Recent developments in organometallic chemistry: 2012

2012 ◽  
Vol 256 (5-8) ◽  
pp. 467
Author(s):  
R. Bruce King
Keyword(s):  
Organometallic Chemistry ◽  
Recent Developments

scholarly journals Organometallic chemical biology: an organometallic approach to bioconjugation

2017 ◽  
Vol 89 (11) ◽  
pp. 1619-1640 ◽  
Author(s):  
Ekaterina V. Vinogradova
Keyword(s):  
Organometallic Chemistry ◽  
Chemical Biology ◽  
Structure And Function ◽  
Future Prospects ◽  
Site Specific ◽  
Organometallic Reagents ◽  
Bond Forming ◽  
Spatially Resolved ◽  
Recent Developments ◽  
And Function

AbstractThis review summarizes the history and recent developments of the field of organometallic chemical biology with a particular emphasis on the development of novel bioconjugation approaches. Over the years, numerous transformations have emerged for biomolecule modification with the use of organometallic reagents; these include [3+2] cycloadditions, C–C, C–S, C–N, and C–O bond forming processes, as well as metal-mediated deprotection (“decaging”) reactions. These conceptually new additions to the chemical biology toolkit highlight the potential of organometallic chemistry to make a significant impact in the field of chemical biology by providing further opportunities for the development of chemoselective, site-specific and spatially resolved methods for biomolecule structure and function manipulation. Examples of these transformations, as well as existing challenges and future prospects of this rapidly developing field are highlighted in this review.

Medicinal organometallic chemistry – an emerging strategy for the treatment of neglected tropical diseases

MedChemComm ◽  
2015 ◽  
Vol 6 (7) ◽  
pp. 1230-1243 ◽  
Author(s):  
Ronald W. Brown ◽  
Christopher J. T. Hyland
Keyword(s):  
Organometallic Chemistry ◽  
Neglected Tropical Diseases ◽  
Tropical Diseases ◽  
Drug Compounds ◽  
Recent Developments

This review summarises recent developments in the search for novel organometallic drug compounds for the treatment of neglected tropical diseases.

RECENT DEVELOPMENTS IN THE ORGANOMETALLIC CHEMISTRY OF TECHNETIUM. PREPARATION AND PROPERTIES OF A POLYNUCLEAR TETRACARBONYL

1963 ◽  
Vol 41 (5) ◽  
pp. 1250-1254 ◽  
Author(s):  
H. D. Kaesz ◽  
D. K. Huggins
Keyword(s):  
Organometallic Chemistry ◽  
Sodium Amalgam ◽  
Recent Developments

A polynuclear tetracarbonyl of technetium, constituting a novel class of carbonyls for the manganese subgroup metals, is formed during the treatment of the pentacarbonyl, Tc2(CO)10, with sodium amalgam and subsequent acidification. The new derivative is characterized, and its possible structure is discussed.

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