binding Properties ◽  
Dna Binding Properties
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