Aberrant crypt foci in patients with a positive family history of sporadic colorectal cancer

2007 ◽  
Vol 248 (2) ◽  
pp. 262-268 ◽  
Author(s):  
Richard G. Stevens ◽  
Helen Swede ◽  
Christopher D. Heinen ◽  
Melissa Jablonski ◽  
Michael Grupka ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Positive Family History ◽  
Aberrant Crypt Foci ◽  
Sporadic Colorectal Cancer ◽  
History Of

scholarly journals Screeners vs. Non-screeners for Colorectal Cancer among People over 50 Years of Age: Factual and Psychological Discriminants

2020 ◽  
Author(s):  
Andrada Ciucă ◽  
Ramona Moldovan ◽  
Sebastian Pintea ◽  
Dan Dumitrașcu ◽  
Adriana Băban
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Positive Family History ◽  
Psychosocial Interventions ◽  
The Elderly ◽  
Roc Curve Analysis ◽  
Convenience Sample ◽  
Colonoscopy Screening ◽  
History Of ◽  
D Values

Background and Aims: Colorectal cancer (CRC) is the third most frequent form of cancer worldwide, and approximately one third of cases have a positive family history of CRC or associated cancers. Colonoscopy is one of the most effective methods of screening for CRC. Uptake of colonoscopy is suboptimal, and many countries lack a national screening programme. Our study aims at exploring and ranking several factual and psychological variables according to their accuracy in discriminating between screeners and non-screeners for CRC in a convenience sample of people over 50 years of age. Methods: The study included 103 individuals aged over 50 years, recruited from day centres for the elderly. We explored socio-demographic variables, frequency of colonoscopy, previous recommendations for screening, health literacy and family history of cancer. Receiver operating characteristic (ROC) analysis was used to establish the discriminative value for each variable between the positive and negative decision for colonoscopy screening. Areas under the curve (AUC) and their equivalent Cohen‘s d values were calculated. Results: Almost a quarter (25.75%) of participants reported previous colonoscopy screening. ROC curve analysis shows that colonoscopy uptake is best discriminated by perceived benefits of screening (AUC=0.71, d=0.78, p<0.001), previous recommendations for screening (AUC=0.68, d=0.69, p<0.001) and previous recommendations for preventive measures (AUC=0.67, d=0.64, p<0.001). Conclusions: Recommendations from healthcare professionals lead to improved colonoscopy uptake when emphasising the benefits of screening. Results can further inform psychosocial interventions by bringing empirical evidence to emphasize screening benefits and explicit recommendations for individuals at risk for CRC cancer.

An alternative approach to identify women at risk for colorectal cancer.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 1513-1513
Author(s):  
Amanda S. Bruegl ◽  
Bojana Djordjevic ◽  
Shannon Neville Westin ◽  
Pamela T. Soliman ◽  
Amanda C. Brandt ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Mismatch Repair ◽  
Dna Mismatch Repair ◽  
Gynecologic Oncology ◽  
Positive Family History ◽  
Dna Mismatch ◽  
Increased Risk ◽  
History Of ◽  
Mlh1 Methylation

1513 Background: Hereditary colorectal cancer (CRC) is preventable; however, identification of individuals at sufficiently high risk to warrant heightened surveillance is difficult. Lynch Syndrome (LS) is an inherited cancer syndrome due to germline mutation in a DNA mismatch repair gene. For women with LS, the lifetime risk of endometrial cancer (EC) is 64% and CRC is 54%. Fifty percent of women with LS will present with EC or ovarian cancer prior to CRC. Therefore, women with LS associated EC represent an ideal group for CRC prevention. The optimal method to identify women with LS associated EC is not known. The purpose of this study was to determine the utility of Amsterdam II and Society of Gynecologic Oncology (SGO) Criteria (modified Bethesda criteria that use EC as the sentinel cancer) in identifying women with LS associated EC. Our ultimate goal is to identify women at increased risk of CRC. Methods: Immunohistochemistry (IHC) for DNA mismatch repair proteins and MLH1 methylation analyses were used to identify LS associated EC among 388 women. EC was designated as LS if there was loss of mismatch repair protein expression. Absence of MLH1 methylation was required to confirm LS in tumors with MLH1 protein loss. Results: Fifty-nine (15.2%) of the EC patients tested had LS. These patients are summarized in the table. Conclusions: Clinical criteria to detect LS identify 17/59 (29%) - 44/59 (74%) of women who present with EC first. EC with MSH2 loss is most likely to occur in younger women and women with positive family history of EC and CRC, features classically associated with LS. In general, the MSH6 mutation is associated with older age at diagnosis and fewer familial CRCs, however, we found a large number of MLH1 (50%) and PMS2 (86%) cases diagnosed at greater than 50 years with no family history of CRC. Our data suggest that classic clinical screening criteria are inadequate to detect patients with LS who present with EC, potentially missing up to 25% of these patients. [Table: see text]

scholarly journals The Correlation between Microsatellite Instability and the Features of Sporadic Colorectal Cancer in the North Part of Iran

2012 ◽  
Vol 2012 ◽  
pp. 1-6 ◽  
Author(s):  
Masoumeh Faghani ◽  
Saba Fakhrieh Asl ◽  
Fariborz Mansour-Ghanaei ◽  
Keyvan Aminian ◽  
Alireza Tarang ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Microsatellite Instability ◽  
Positive Family History ◽  
Tumor Location ◽  
Sporadic Colorectal Cancer ◽  
The North ◽  
Distal Tumor ◽  
North Part ◽  
History Of ◽  
Guilan Province

Background. The aim of this study was to determine the correlation between MSI and sporadic colorectal cancer in Guilan province, North part of Iran.Materials and Methods. A total of 96 patients who underwent resection for sporadic colorectal cancer in Guilan province were studied. No patients had positive family history of cancers. The frequencies of MSI were analyzed by testing the BAT-26 and BAT-25 markers.Results. MSI analysis revealed that 22.9% of the tumors (22 patients) were microsatellite instability positive and 77.1% (74 patients) were microsatellite instability negative. The highest rate of MSI (40.9%) was found in the rectal region. MSI-H status was seen more frequently in distal tumors (P=0.04, odds ratio = 3.13, 0.96–10.14).Conclusions. Distal tumor location and MSI may associate with special clinicopathological features. It seems that there may be correlation with underlying genetic and immunologic mechanisms.

Utilization of colonoscopy and colonoscopic findings among individuals aged 40–54 years with a positive family history of colorectal cancer

2018 ◽  
Vol 27 (6) ◽  
pp. 539-545
Author(s):  
Jasper Plath ◽  
Andrea Siebenhofer ◽  
Ulrike Haug ◽  
Insa Koné ◽  
Marlene Hechtner ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Positive Family History ◽  
History Of

A positive family history of cancer or lifestyle factors may not explain the high incidence of early-onset colorectal cancer in India

2014 ◽  
Vol 3 (5) ◽  
pp. 409-416
Author(s):  
Ratheesh Raman ◽  
Viswakalyan Kotapalli ◽  
Mohana Vamsy ◽  
Sujit C Patnaik ◽  
Mukta Srinivasulu ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Family History ◽  
Early Onset ◽  
Positive Family History ◽  
Lifestyle Factors ◽  
Family History Of Cancer ◽  
High Incidence ◽  
History Of ◽  
Early Onset Colorectal Cancer ◽  
History Of Cancer
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