Recent developments in the organometallic chemistry of N-heterocyclic carbenes

2007 ◽  
Vol 251 (5-6) ◽  
pp. 595 ◽  
Author(s):  
Robert H. Crabtree
Keyword(s):  
Organometallic Chemistry ◽  
Heterocyclic Carbenes ◽  
Recent Developments

scholarly journals N-Heterocyclic Carbenes: A Door Open to Supramolecular Organometallic Chemistry

2020 ◽  
Vol 53 (7) ◽  
pp. 1401-1413 ◽  
Author(s):  
Susana Ibáñez ◽  
Macarena Poyatos ◽  
Eduardo Peris
Keyword(s):  
Organometallic Chemistry ◽  
Heterocyclic Carbenes

scholarly journals Organometallic chemical biology: an organometallic approach to bioconjugation

2017 ◽  
Vol 89 (11) ◽  
pp. 1619-1640 ◽  
Author(s):  
Ekaterina V. Vinogradova
Keyword(s):  
Organometallic Chemistry ◽  
Chemical Biology ◽  
Structure And Function ◽  
Future Prospects ◽  
Site Specific ◽  
Organometallic Reagents ◽  
Bond Forming ◽  
Spatially Resolved ◽  
Recent Developments ◽  
And Function

AbstractThis review summarizes the history and recent developments of the field of organometallic chemical biology with a particular emphasis on the development of novel bioconjugation approaches. Over the years, numerous transformations have emerged for biomolecule modification with the use of organometallic reagents; these include [3+2] cycloadditions, C–C, C–S, C–N, and C–O bond forming processes, as well as metal-mediated deprotection (“decaging”) reactions. These conceptually new additions to the chemical biology toolkit highlight the potential of organometallic chemistry to make a significant impact in the field of chemical biology by providing further opportunities for the development of chemoselective, site-specific and spatially resolved methods for biomolecule structure and function manipulation. Examples of these transformations, as well as existing challenges and future prospects of this rapidly developing field are highlighted in this review.

N-Heterocyclic Carbene-Organocatalyzed Arene Formation: Application in Atroposelective Synthesis of Polysubstituted Benzenes

Synlett ◽  
2020 ◽  
Vol 31 (10) ◽  
pp. 925-932 ◽  
Author(s):  
Tingshun Zhu ◽  
Ke Xu ◽  
Ziyuan Wang
Keyword(s):  
Organic Chemistry ◽  
Recent Work ◽  
Organic Synthesis ◽  
Heterocyclic Carbenes ◽  
Powerful Method ◽  
Recent Developments ◽  
History Of ◽  
Cyclic Compounds ◽  
Near Future

In recent decades, organocatalysis by N-heterocyclic carbenes (NHCs) has emerged as a versatile and powerful method in organic synthesis. As a result of the power of NHC organocatalysis to produce cyclic compounds, polysubstituted benzenes, which are among the most important cyclic compounds in organic chemistry, can be synthesized efficiently and selectively. This article briefly summarizes the history of NHC organocatalysis, including recent developments in benzene-formation methods, and highlights our recent work in atroposelective arene formation by carbene-catalyzed formal [4+2] cyclo­additions. We expect that more NHC-catalyzed methods for the synthesis of asymmetric arenes will be developed in the near future, providing shortcuts to syntheses of sophisticated chiral functional molecules with polysubstituted benzene nuclei.

ChemInform Abstract: Recent Developments of Metal N-Heterocyclic Carbenes as Anticancer Agents

ChemInform ◽  
2014 ◽  
Vol 45 (35) ◽  
pp. no-no
Author(s):  
Sainath Babaji Aher ◽  
Prashant Narayan Muskawar ◽  
K. Thenmozhi ◽  
Pundlik Rambhau Bhagat
Keyword(s):  
Anticancer Agents ◽  
Heterocyclic Carbenes ◽  
Recent Developments
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